Chapter 9: The Digestive Sytem Flashcards
Two types of digestion
Intracellular and extracellular digestion
Intracellular digestion
Intracellular digestion is part of metabolism, involves oxidation of glucose and fatty acids for energy.
Extracellular digestion
Extracellular digestion is the process by which nutrients are obtained from food and occurs within the lumen of the alimentary canal. Technically “outside” the body because the lumen interacts and communicates with the outside world.
Alimentary canal
The alimentary canal, aka the digestive tract, is the passageway of the digestive system that runs from the oral canal (mouth) to the anus (aka butthole aka Sean Colebrook)
Sphincters
Circular smooth muscle around the canal that can contract and compartmentalize the alimentary canal.
Digestion
Digestion involves the breakdown of food into its constituent organic molecules: starches and carbohydrates into monosaccharides, lipids (fats) into free fatty acids and glycerol, and proteins into amino acids.
The two kinds of digestion are mechanical and chemical.
Two kinds of digestion
Mechanical and chemical
Mechanical digestion
Mechanical digestion is the physical breakdown of large food particles into smaller particles. Does not involve breaking of chemical bonds.
Chemical digestion
Chemical digestion is the enzymatic cleavage of chemical bonds such as peptide bonds of proteins or glucosidic binds of starches.
Absorption
Absorption involves the transport of products of digestion from the digestive tract into the circulatory system for distribution to the body’s tissues and cells.
Path of the digestive tract
Oral cavity (mouth), pharynx, esophagus, stomach, small intestine, large intestine, rectum, anus (aka Sean Colebrook).
In addition to the digestive tract itself, the salivary glands, pancreas, liver, and gallbladder help to provide the enzymes and lubrication necessary to aid in digestion.
Enteric nervous system
Enteric means of or relating to the intestines. The enteric nervous system is a collection of 100M neurons that govern the gastrointestinal system. This system can function independently of the central nervous system (however is considered part of the autonomic nervous system) but is highly regulated by the autonomic nervous system.
Parasympathetic nervous system stimulated digestion and increases secretion from exocrine glands and promotes peristalsis.
Sympathetic nervous system inhibits digestive activity.
What are all glands of the body innervated by (except the sweat glands)?
All glands of the body (except for the sweat glands) are innervated by the parasympathetic nervous system.
The sweat glands are innervated by the sympathetic nervous system.
Anatomy of the digestive system notes 9.1
Ingestion and Digestion 9.2 Notes
Ingestion and Digestion 9.2 Notes
Six hormones listed in the book involved in feeding behavior
ANTIDIURETIC HORMONE (ADH or vasopressin) secreted by the hypothalamus to the posterior pituitary, and ALDOSTERONE (renin-angiotensin II-aldosterone system, secreted by the adrenal cortex), trigger the sensation of thirst encourage fluid consumption.
GLUCAGON (secreted by the pancreas alpha cells) and GHRELIN (secreted by the stomach and pancreas) stimulate feelings of hunger.
LEPTIN (secreted by adipose tissue) and CHOLECYSTOKININ (secreted by the duodenum) stimulate feelings of satiety.
Three pairs of salivary glands
Parotid gland (just below and in front of ear)
Submandibular gland (below jaw)
Sublingual gland (floor of mouth below the tongue)
Two enzymes found in saliva
Salivary amylase (hydrolyzes starch into smaller sugars like maltose and dextrins)
Lipase (hydrolyzes lipids)
Pharynx
The pharynx leads from the mouth and posterior nasal cavity to the esophagus and larynx.
Three parts of the pharynx
Oropharynx (back of mouth) responsible for initiating swallowing, constitute the upper esophageal sphincter.
Nasopharynx (behind nasal cavity)
Laryngopharynx (above vocal cords)
Epiglottis
The epiglottis is a cartilaginous structure that folds down to cover the laryngal inlet Preventing food from entering the larynx during swallowing.
Esophagus and its muscle composition
The esophagus is a muscular tube that connects the pharynx to the stomach. The connection between the esophagus and the stomach is called the cardiac sphincter.
The top of the esophagus is composed of skeletal muscle, and therefore under somatic control.
The middle is a mix of both smooth and skeletal muscle.
The bottom is composed of smooth muscle, and therefore is completely under autonomic (involuntary) nervous control.
Emesis
Emesis is also known as vomiting. Reversal of peristalsis.
Upper esophageal sphincter
The upper esophagus sphincter is constituted by the muscles of the oropharynx aka the pharyngoesophageal sphincter.
Three main energy sources
Carbohydrates, fats, proteins
The stomach and its four main anatomical divisions
The stomach is a highly muscular organ, located in the upper left quadrant of the abdominal cavity underneath the diaphragm, That uses hydrochloric acid and enzymes to digest food.
The four main anatomical divisions of the stomach are the fundus and body, and the antrum and pylorus.
General anatomy of the stomach image
Rugae of the stomach
Rugae or folds of the lining of the stomach.
Gastric glands, three types, purpose, location
Cardiac glands: beginning of stomach, secrete mucus to protect stomach lining from self digestion. Stomach is highly acidic pH=2.
Intermediate glands: located in the central stomach, these glands produce most of the stomach’s digestive substances (HCl, mucus, pepsin) They contain three types of cells: zymogenic, parietal, and mucous neck cells.
Pyloric glands: located in the terminal portion of the stomach, these glands secrete gastrin.
What are the gastric glands?
The gastric glands respond to signals from the VAGUS NERVE of the parasympathetic nervous system, which is activated by the brain in response to site, taste, and smell of food.
Include:
Cardiac glands: secrete mucus that protect stomach lining.
Intermediate glands (aka true gastric gland): produce most of the stomach’s digestive juices (chief cells- pepsinogen)
Pyloric glands: release gastrin from G cells. Gastrin Gets things Going.
What are the three different cell types of gastric glands?
The three different cell types of gastric glands are mucous cells, chief cells, and parietal cells.
What do the mucous cells of gastric glands do?
The mucous cells of gastric glands produce bicarbonate rich mucous that protects the muscular wall from the harshly acidic (pH=2) and proteolytic environment of the stomach.
What do the parietal cells of gastric glands do (two products)?
The parietal cells of gastric glands secrete hydrogen ions into the stomach as hydrochloric acid which cleaves PEPSINOGEN to PEPSIN. This is a fine example of environmental conditions favoring enzymatic reactions.
The parietal cells also secrete INTRINSIC FACTORS, a glycoprotein involved with proper absorption of vitamin B12.
What do chief cells of gastric glands do?
The chief sells secrete pepsinogen. Pepsinogen is a zymogen form of pepsin, a proteolytic enzyme.
Recall that pepsinogen is activated by low pH into pepsin. This is a fine example of environmental factors influencing enzymatic activity.
The mighty chief pepsinogen. lol
Pepsin and its zymogen, and where does it come from?
Pepsin is a proteolytic enzyme that digest protein by cleaving peptide bonds near aromatic amino acids, resulting in short peptide fragments. Pepsin is activated by the acidic environment of the stomach meaning that it is most active at low pH.
Pepsinogen is zymogen of Pepcid. pepsinogen is released by the chief cells of intermediate gastric glands.
What is the the gastric intrinsic factor?
The gastric intrinsic factor is a glycol protein involved in the proper absorption of B12. The gastric intrinsic factor it’s released by PARIETAL CELLS.
What do the pyloric glands do and contain, and where are they located?
The pyloric glands contain G – cells (in the stomach lining) that secrete gastrin, a peptide hormone. Pyloric glands are located in the pyloric region of the stomach.
Gastrin is a hormone secreted by the pyloric glands that stimulates the secretion of HCl from parietal cells, essentially preparing the stomach for digestion.
What is gastrin, where does it come from, and what does it do?
Gastrin is a peptide hormone secreted by G – cells of the pyloric glands that induces the stomach to secrete more hydrochloric acid and signals the stomach to contract, mixing its contents.