Chapter 9: Muscles Flashcards
Memorize to the best you can xd
Structure of skeletal muscle
- Attach to bone
- under conscious control
- every skeletal muscle is an organ.
skeletal muscles are composed of…
- muscle tissue
- Nervous tissue(excite muscle; electricity)
- Blood-02/nutrients
- connective tissue- structural support
muscle coverings
- Epimysium
- perimysium
- Endomysium
Epimysium
surrounds the whole muscle
fascicle
grouping of muscle fibers
perimysium
surrounds fascicle within a muscle
endomysium
surrounds muscle fibers
Muscle fibers
muscle cell
multinucleated
many cells
sarcolemma
cell membrane
sarcoplasm
cytoplasm
myofibrils
thread like filament
- thin acting filament
- thick myosin filament
sarcomeres
units of muscle
Thick filaments
Myosin protein; heads from cross bridges
thin filaments
Actin protein; associated with troponin and tropomyosin
2 types of bands
I band
A band
I band
light band; actin filaments
A band
Dark band; thick myosin filaments overlapping with thin
acting filaments
Z line
Anchor filaments; center I bands
M line
anchors thick filaments
H zone
center A band; thick myosin filaments
striation pattern
arrangement of myofilaments in myofibrils
contraction of a muscle fiber
*requires interactions from chemical and cellular components
*The actin and myosin filaments slide past one another, shortening the sarcomere
contraction=movement
Neuromuscular junction
axon of a motor neuron, skeletal muscle fibers contract only when stimulated
Parts of the NMJ( neuromuscular junction)
Motor neuron, motor and plate, synaptic cleft, synaptic vesicle, and neuro transmitter
Synaptic cleft
space between nerve and muscle
synaptic vesicle
storage container
neuro transmitter
chemical message
Acetylcholine (ACh)
neuro transmitter
Acetylcholine (ACh) 4 steps to prepare a contraction
1-impulse causes release of ACh from synaptic vesicle
2-ACh binds to ACh receptors
3-causes changes in membrane permeability; Na+, K+(action potential)
4-causes release of Ca2+, leads to muscle contraction
Myasthenia Gravis (MG)
- autoimmune disorder
- antibodies attack ACh receptors
- have only 1/3 normal number of ACh receptors
- Muscle weakness; muscle fatigue
Treatment for MG
- Drugs that inhibit Acetylcholinesterase
* Immunosuppressant drugs
Upon muscle stimulation steps
1- impulses cause SR to release Ca+2 2- Ca+2 ion binds to troponin to change its shape 3- Position of tropomyosin is altered 4- Binding sites on actin; exposed 5- Myosin head forming a cross-bridges
Sliding filament model
- Sarcomeres shorten, thick and thin filaments slide past one another
- Thin and thick, not change length; just overlap
relaxation process
1- acetylcholinesterase; decomposes ACh
2- muscle impulses stop when ACh is decomposed
3- Calcium pump moves Ca+2 back
4- Covers binding sites
5- Troponin-tropomyosin complex covers binding sites
6- Binding is now prevented
7- muscle fiber relaxes