Chapter 8: Genetics of Common Disorders with Complex Inheritance

Question 1

two related individuals in a family with the same disease

Answer 1

concordant

Question 2

when only one family member of a pair of relatives is affected

Answer 2

discordant

Question 3

What is the equation for relative risk ( λr)?

Answer 3

λr = prevalance of the disease in the relatives of an affected person/prevalence of the disease in the general population

Question 4

physiological quantity that can be measured with a mean and a variance

Answer 4

quantitative pehenotype

Question 5

variance of a measured quantity in the population

Answer 5

total phenotypic variance

Question 6

What is the equation for measuring heritability in twin studies?

Answer 6

h2= (variance in DZ pairs - variance in MZ pairs)/variance in DZ paira

Question 7

a plasma protein in the innate immune system that binds to carbohydrates on the surface of many pathogneic organisms and aids in their destruction by phagocytosis and complement activation

Answer 7

MBL2 - mannose binding lectin