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NURS 2514 > CHAPTER 8 DRUGS > Flashcards

CHAPTER 8 DRUGS Flashcards

1
Q

What is the other name for Labetalol?

A

Trandate

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2
Q

What is the classification of Lobetalol (Trandate) ?

A

Betablocker

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3
Q

What is the MOA of Lobetalol (Trandate) ?

A

Blocks stimulation of Beta 1 and Beta 2 adrenergic receptor sites. Also has blocking affect on alpha 1 receptor sites.

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4
Q

Why is Labetalol (Trandate) “antagonist”?

A

Antagonist because it binds to adenergic receptors and blocks stimulation of the sympathetic nervous system

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5
Q

What is the function of Beta 1?

A

Causes increase in HR

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6
Q

what is the function of beta 2?

A

Affects the smooth muscles of bronchioles

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7
Q

What is the indication of Lobetalol (Trandate) ?

A

Management of hypertension

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8
Q

What is the therapeutic effect of Lobetalol (Trandate) ?

A

Decreased blood pressure

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9
Q

why is Labetalol (Trandate) used in emergency situations?

A

Used in emergency situation because it is a potent anti-hypertensive

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10
Q

Labetalol (Trandate) is specific for what?

A

Stroke

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11
Q

where is Labetalol (Trandate) commonly used?

A

Commonly used in acute phase of stroke

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12
Q

Why is Labetalol (Trandate) used for stroke?

A

Blood pressure usually rises following a stroke

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13
Q

Why dose BP go up after a stroke?

A

Thought to be a protective response to maintain cerebral perfusion

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14
Q

When do we administer BP medications in ischemic stroke?

A

If the BP is extremely high

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15
Q

In order to administer thrombolytic therapy for ishemic stroke what must be the BP? Why?

A
  • Systolic BP must be less than 185 mmHg and diastolic must be less than 110 mmHg
  • Due to risk of sheering and bleeding on the arteries.
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16
Q

If patient is not recieving thrombolytics for ishemic stroke, what is the required BP for lobetalol?

A

Only requires if the patients BP is greater than 220 mmHg and diastolic greater than 120 mmHg.

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17
Q

For hemorrhagic Stroke, administer antihypertensive if what BP? why?

A
  • If systolic is greater than 160 mmHg

- Because the higher the pressure the higher the risk for rebleeding

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18
Q

What are the precaution and Containdication of Labetalol (Trandate)? (5)

A
  • Allergies/ hypersensitivity
  • Heart Failure
  • Pulmonary edema and pre-existing obstructive lung disease
  • Bradycardia and heart blocks
  • Use cautiously in renal and liver dysfunction
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19
Q

Why is Pulmonary edema and pre-existing obstructive lung disease contraindications of labetalol?

A

because labetalol blocks Beta 2 which causes a block on relaxation of bronchioles smooth muscles. If labetalol is given then patient will not be able to breath

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20
Q

Why is bradycardia and heart blocks contraindications for labetalol?

A

because we don’t want HR to be more slower –> person can get shock and die

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21
Q

What are the adverse effects of Labetalol (Trandate)? (5)

A
  • Fatigue and weakness
  • Bronchospasm
  • Arrhythmias, bradycardia
  • Congestive heart failure, pulmonary edema
  • Orthostatic hypotension
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22
Q

What is the effects of blocking beta 1

A
  • arrhythmias and bradycardia
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23
Q

What is the effects of blocking beta 2?

A

Bronchospasm

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24
Q

Why is congestive heart failure and pulmonary edema adverse effect of labetalol?

A

Because body is loosing CO due to decrease strength of the heart and lower HR

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25
Q

What are the nursing assessments and considerations for lobetalol (trandate)? (7)

A
  • Administer with meals to increase absorption
  • Frequent monitoring of BP and pulse
  • Take apical pulse prior to administration, if less than 50 bpm, hold medication and notify physician
  • Assess for orthostatic hypotension
  • Monitor intake/output
  • Daily weights
  • Asses for signs of fluid overload (lung crackles, weight gain, edema. fatigue)
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26
Q

You are about to give lobetalol and you checked the patient’s apical pulse and it is less than 50bmp. What should you do?

A
  • Hold the medication and notify physician
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27
Q

How do you asses for orthostatic hypotension?

A
  • take BP lying, sitting, and standing
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28
Q

when giving lobetalol. How do we monitor for heart failure?

A
  • monitor intake/output

- daily weights

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29
Q

what are the signs of fluid overload? (4)

A
  • weight gain
  • Lung crackles
  • edema
  • fatigue
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30
Q

Can students administer intravenous labetalol?

A

No

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31
Q

When receiving intravenous labetalol patients must lay on?

A

supine for 3 hours after administration

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32
Q

Intravenous labetalol is high allert medication therefore nurse must:

A
  • have a second nurse to check the drug independently

- High alert medication –> can be very dangerous

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33
Q

what should nurse do during and after administering intravenous labetalol?

A

Vitals assessed q 5 - 15 minutes during and after administration for several hours

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34
Q

When receiving intravenous Labetalol (3)

A

1) High alert medication - can be very dangerous
2) Patient must lay supine for 3 hours after administration
3) Vitals assessed q 5 -15 mins during and after administration for several hours

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35
Q

What does it mean by high alert medication?

A
  • Monitored
  • Have to get checked by another nurse independently
  • Very dangerous drug
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36
Q

Labetalol (Trandate) patient education (3)

A
  • Abrupt withdrawal of labetalol can cause life threatening arrhythmia’s, hypertension, or myocardial infarction
  • Direct patient to make slow position changes –> special caution when exercising, drinking alcohol, and in hot weather
  • Diabetic patients should have sugar monitored more closely –> medication will mask warning signs of hypoglycemias ( such as tachycardia)
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37
Q

Abrupt withdrawal of labetalol can cause?

A
  • life threatening arrhythmias
  • hypertension
  • myocardial infarction
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38
Q

Why does patient who takes labetalol have to be caution on hot weather?

A

worsens effect

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39
Q

Why do diabetic patient to takes lobetalol have to check their blood sugar more closely?

A

because lobetalol mask the hypoglycemia warning signs such as tachycardia

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40
Q

What is the other name for Acetylsalicylic Acid?

A

Aspirin

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41
Q

What is the classification of Acetylsalicylic Acid (Aspirin)? (2)

A
  • Non- Steroidal Anti-inflammatory Drugs (NSAIDs)

- Cox Inhibitors

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42
Q

What is the indication of Acetylsalicylic Acid (Aspirin)? (4)

A
  • inflammatory disorders
  • Fever
  • Prophylaxis for myocardial infarction and stroke
  • Non opioid analgesic
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43
Q

What is the therapeutic of Acetylsalicylic Acid (Aspirin)? (3)

A
  • decrease pain
  • Decrease inflammation
  • Decreased incidence of stroke and MI
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44
Q

What is cyclooxygenase?

A

an enzyme that converts arachidonic acid into prostaglandins and related compounds ( prostacyclin, thromboxane A2)

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45
Q

Where is cyclooxygenase found?

A

Found in all tissues

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46
Q

cyclooxygenase regulates? (7)

A
  • Tissue injury
  • Stomach
  • Platelets
  • Blood vessels
  • Kidney
  • Brain
  • Uterus
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47
Q

How does cyclooxygenase regulates Tissue injury?

A

Catalyzes the synthesis of prostaglandin, promoting inflammation

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48
Q

How does cyclooxygenase regulates stomach?

A

protects gastric mucosa by reducing gastric acid secretion, increasing bicarbonate and protective mucous, and maintaining submucosal blood flow

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49
Q

How does cyclooxygenase regulates platelets?

A

Promotes synthesis of thromboxane A2 which stimulates platelet aggregation

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50
Q

How does cyclooxygenase regulates blood vessels?

A

Causes vasodilation

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51
Q

How does cyclooxygenase regulates kidneys?

A

Promotes vasodilation, maintains renal blood flow

52
Q

How does cyclooxygenase regulates brain?

A

Prostaglandins that mediate fever and contribute to pain perception

53
Q

How does cyclooxygenase regulates uterus?

A

Prostaglandins promote contractions

54
Q

What are the 2 forms of Cox?

A

Cox 1 and Cox 2

55
Q

What does Cox 1 do? (3)

A
  • Promotes platelet aggregation by synthesizing TXA2
  • Protects gastric mucous by producing gastric mucosa excretion
  • Supports renal flow
56
Q

What does Cox 2 do? (5)

A
  • Mediates inflammatory and synthesize pain receptors
  • Affects brain where it facilitates fever
  • Pain perception
  • dilates blood vessels
  • improve renal flow
57
Q

which one is good and bad? Cox 1 and Cox 2

A

Good - Cox 1

bad - Cox 2

58
Q

What does Aspirin do?

A

Irreversible inhibition of COX 1 and Cox 2

59
Q

What is the purpose of Thromboxane A2?

A

Stimulates activation of new platelets and increases platelet aggregation

60
Q

Stroke often results from?

A

platelet aggregation at site of endothelial damage

61
Q

What does aspirin do to prevent stroke?

A

Aspirin prevents platelet adhesion and aggregation by inhibiting the formation of thromboxane A2 by platelets

62
Q

How long does 1 dose of aspirin last?

A

8 days ( life cycle of platelet)

63
Q

Aspirin is recommended for? (4)

A
  • Ischemic stroke
  • TIA
  • Unstable and Stable Angina
  • Acute MI
64
Q

How much is the recommended amount of aspirin for prevention of cardiovascular disease?

A

81 mg of aspirin per day

65
Q

If person is at risk for GI bleeding and have a risk of cardiovascular disease should they still take aspirin?

A

If higher risk for CVD then aspirin is given, If GI bleed is higher risk then Aspirin is not given

66
Q

When should you give aspirin for ischemic stroke?

A

Initiate within 48 hours of stroke onset ( helps further clotting prevention)

67
Q

Precautions and Contraindications of aspirin (3)

A
  • Allergies/ hypersensitivity/Asthma
  • Bleeding disorders or thrombocytopenia
  • Use cautiously in renal dysfunction, chronic alcohol abuse, history of GI bleeds or ulcer disease, liver disease
68
Q

Large dose of Aspirin can cause what

A
  • Hypoglycemias and enhance the effect if some oral diabetic medications
69
Q

Combining steroids with NSAIDs can cause

A

high risk of ulcer formation

70
Q

Adverse effects of Aspirin (6)

A
  • Heartburn and Nausea
  • GI bleeds
  • Gastric ulceration, perforation, bleeding, haemorrhage
  • Bleeding
  • Renal impairment
  • Salicylism
71
Q

What do to do avoid heart burn and nausea while taking aspirin?

A

Take with food or full glass of water

72
Q

Adverse effect of aspirin GI bleeding may cause

A
  • anemia with chronic occult blood loss
73
Q

What is salicylism?

A

Syndrome resulting from high levels of aspirin

74
Q

what to take to avoid Gastic ulceration, perforation, bleeding, Hemorrhage while taking aspirin?

A

Prophylaxis with a proton pump inhibitor and histamine 2 receptors is recommended

75
Q

adverse effect of aspirin is bleeding, what do you do before surgeries?

A

Discontinue 1-2 weeks prior to surgical procedures

76
Q

How does renal impairment develop while taking aspirin?

A

Causes sodium and water retention = renal failure

77
Q

Aspirin can cause renal impairment. what do you do if renal failure happens?

A
  • acute, reversible impairment in renal function

- Discontinue if renal failure signs starts happening ( weight gain, increase CR and urea

78
Q

signs of salicylism

4

A
  • tinnitus
  • sweating
  • dizziness
  • headache
79
Q

what do to when you see signs of salicylism in patients?

A

With hold aspirin

80
Q

what do we have to do after aspirin is given to patient? (head)

A

Keep head elevated 15 - 30 minutes after drug is given

81
Q

GI effects such as ulcers and GI bleeding results from?

A

increase secretions of acid and decrease production of protective mucus and bicarb and lower submucosal blood flow.

82
Q

Conditions that causes risk for serious ulcers while taking aspirin?(4)

A

1) Advance age
2) History of peptic ulcer
3) Smoking
4) Alcohol - intensifies effect of aspirin

83
Q

What are the risk factors for renal failure while taking aspirin? (3)

A
  • Advance age
  • Pre existing renal issue
  • Hypovolemia ( low fluid volume)
84
Q

What are the signs of aspirin renal failure? (3)

A

1) Weight gain
2) increase CR
3) increase Urea

85
Q

What are the nursing considerations and assessments (5) Aspirin

A
  • Monitor for signs and symptoms of bleeding
  • After procedures and injections apply pressure to the site to prevent bleeding and monitor the site carefully
  • Take aspirin with food or glass of water
  • Discontinue at-least one week prior to surgery
  • Monitor renal function –> weight patient, urea and creatinine levels, urine output
86
Q

what are the signs and symptoms of bleeding (11)

A
  • hypotension
  • tachycardia
  • dizziness
  • weakness
  • pallor
  • bruising
  • bleeding gums
  • epistaxis
  • hematuria
  • melena
  • labs (CBC)
87
Q

What is the other name for Tissue plasminogen Activator?

A

Alteplace

88
Q

what is the classification of TPA

A

Thrombolytic

89
Q

what is the MOA of TPA

A
  • Binds to fibrin in a blood clot and activates plasminogen forming plasmin (fibrinolytic enzyme) which breaks down and dissolves the clot
  • Natural in our body that dissolves clots
90
Q

what is the Indication of TPA (4)

A
  • acute MI
  • Ischemic Stroke
  • Pulmonary embolus
  • Also used to prevent clots in central lines to dissolve clotting
91
Q

what is the Therapeutic effect of TPA

A
  • Breaks down clot and restore blood flow through the vessels
92
Q

What is the route of TPA?

A

Intravenous

93
Q

What is the half life of TPA

A

Short half life - 5 mins

94
Q

TPA is only used for what kind of stroke? what do to use to confirm it?

A
  • Ischemic stroke

- Must be confirmed with CT scan

95
Q

When to administer TPA

A

Must be administered within 4.5 hours of symptom onset

96
Q

Why is TPA administered for stroke?

A

Administered to re establish blood flow through a blocked artery

97
Q

What is the risk for TPA?

A

Increases risk of intracranial hemorrhage because it will clot bust everything

98
Q

what are ABSULUTE contraindications for TPA? Never give TPA To.. (4)

A
  • Previous intracranial bleeding
  • Known intracranial lesions/ tumours
  • Active internal bleeding ( with exception of menses)
  • Suspected aortic dissection ( massive bleeding)
99
Q

Relative contraindications for TPA?

Risky but can maybe give.. (6)

A
  • Severe uncontrolled hypertension > 180/110 mmHg
  • Current anticoagulant use
  • Traumatic/ Prolonged CPR/Surgery <3 weeks ago
  • Recent internal bleeding ( within 2 - 4 weeks )
  • Pregnancy
  • Active peptic ulcer
100
Q

Adverse effects of TPA

A

Bleeding

101
Q

There are two main reasons for bleeding

A

1) Plasmin destroys preexisting clots and can promote bleeding at sites that have recently healed
2) Degradation of clotting factors which disrupts the ability for the body to coagulate when trauma or injury does occur

102
Q

what are the most common sites of bleeding (3)

A
  • recent wounds
  • Sites of needle puncture
  • Site of invasive procedures/surgery
103
Q

Nursing considerations and assessments for TPA (8)

A
  • Patients are screened carefully before administration - ischemic stroke must be confirmed on CT scan
  • Must be administered 3 -4.5 hours of symptoms onset - “door needle” <60 minutes
  • Patient history taken to determine contraindications
  • Frequent monitoring of vital signs and EKG monitoring
  • Glasgow Coma Scale and neurochecks - high risk for intracranial bleeding
  • Monitor for bleeding - Major Risk
  • Hold all anticoagulants and antiplatelets for 24 hours
  • To reduce risk of bleeding –> avoid subcut and IM injections, minimize invasive procedures, do not administer with anticoagulants, do not administer with antiplatelets, minimize how much patient is moving.
104
Q

To reduce risk of bleeding (5)

A
  • avoid subcut and IM injections
  • minimize invasive procedures
  • do not administer with anticoagulants
  • do not administer with antiplatelets
  • minimize how much patient is moving.
105
Q

what kind of heparin is used in stroke

A

unfractionated

106
Q

What is the classification of Heparin?

A

Anticoagulant

107
Q

What is the MOA of Heparin?

A
  • Enhance activity of antithrombin which is a protein that inactivates clotting factors ( thrombin and factor Xa). Without these two clotting factors, there is reduced production of fibrin and clotting is suppressed.
  • No effect on clots that is already made. Just prevents clot formations
108
Q

What is the indication of Heparin? (5)

A
  • Pulmonary embolism
  • Deep vein thrombosis
  • Dialysis and open-heart surgery
  • Post-operative, spinal cord injury, stroke DVT prophylaxis –> to be initiated within 48 - 72 hours of ischemic stroke
  • Acute myocardial infarction
109
Q

What is the therapeutic effect of Heparin?

A

Prevention of new clots

110
Q

Why do we give heparin after operations?

A

We give heparin so that clots are prevented on the foreign objects

111
Q

Adverse effects of heparin (3) how and who they develop

A
  • Bleeding/ hemorrhage –> develops in about 10% of patients
  • Epidural hematoma –> can develop in patients with epidural/spinal anaesthesia
  • Heparin induced thrombicytopenia (HIT) –> immune mediated disorder causing reduced platelet counts and increase in thrombotic events. Antibodies develop against heparin - platelet complexes
112
Q

What to do to prevent Epidural hematoma

A
  • Stop heparin several hours before taking out the epidural to reduce bleeding
113
Q

What happens During HIT?

A
  • Sudden clotting in small arteries

- Platelets become hyperactive and forms mini clots which affects microvascular

114
Q

What organs are affected with HIT?

A

Hands, fingers, feet, kidneys (microvascular)

115
Q

Signs of positive HIT

A
  • blueish fingers, toes, etc
  • lost circulation to their feet and kidneys
  • platelets count drops by 50%
116
Q

What is the antidote of heparin

A

Protamine Sulfate - positive ion binds to negative ions of heparin. Neutralizes heparin which last for 2 hours.

118
Q

Nursing Considerations and assesment for heparin (5)

A
  • Monitor vital signs
  • Labs –> Monitor aPTT ( activated partial thromboplastin time), should be checked every 4-6 hours when on heparin infusion, monitor platelets and Hgb
  • Monitor for signs and symptoms of bleeding –> melina, pallor, bleeding, gums, epistaxis, hematuria
  • Monitor hands and feet for colour, warmth, circulation, movement –> signs of clot from heparin induced thrombocytopenia.
  • Monitor for HIT –> CWCS
119
Q

Atorvastatin other name

A

Lipitor

119
Q

Atorvastatin Therapeutic effect

A
  • Lower LDL cholesterol
  • Elevated HDL cholesterol
  • Reduce Triglycerides
120
Q

Atorvastatin classifications

A
  • HMG-CoA reductase inhibitor

- “Statins”

121
Q

Atorvastatin MOA

A
  • Lowers the rate of cholesterol production
  • HMG-CoA reductase synthesizes –> statins block the enzyme which decreases cholesterol production
  • liver increases LDL receptors and hepatocytes remove LDL from blood
122
Q

Atorvastatin indication (3)

A
  • Hypercholesterolemia
  • Risk reduction for stroke, myocardial infarction, and angina
  • Diabetes
123
Q

Additional facts of atorvastatin (3)

A
  • well tolerated overall, minimal s/e
  • TETRANOGENIC
  • should not have grapefruit juice
124
Q

Atorvastatin nursing considerations (3)

A
  • check serum lipid levels and triglycerides
  • Should assess liver function (LFTs)
  • Administer in evening ( works best at night because cholesterol synthesis works at night)
125
Q

how long do you have to take Atorvastatin ?

A

Lifetime medication

126
Q

Doses effect of atorvastatin

A

small- 25% decrease cholesterol

high dose - 60% decrease on cholesterol

127
Q

What are the signs of aspirin renal failure? (3)

A

1) Weight gain
2) increase CR
3) increase Urea

NURS 2514 (11 decks)

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