Chapter 8 CTD Flashcards
Lesion of DLE, diff localized from disseminated
Dull red macules or indurated plaques developing adherent scale evolve with atrophy scarring pigment changes
Loc - above neck, scalp bridge of nose malar lower lip ears (concha ext canal)
- perifollicular erythema, easily extractable anagen hair -> sign of active dse, response to tx
Disseminated - less common than prev, thorax ue head neck, more common elev esr ana ssdna leukopenia
Histo of sle
Compact hyperkeratosis without parakeratosis, follicular plugging, hydropic degen of basal epidermis and follicular epith, patchy perivascular and adnexal lymphoid infiltrate in dermis, inc mucin
Lesion of LE LP overlap syndrome
Large attophic hypopigmented red or pink patches and plaques with fine telangiectasia and scaling on extensors and midline back and palmoplantar
What is chillblain LE
Or hutchinson
Chronic unremittng LE on fingertips rims of ears calves heels in women
Usually preceded by DLE on face
What is tumid LE lesion
Edematous eryth plaques usually on trunk
Responds to antimalarials
Lesions of LE panniculitis
SubQ nodules that are firm sharply defined nontender
Usually in women ages 20-45
- lipodermatosclerosis resembling frost on windowpane - stasis panniculitis
Lesion of scle
Histo
Scaly, evolve as polycyclic annular or psoriasiform plaques, red to pink, scales easily detached, telangiectasia or dyspigmentation, follicles not involved, transient or migratory lesions, no scarring
Vacuolar interface dermatitis, mild hyperkeratosus and parakeratosis, NO fol plugging bmz thickening heavy lymphoid, variable dermal mucin
Drug induced scle rel to which drug
HCTZ
Others: acei ccb interferon anticonvulsant griseofulvin glyburide piroxicam penicillamine spironolactone terbinafine statins
Neonat LE born to moms with which antibody
Ro/SSA antiB
No skin lesion at birth, dev first wks of life
Annular eryth macules, plaques on head ext, periocular (raccoon)
Heal spontaneously by 6mos
Mc third deg heart block
Complement def usually found in scle
C2 C4
