Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Dermatology ANDREWS > Chapter 1 Skin > Flashcards

Chapter 1 Skin Flashcards

You may prefer our related Brainscape-certified flashcards:
Dermatology Board Prep flashcards
1
Q

From where does apocrine sweat units and sebaceous gland originate?

A

Apocrine frim upper follicular epithelium

Sebaceous from midregion of follicle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the pattern of merkel cell when with poly and monoclonal keratin 20 staining?

A

Paranuclear dot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Mutation in keratin 5,14 and 1,10 result to?

A

Epidermolysis bullosa simplex
Epidermolysis keratosis
Respectively

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What regulates epidermal differentiation?

A

Histones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

3 manifestations of abnormal keratinization?

A 
Parakeratosis (retained nuclei) 
Corps ronds (rounds, clear to pink abN keratinized cells)
Grains (elongated, basophilic, abN keratinized)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the phases of keratinization?

A

Synthetic

Degradative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are responsible for desmosomal adhesion?

A

Cadherins

Desmogleins and desmocollins (Calcium dep)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Responsible for keratin filament aggregation

A

Filaggrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Melanocyte:keratinocyte ratio?

A

1:10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Appearance of melanocyte in H&E stain?

A

Cell with ample amphophilic cytoplasm or as a clear cell in the basal layer of epidermis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Where are melanosomes produced?

A

Golgi bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Reason for red head?

A

LOF mutation in melanocortin 1 receptor (MC1R) –> eumelanin to pheomelanin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Reason for vitiligo and albinism?

A

Vitiligo - destruction of melanocyte

Albinism - N # of melanocyte, unable to fully pigmented melanosomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Layer of epidermis where langerhan cells are found?

A

Spinosum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Stain for langerhans? How do they appear?

A

Gold chloride, CD1 alpha, S-100

Dendritic cells in sections, with folded nucleus and distinct intracytomplasmic organelles and birbeck granules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Where does langerhans originate

A

Bone marrow

Monocyte-macrophage lineage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Function of langerhans

A

In the afferent limb of immune response by providing for recog, uptake,processing and presentation of antigens to sensitized T lympho; impt in induction of delayed type hypersensitivity

18
Q

Components of dermoepidermal junction

A

Plasma membranes of basal cells with hemidesmosomes; lamina lucida; lamina densa (basal lamina); fibrous comp (anchoring fibrils, dermal microfibrils, collagen)

19
Q

2 major hemidesmosomal proteins

A

BP230 bullous pemphi antigen 1

BP180 bullous pemphi ant 2, type XVII collagen

20
Q

Origin of eccrine apocrine glands ducts and pilosebaceous units

A

Ectodermal

21
Q

What is acrosyringium

A

Intraepidermal spiral duct opens directly onto skin surface

22
Q

Excretion of sweat is mediated by what innervation

A

Cholinergic (biphasic)

23
Q

Decapitation secretion can be found in?

A

Apocrine glands

24
Q

Apocrine secretion mediated by?

A

Adrenergic and circulating catecholamines

25
Q

Sites of apocrine glands

A

Axillae areola anogenital EAC(ceruminous glands) eyelids (glands of moll) stroma of sebaceous nevus of Jadasshon

26
Q

Phases of haur growth

A

Anagen, active, 3-5y, 85-90%, 0.37mm/day
Catagen, involution, 2wks
Telogen, resting, 3-5mos

27
Q

What is telogen effluvium

A

Result of early release from anagen induced by fever surgery weight loss

28
Q

Hair shape partially controlled by what gene

A

Trichohyalin gene

29
Q

Growth of nail

A

0.1mm/day, 4-6mos to complete a nail plate

12-18m for toe nail

30
Q

Infant vs adult dermis

A

Infant - small collagen bundles staib deep red, many fibroblast
Adult - few fibroblast, thick collagen bundles stain pale red

31
Q

2 dermal dendritic cells in adult dermis

A

Factor XIIIa positive

CD34+

32
Q

Major structural protein for the body

A

Collagen

33
Q

Downregulation of which collagen mrna in photoaging

A

Coll I and III mrna

34
Q

Type of collagen in BMZ

A

IV

35
Q

Type of collagen in anchoring fibrils

A

VII

36
Q

2 components of elastic fibers

A

Protein filaments

Elastin

37
Q

Ground substance of dermis components

A

Sulfated acid mucopolysaccharide (chondroitin, dermatan sulfste), neutral mps, electrolytes

38
Q

Minor component of dermis, accumulates in pathologic states

A

Hyaluronan

39
Q

Vasculature in between papillary and reticular dermis

A

Subpapillary plexus (postcapillary venules)

40
Q

Vasculature at dermal-subcutaneous interface

A

Lower horizontal plexus

Dermatology ANDREWS (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions