Chapter 8 Flashcards
What are the two main purposes of the kidneys?
- filter nitrogenous products of metabolism from the blood
2. maintain water and electrolyte homeostasis
The kidney produces two hormones that have nothing to do with its excretory function. What are they ?
- erythropoietin: stimulates bone marrow to produce RBD
- active form of Vit D that the kidney makes from the inactive form consumed in the diet or formed by the skin on exposure to sunlight.
What are the two distinct zones in a kidney?
- outer layer called the cortex
2. an inner layer called medulla.
The cortex is composed of 1 milion nephrons. Filtration takes place in the nephron of the kidney, which has two parts…what are they?
- the flomerulus
2. the tubule
The walls of golerular capillaries are composed of 3 layers of cells. Define them
- endothelial layer: allows passage of proteins through openings called fenestrae
- the basement membrane: traps the lager proteins molecules and does not allow them into the filtrate
- Epithelial layer: compose of modified epithelial cells called podocytes. They have a number of radiating foot-like processes and slit diaphragms that form narrow channels that futher restrict the molecules that pass into the filtrate.
What do you call the capsule that surrounds a glomerulus? And the space within the capsule surrounding the glomerulus?
Bowman’s capsule
Bowmans space
Where does the two-step filtration process of waste products take place in the kidney?
It is in the nephrons of the kidney
Define the two-step filtration process.
- capillaries of the glomeruli filter 120-180 liters of fluid per day. This glomerular filtrate, flow’s into Bowman’s capsule that surrounds the glomerular tuft.
- The filtrate flows into the tubule where the other step of filtation occurs- which involves reabsorption of the filtrate .
This concentrated fluid remains in the urine.
What action forces urine downward from the kidney through the ureter to the bladder? What stops urine from flowing back-upwards
Peristaltic contractions.
Sphincter muscles at the ureterovesical junction
What hormones are used to control the amount of salt and water that are reabsorbed by the kidneys during the filtration process?
- ADH- produced by the pituitary when the blood concentration of sodium rises. IT acts on the kidney to retain water until the concentration of sodium falls to normal. It is controlled by the hypothalamus
- Aldosterone causes the kidney to retain sodium, its produced from the adrenal gland and is controlled by the hypothalamus.
- Renin- produced by the kidneys, triggers the formation of angiotensin in the bloodstream when the blood volume or blood pressure falls. This controls salt levels and HTN. This is activated when the kidneys are not getting enough blood.
What is the most common evidence of renal disease in terms of abN production of kidneys?
There is an excess amount of protein being products: ie: Proteinuria in a 24hr collection.
What are two common benign causes for proteinuria
- exercise, fever, stress, excessive cold, vaginal contamination
- orthostatis proteinuria- condition in which individual has proteinuria when upright and does not occur when pt is in supine.
Define microalbuminuria
Small amount of albumin in the urine,
Define hematuria and the difference bertween gross and microscopic
RBC or frank blood in the urine
gross indicates the blood can be seen with the naked eye
micro indicates that the RBC can be seen with microscope
What are the 5 most common causes of hematuria?
- stones
- nephritis
- tummors - bening/malignant
- prostate disease
- benign familial hematuria
- menstruation can cause isolated hematuria.
What is Pyuria and what causes it?
the presence of WBC (pus) in the urine.
caused by infection or inflammation ie: cystitis, urethritis, or prostatitis
when do you see casts?
they are formed when a protein produced by nephrons gels around whatever is in its vicinity.
can be RBC, WBC, or granular casts or fatty casts.
What is a hyaline cast?
empty casts,- just the gelled protein.
Name the most common cause for the following cast presence:
- RBC cast
- WBC cast
- Epithelial casts
- granular casts
- fatty casts
- waxy casts
- glomerulonephritis
- inflammatory conditions, glomerulonephritits, pyelonephrotos, interstitial cystitis
- nephritic syndrome, tubular injury, glomerulonephritis
- glomerulonephritis
- nephritic syndrome
- advanced renal failure
Define the term Dysuria
discomfort on urination, used to refer specifically a burning sensation felt in the urethra on urination.
usually a sxs of urethritis and/or cystitis
What is meant by the term retention?
bladder being incompletely emptied at each voiding.
Caused by prostate enlargement, neurlogical disease, DM, cystocele, and some Rx.
Define Azotemia, and its cause
Refers to an elevation of blood urea nitrogen (BUN) and creatinine levels.
- intrarenal causes
- pre-renal causes d/t failure of blood to reach kidney for filtration
- post renal cause - d/t obstruction to urinary flow after it leaves the kidney
What is Uremia?
the condition resulting from the advances stages of kidney failure.
sxs secondary to renal damage: anemia, weight loss, weakness, nausea and vomiting, excessive bleeding, edema, convulsions, coma.
What is Oliguria and its causes?
decreased urine output. <500ml in 24 hr.
- dehydration
- total urinary tract obstruction
- severe infection leading to shock
- medications
What is Anuria?
Clinically less than 100ml of urine in 24 hrs.
caused by drop in BP, d/t shock or hemorrhage or possibly obstruction.
What is renal colic?
Sharp pain in back/groin caused by spasm of the ureter as a stone is being forced from the kidney to the bladder.
How does one characterize nephrotic syndrome?
Heavy proteinuria accompanied by edema, hyperlipidemia, hypercoagulability, and hypoalbuminermia.
> > The glomeruli are damaged and therefore cause them to be more permeable to protein molecules
What testing can be done through a blood test to determine Renal problems/
- BUN- depends on the kidneys efficiency and amount of protein consumed.
- Creatinine- measures kidney function,
- creatinine clearance- volume of plasma cleared of creatinine per min. (usually requires 24 hour collection)
- Cystatin C - sensitive early marker for chronic kidney disease
What is creatinine
Waste product of muscle metabolism
What is cystatin C
a protein that inhibits the action of substances that break down proteins in the body. It is filtered in the glomeruli. then reabsorbed. If the kidneys are not functioning these levels are increased.
What is KUB?
An xray of the abdo (Kidney, ureter, bladder).
May show stones
What is a cystoscopy?
allows for a direct look inside the bladder and urethra, it is also used to inspect the prostate.
used to delinate many bladder conditions such as infection, hematuria, adbomal cells in urine samples or painful urination
What is IVP and what is it used for?
IVP= intravenous pyelogram
procedure where iodine-containing substance is injected and an Xray is used to watch it pass through the kidneys.
- the speed in which the substance is excreted allows meaure of kidney funciton and comparison
What is a Retrograde Pyelogran
A small catheter is placed in a ureter, dye is injected through the catheter and xrays taken.
- used when pt is allergic to IV contact in IVP.
What are Renal scans?
similar to IVP but substance that kidney is excreting is labeled with radioactive isotope and scan is done with gamma camera. ‘
used to show blood flow and organ function.
What is ultrasonography of the kidneys
painless, noninvasive procedure that uses sound waves to delineate structures in the urinary system.
detect: hydronephrosis, kidney stones, diffuse renal disease and other abN.
]differentiates between solid cystic lesions.
What is CT scanning used to detect
?
dx kidney and uretral stones, pyelonephritis, urinary obstruction and malignancy
What is MRI used to detect>
staging renal cancers, evaluating renal masses seen on CT or u/s and evaluate renal vascular disease.
What is renal angiography and why is it used?
speclialized xray of blood vessels of the kidneys. Contrast medium, introduced into the blood stream by catheter, to show renal arteries to be better seen on X-ray.
used for tumors, blood clots, stenoses, aneurysms of the renal artery.
What would you use the following tests for?
- flow studies
- urethral pressure recordings
- cystometry
- measure actual flow of urine
- dx outflow obstruction
- delineate total bladder capacity, ability to contract, initiation/ihibitation of voiding and the presence or absence of residual urine.
Infections of the lower urinary tract in females are usually in what form?
Cystitis or urethritis.
sxs are: frequency, dysuria, and sometimes hematuria.
tx’ed: abx
What are the typical causes of lower urinary infections in men?
urethritis or prostatitis
Urethritis: caused by specific infections or non-specific. >usually both contracted by sexual exposure
Prostatitis is caused by intestinal bacteria either acute: sxs similar to custitis or chronic.
tx’ed with abx
What is interstitial Cystitis?
syndrome of urinary frequency and severe irritative voiding sxs with no indication of infection-
dx: cystoscopy reveals inflammed and ulcerated bladder wall. biopsies required to rule out carcinoma insity.
affects: middle age females associated with incontinentce.
- tx’ed: Rx, or procedures (DMSO, bladder dilation, etc). varies in success. Can remove bladder as last resort.