Chapter 8 Flashcards
What factors should be considered in the determination of chemo doses?
Body surface area, body weight
After what tests can chemo doses be adjusted?
Neutrophil count, renal and hepatic function, history of previous adverse events
Under what conditions con a chemo prescription be repeated?
On instruction of a specialist
What chemo drugs are most commonly associated with oral mucositis?
Fluorouracil, anthracyclines, methotrexate
What measures can be taken to prevent oral mucositis?
Good oral hygiene
With fluorouracil, sucking ice chips may help
What can be used to treat oral mucositis?
Saline mouthwash
What cancer types are most likely to cause tumour lysis?
Non - Hodgkin’s lymphoma
Burkitt’s lymphoma
Acute lymphoblastic leukaemia
Acute myeloid leukaemia
Occasionally solid tumours
What may predispose a patient to tumour lysis syndrome?
Hyperuricaemia
Dehydration
Renal impairment
What are the symptoms/signs of tumour lysis syndrome?
Hyperuricaemia
Hyperkalaemia
Hyperphosphataemia
Hypocalcaemia
Renal damage
Arrhythmias
What cancers have the highest risk of hypeuricaemia?
High grade lymphoma and leukaemia
What main clinical finding is associated with hypeuricaema?
Acute renal failure
What drug should be used and when should it be used to combat hyperuricaemia?
Allopurinol - 24 hours prior
Febuxustat - 48 hours prior
Which chemo requires dose reduction when coprescribed with allopurinol?
Mercaptopurine
Azathioprine
What drug can be used specifically for hyperuricaema associated with haemetological malignancy?
Rasburicase
What chemo does not cause bone marrow suppression?
Vincristine
Neomycin
