Chapter 7 - metabolism Flashcards
metabolism
the sum of all chemical and physical processes by which the body breaks down and builds up molecules
calorimeter
measures a food’s caloric content
anabolism
the process of making larger, chemically complex molecules from smaller ones; critical for growth, repair, and the synthesis of chemical products essential for human functioning
catabolism
the breakdown of larger, complex molecules to smaller, more basic ones; begins with digestion and includes old cells and tissues that are broken down for repair or replacement
metabolic pathways
clusters of chemical reactions that occur sequentially to achieve a particular goal, occur in a specific part of a cell, and may be limited to specific organs or tissues
dehydration synthesis
an anabolic process in which water is released as a byproduct
hydrolysis
a usually catabolic process where a large molecule is broken down with the addition of water
phosphorylation
the addition of a phosphate group to a compound
oxidation
one half of an exchange reaction where a molecule donates an electron to an oxygen atom
reduction
one half of an exchange reaction where oxygen gains an electron and becomes more negatively charged
enzymes
substances that mediate chemical reactions
coenzymes
non-protein substances that enhance or are necessary for enzyme activity, such as FAD, FADH2, and vitamins
cofactors
typically minerals required for enzyme activity, such as iron, magnesium, zinc
glycolysis
an anaerobic reaction occurring in the cytosol
lipolysis
dietary and adipose triglycerides are broken down by lipase to yield glycerol and three free fatty acids
ketones
byproducts of fat catabolism
ketosis
occurs when ketones inappropriately lower blood pH
ketoacidosis
occurs when blood pH falls, further resulting in severe dehydration
proteolysis
dietary proteins are digested into amino acids or small peptides
starvation
the body turns to its own tissues for energy
alcohol oxidation
occurs primarily in the liver at a constant rate of about one drink per hour; gluconeogenesis by alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and microsomal ethanol oxidizing system (MEOS)
first-pass metabolism
small amount of alcohol is oxidized in the stomach, before being absorbed into the bloodstream
gluconeogenesis
making new glucose from nonglucose substrates, primarily glucogenic amino acids; maintains blood glucose during sleep, fasting, trauma, and exercise
protein catabolism
can start to draw on vital tissue proteins such as skeletal and heart muscles and organ proteins for glucose production
lipogenesis (de novo synthesis)
making fats from nonfat substances such as carbohydrates, amino acids, and alcohol; mostly occurs in liver cells as acetyl CoA units form fatty acid chains which combine with glycerol to form triglycerides when excess calories are consumed
insulin
the primary anabolic hormone; increases in the blood after a meal, activates storage enzymes, and signals cellular uptake of glucose, fatty acids, and amino acids
catabolic hormones
glucagon, epinephrine, and cortisol; trigger the breakdown of stored triglycerides, glycogen, and body protein for energy
anabolic state
bloodstream is enriched with glucose, fatty acids, and amino acids