Chapter 7 (Exam 2) Flashcards

1
Q

what are the two primary emotions in mood disorders?

A
  1. DEPRESSION- a low, blue, sad emotional state in which this feeling is overwhelming
  2. MANIA- a state of frenzied energy (sometimes with a sense of euphoria or grandiosity); NOT the same as happiness- mania may include anger or irritability
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2
Q

how common is unipolar depression/major depressive disorder?

A
  • prevalence rate: 7-8%
    lifetime prevalence rate:
    women: 26%, men: 12%
  • 20% of all adults experience unipolar depression at some time in their lives
  • more than half of indiv who have a major depressive episode will experience another at some point (recurrence and relapse are concerns)
  • 85% will recover but most will have another episode (half do not seek treatment and it gets better)
  • rate of depression is higher in people with lower economic means
  • women are twice as likely to be diagnosed with depression
  • avg age of onset: 19 y/o
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3
Q

symptoms
unipolar depression/major depressive disorder

A

five main areas of functioning:
1. emotional symptoms (feeling miserable, empty, or humiliated; experiencing little pleasure)
2. motivational symptoms (lacking drive, initiative, spontaneity; 6-15% of those with severe depression commit suicide )
3. behavioral symptoms (less active/productive; socially withdrawn; staying in bed for long periods of time)
4. cognitive symptoms (negative self-views; blame themselves for unfortunate events; pessimistic; distracted/poor concentration)
5. physical symptoms (headaches, dizzy spells, GI symptoms, general pain, sleep disturbances, appetite changes, fatigue)

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4
Q

diagnostic criteria
depression

A

TWO MAJOR DIAGNOSES TO CONSIDER:
1. major depressive disorder/unipolar depression (crit 1 and 2 met)
2. persistent depressive disorder
- symptoms are mild but chronic
- depression is longer lasting but less disabling
- depressed mood plus 2+ other symptoms
- consistent symptoms for AT LEAST 2 years (one for children and adolescents)
- symptoms never disappear for more than two months

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5
Q

double depression

A

when persistent depressive disorder leads to major depressive disorder

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6
Q

what causes unipolar depression/major depressive disorder?

A

STRESS/STRESSFUL NEGATIVE EVENT may trigger depression
- people with depression experience a greater number of stressful life events during the month before onset of symptoms
- some clinicians distinguish reactive (exogenous) depression from endogenous depression

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7
Q

exogenous depression

A

outside of the person; related to stressful life events

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8
Q

endogenous depression

A

arise from internal factors, usually biological (neurochemical composition, etc.)

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9
Q

biological view: causes of
depression

A

genetic factors
- 30% of people with depressed relatives are depressed (compared with fewer than 10% of the population)
- heritability: 40%
- 2/3 of chromosomes carry genes related to depression
twin concordance rates:
- identical: 38%
- fraternal: 20%

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10
Q

biochemical factors: neurotransmitters
depression

A

neurotransmitters: SEROTONIN and NOREPINEPHRINE
- truly effective antidepressants release depression by increasing either serotonin or norepinephrine
- there are other NTs involved (e.g. glutamate)
- depression circuit

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11
Q

in the 1950s, medications for _______ were found to cause depression

A

HIGH BLOOD PRESSURE MEDS
- some lowered serotonin, others lowered norepinephrine

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12
Q

biochemical factors: hormones
depression

A

ENDOCRINE SYSTEM/HORMONE RELEASE
- people with depression have abnormally high levels of cortisol
- overly reactive HPA axis (in response to stress)
- depression circuit

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13
Q

depression brain circuit

A
  • structural problems; interconnectivity (lowered connection between neurons)
  • irregular activity and flow rate in various brain locations

GLUTAMATE
PREFRONTAL CORTEX (higher or lower levels of activity)
HIPPOCAMPUS (undersized, production of new neurons is low)
AMYGDALA (overactive; high blood flow)
SUBGENUAL CINGULATE (smaller than it should be yet overly active)

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14
Q

immune system theory
depression

A

people with depression have:
- LOWER levels of LYMPHOCYTES
- HIGHER levels of C-REACTIVE PROTEIN
- HIGHER levels of INFLAMMATION

do these cause depression or is depression a severe stressor that leads to immune system problems?

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15
Q

biological TREATMENTS
depression

A

ANTIDEPRESSANTS
- monoamine oxidase inhibitors (MAOs)
- tricyclics
- second generation antidepressants (SSRIs)
- ketamine-based drugs
BRAIN STIMULATION
- electroconvulsive therapy and other forms of brain stimulation

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16
Q

MAO inhibitors
depression treatment

A
  • discovered in 1950s by accident
  • Iproniazid helped improve depression
  • works because they INHIBIT MAOs (which break down serotonin and norepinephrine)
  • MUST be on a strict diet (can not eat anything with Tyramine because their blood pressure would sky rocket to dangerous levels)
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17
Q

tricyclics
depression treatment

A
  • discovered by accident
  • Imipramine was developed for schizophrenia
  • serotonin and norepinephrine reuptake inhibitor
  • unfavorable side effects
  • success rate: 50-60%
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18
Q

second-generation antidepressants
depression treatment

A

SSRIs (selective serotonin reuptake inhibitors)
SNRIs (selective norepinephrine reuptake inhibitors)
SSNRIs (serotonin norepinephrine reuptake inhibitors)
- hard to overdose on these
- common side effects: weight gain and lowered sex drive
- downside: they take weeks to take effect

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19
Q

ketamine-based drugs
depression treatment

A
  • increases GLUTAMATE activity (may aid in new neural pathway development); helps with neuroplasticity and can promote interconnectivity/synaptic connections
  • 70% of people with treatment-resistant depression respond to ketamine
  • ONLY done in a medically supervised setting
  • ONLY used for treatment resistant/severe depression (pt must have tried at least 2 antidepressants before consideration
  • typically given through IV
  • does NOT have long lasting effects (wears off after 2 weeks; need booster sessions)
  • side effects: dizziness, confusion, memory problems, high bp, dissociative symptoms, HIGH RISK OF ADDICTION
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20
Q

electroconvulsive therapy (ECT)
depression treatment

A
  • targeted electrical stimulation, causes a brain seizure (pt is unconscious and given muscle relaxants)
  • course of treatment: 6-12 sessions over 2-4 weeks
  • ONLY used for treatment-resistant and severe depression
  • effective and fast-acting
  • memory loss/issues are potential side effects
  • quicker response to treatment than drug or psychotherapy
  • treatment may be bilateral or unilateral
  • success rate: 50-80% improvement
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21
Q

other brain stimulation
depression treatment

A
  • vagus nerve stimulation (VNS)- implanted pulse generator sends electrical signals to the vagus nerve, and then to the brain
  • transcranial magnetic stimulation- stimulates the prefrontal cortex with electromagnetic currents daily for 4-6 weeks (as effective as ECT)
  • deep brain stimulation- electrodes implanted deep within brain and low voltage is sent to Brodmann Area 25, which is theorized to be a “depression switch”; invasive procedure
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22
Q

theoretical explanation: cog behavioral
THEORETICAL PERSPECTIVES
depression

A

depression results from problematic behaviors and dysfunctional thinking

theoretical perspectives:
- behavioral dimension
- negative thinking

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23
Q

theoretical explanation: cog behavioral
LEWINSOHN
depression

A
  • result of changes in rewards and punishments people receive in their lives (Lewinsohn suggests that the pos rewards in life dwindle for some, leading them to perform fewer and fewer constructive behaviors and they spiral towards depression)

research supports the relationship between the number of rewards received and the presence/absence of depression (social rewards are especially important

24
Q

theoretical explanation: cog behavioral
BECK
depression

A

Beck theorizes four interrelated cog components combine to produce depression:
1. MALADAPTIVE ATTITUDES- developed in childhood; self-defeating: “if I fail, others will hate me”
2. COGNITIVE TRIAD- experiences and the future are interpreted negatively
3. ERRORS IN THINKING- minimizing the pos and magnifying the neg
4. NEG AUTOMATIC THOUGHTS- a constant, neg stream of thoughts involving inadequacy and hopelessness

***supported by research

25
behavioral treatment depression
GOLD STANDARD: Beck's CBT (4 phases): 1. increasing activities and elevating moods 2. challenging automatic thoughts 3. identifying neg thinking and biases 4. changing primary attitudes evaluation: 50-60% success rate; limited help as a solo treatment; more helpful in combination with cog techniques (behavioral therapy alone can help mild depression) new therapies: acceptance and commitment therapy (ACT)- recognition and acceptance of neg cognitions evaluation: effective with unipolar depression and with follow-up preventive cog therapy
26
relationship between persistent depressive disorder and ______
BPD the symptoms overlap; many people with BPD have persistent depressive disorder
27
theoretical explanation: sociocultural depression
unipolar depression is influenced by the social context that surrounds people (this belief is triggered by the finding that depression is often triggered by outside stressors) there are 2 kinds of sociocultural views: 1. family-social perspective 2. multicultural perspective
28
theoretical explanation: family-social perspective depression
the connection between declining social rewards and depression (as discussed by behaviorists) is a two-way street - depressed people often display social deficits that make others uncomfortable, which may cause them to avoid the depressed indiv - this leads to decreased social contact and a further deterioration of social skills
29
treatment: family-social perspective depression
interpersonal therapy (IPT)- this model holds that 4 interpersonal problems may lead to depression and must be addressed: 1. interpersonal loss (e.g. death/break up) 2. interpersonal role dispute (within relationship) 3. interpersonal role transition (life changes) 4. interpersonal deficits (e.g. social awkwardness( IPT is AS effective as CBT (50-60% improve)
30
theoretical explanation: multicultural perspective depression
a strong link exists between GENDER and DEPRESSION - women are twice as likely to be diagnosed with unipolar depression - women appear to be younger (when diagnosed), have more frequent, and longer-lasting bouts, and respond less successfully to treatment
31
multicultural perspective THEORIES depression
theories that explain the gender differences in rates of depression: - ARTIFACT THEORY- women and men are equally prone to depression, but clinicians fail to detect it in men - HORMONE EXPLANATION- hormone changes trigger depression in women - LIFE STRESS THEORY- women experience more stress than men - BODY DISSATISFACTION THEORY- females are under more pressure to be thin - RUMINATION THEORY- women ruminate about their depressed mood more than men - LACK OF CONTROL THEORY- women feel less in control of their lives than men
32
comparing treatments for unipolar depression
cog behavioral (CBT), interpersonal (IPT), and biological therapies - all highly effective treatments for mild to severe depression - relapse is less likely if drug and psychotherapy are done together - a combination of therapies is more helpful than either treatment alone; drug therapy shows a faster response but CBPT and IPT show equal improvement rates to drug therapy after 12 weeks
33
bipolar disorders
people with bipolar disorder experience both the lows of depression and the highs of mania - many describe their lives as an emotional roller coaster - extreme shifts between moods - have a dramatic impact on relatives and friends
34
symptoms of mania
people in a state of mania typically experience dramatic and inappropriate rises in mood (often ego syntonic) five main areas of functioning may be affected: 1. EMOTIONAL symptoms- active, powerful emotions in search of an outlet 2. MOTIVATIONAL symptoms- need for constant excitement, involvement, companionship 3. BEHAVIORAL symptoms- very active; move quickly, talk loudly or rapidly; they feel there isn't enough time to do everything they want to do; flamboyance is not uncommon 4. COGNITIVE symptoms- show poor judgment or planning, refusing to listen to others who may try to slow them down or prevent them from making poor judgments; may have trouble remaining coherent or in touch with reality 5. PHYSICAL symptoms- high energy level, often in the presence of little or no rest
35
egosyntonic
feels good
36
egodystonic
feels bad
37
manic episode (dx checklist)
for 1 week or more, person displays a continually elevated, expansive, or irritable mood as well as continually heightened energy or activity (for most of every day) person also experiences AT LEAST 3 symptoms (4 if the mood is only irritable): - grandiosity or overblown self-esteem - decreased NEED for sleep - more talkative than usual or the pressure to keep talking - rapidly shifting ideas or the sense that one's thoughts are racing - distractibility/attention pulled in many directions - heightened goal directed activity (socially, at work or school, sexually) or agitated movements - excessive pursuit of risky and potentially problematic activities **significant distress or impairment
38
Bipolar I Disorder (diagnosis checklist)
adult prevalence rate: 1.5% avg age of onset: 22 y/o
39
Bipolar II Disorder (diagnosis checklist)
adult prevalence rate: 0.8% avg age of onset: mid-20s
40
general info bipolar disorders
- indiv. tend to experience more depression over mania over the years (more frequent and longer lasting episodes of depression) - lifetime suicide risk: 20-30x increased risk of suicide - equally common in men and women (women more experience more depressive episodes and fewer manic episodes more than men; rapid cycling is more common in women) - more common among people with low incomes
41
cyclothymic disorder
15-50% of people with this are diagnosed with bipolar I or bipolar II onset- diagnosed at younger age (first symptoms can appear in childhood) than bipolar (early adulthood)
42
theoretical explanation: biological NEUROTRANSMITTERS bipolar disorders
- low norepinephrine and low serotonin (can explain depression) - early researchers expected to find a link between high norepinephrine levels and mania (supported by some research studies) - bipolar disorders may be related to overactivity of norepinephrine and low serotonin activity - more studies show dopamine and glutamate may also be involved
43
theoretical explanation: biological ION bipolar disorders
- ions (which are needed to send incoming messages to nerve endings) may be improperly transported through the cells of individuals with bipolar disorder - some theorists believe that irregularities in the transport of these ions may cause neurons to fire too easily (mania) or to stubbornly resist firing (depression) *there is some research for this theory
44
theoretical explanation: biological BRAIN STRUCTURE bipolar disorders
abnormal brain structure: BASAL GANGLIA, HIPPOCAMPUS, CEREBELLUM other structural abnormalities: RAPHE NUCLEI, STRIATUM, AMYGDALA, PREFRONTAL CORTEX
45
theoretical explanation: biological GENETICS bipolar disorders
people may inherit a biological predisposition to developing bipolar disorders family pedigree studies support this: - identical twins: 40-70% likelihood - fraternal twins: 5-10% likelihood - general population: 1-2.8% likelihood - 90% heritability rate in some twin studies - molecular biology- genes on 13 chromosomes have been linked to bipolar disorders
46
treatments bipolar disorders
MEDICATION IS THE GOLD STANDARD -lithium - mood stabilizers
47
treatments LITHIUM bipolar disorders
- extraordinarily effective - determining the correct dosage is delicate (too low= no effect; too much= lithium intoxication/poisoning)
48
treatments MOOD STABILIZERS bipolar disorders
mood stabilizers- antiseizure drugs for mania: Lamictal, Depakote, and Tegretol for bipolar depression: atypical antipsychotics (Latuda)- blocks dopamine and serotonin - MORE THAN 60% OF PATIENTS WITH MANIA IMPROVE ON THESE MEDICATIONS - most indiv experience fewer new episodes while on the drug - findings suggest the mood stabilizers are also prophylactic drugs (ones that actually help prevent symptoms from developing) - mood stabilizers also help those with bipolar overcome their depressive episodes to a lesser degree; SOME PT WILL ALSO BE PLACED ON ANTIDEPRESSANT MEDS OR ATYPICAL PSYCHOTIC FOR DEPRESSIVE EPISODES
49
how do mood stabilizing drugs operate? (bipolar disorder)
researchers do NOT fully understand how mood stabilizing drugs operate? - they suspect the drugs change synaptic activity in neurons, but in a different way from that of antidepressant drugs (although antidepressant drugs affect a neuron's initial reception on NTs, mood stabilizers seem to affect a neuron's second messengers - these drugs also increase the production of neuroprotective proteins (BDNF), which may decrease bipolar symptoms - they may improve communication between key structures in the brain (lithium increases the size of the hippocampus and gray matter in patients)
50
treatments ADJUNCTIVE PSYCHOTHERAPY bipolar disorders
psychotherapy alone is RARELY HELPFUL for persons with bipolar disorder (but it CAN be sufficient) - mood stabilizing drugs alone are also not always sufficient (30% or MORE of patients don't respond, may not receive the correct dose, and/or may relapse while taking them) AS A RESULT... clinicians often use psychotherapy as an adjunct to drug therapy - psychotherapy increases medical compliance and reduces hospitalization - psychotherapy is often a central part of treatment for cyclothymic disorder (often more so than medication)
51
how long do hypomanic episodes usually last?
4 days
52
hypomanic vs manic episode
hypomania- milder, less disruptive form of mania mania- more severe and potentially disruptive state characterized by elevated mood, increased energy, and impaired functioning
53
what is rapid cycling in bipolar disorder
4 or more mood episodes (depression or mania) in a given year
54
bipolar children in 1989
kids were being misdiagnosed a LOT; non episodic irritability and moodiness in children, usually manifests as anxiety and depression in adulthood
55
adults with bipolar experience ______ irritability
episodic