Chapter 14 (Exam 2) Flashcards
how have indiv with schizophrenia been treated in the past?
they were considered BEYOND HELP
- the discovery of antipsychotic drugs enabled schizophrenics to think CLEARLY and BENEFIT from PSYCHOTHERAPY
which theoretical model is the most effective for schizophrenia?
biological
what was institutional care like (in the past) for schizophrenics?
for more than half of the 20 century, schizophrenics were institutionalized
- because they failed to respond to traditional therapies, the primary goal was to RESTRAIN them and give them FOOD, SHELTER, and CLOTHING
what 2 approaches brough hope to chronic schizophrenic patients in the 1950s?
- Milieu therapy (humanistic principles)
- token economies (behavioral principles)
these helped improve personal care, self-image of patients (problem areas that were worsened by institutionalization)
Milieu therapy (humanistic principles)
approach for schizophrenia treatment
institutions CAN help patients make progress by creating a SOCIAL CLIMATE (milieu) that promotes productive activity, self-respect, and individual responsibility
- Milieu-style programs set up in the west had moderate success
- research shows that pt with schizophrenia in milieu programs often leave the hospital at higher rates than pt receiving custodial care
token economy (behavioral principles)
approach for schizophrenia treatment
based on operant conditioning principles; patients are REWARDED when they behave in a SOCIALLY ACCEPTABLE way and not rewarded when they behave unacceptably
- immediate rewards are tokens that can be later exchanged for food, cigarettes, privileges, and other desirable objects
- acceptable behaviors likely to be targeted include care for oneself and one’s possessions, going to a work program, speaking normally, following ward rules, and showing self-control
these helped REDUCE PSYCHOTIC BEHAVIORS
the first antipsychotic
schizophrenia
discovered in 1950s, revolutionized treatment
- antihistamines (phenothiazines) were used to calm patients about to undergo surgery
- chlorpromazine was tested on patients with psychosis and sharp symptom reduction observed; it had a calming effect
- in 1954, chlorpromazine (thorazine) was approved by FDA as an antipsychotic
how did first-gen antipsychotics work?
they bind to D2 receptors, thereby blocking dopamine; helped positive symptoms
first-gen antipsychotic drugs
drugs developed from 1960s-1980s are known as FIRST-GEN antipsychotics
- they are also known as NEUROLEPTIC DRUGS (because they often produce undesired movement effects similar to symptoms of neurological diseases)
- most of these work by reducing dopamine activity
how effective are anti-psychotics?
antipsychotic drugs reduce schizophrenia symptoms in at least 70% of pt
- drugs appear to be more most effective than any other approach used alone
in most cases, drugs produce MAXIMUM IMPROVEMENT within the FIRST 6 MONTHS of treatment (symptoms may return if pt stops taking them too soon)
what are unwanted effects of first-gen anti-psychotics?
EXTRAPYRAMIDAL EFFECTS (impacts these areas in the brain):
- parkinsonian and related symptoms
- neuroleptic malignant syndrome
- tardive dyskinesia
parkinsonian and related symptoms
extrapyramidal effects of first-gen antipsychotics
at least 50% develop symptoms including:
- tremors, rigidity, feet shuffling
- involuntary muscle contractions
result of medication-induced reductions of dopamine activity in the striatum
neuroleptic malignant syndrome
extrapyramidal effects of first-gen antipsychotics
POTENTIALLY FATAL (esp in older adults)
symptoms:
- muscle rigidity, fever, autonomic dysfunction
tardive dyskinesia
extrapyramidal effects of first-gen antipsychotics
symptoms are similar to psychotic symptoms; difficult to eliminate
takes 6 months - 1 year to develop symptoms such as:
- involuntary muscle movements (~20% developed this side effect)
success rate of first-gen antipsychotics
65%
success rate of second-gen antipsychotics
85%
success rate/efficacy of antipsychotics (in general)
70%
since learning of the unwanted side effects of first-gen antipsychotics, clinicians must _______
BE MORE CAREFUL IN THEIR PRESCRIPTION PRACTICES
- they try to prescribe the LOWEST effective dose
- gradually reduce or stop medication weeks or months after pt begins functioning normally
second-generation antipsychotic drugs
different biological operation than first-gen:
- received at fewer dopamine D2 receptors; more D1 and D4 and serotonin receptors than others
- symptoms: weight gain, dizziness, significant elevations in blood sugar
- reduce pos AND some neg symptoms
- cause fewer extrapyramidal symptoms and less tardive dyskinesia (although 7% still develop it with second-gen)
- MOST COMMONLY PRESCRIBED medicine for schizophrenia
what is the most frequently prescribed antipsychotic?
CLORAZIL (second-gen antipsychotic)
what is a risk of second-gen antipsychotics?
AGRANULOCYTOSIS- a life-threatening drop in white blood cells
1-1.5% of people develop this, therefore…
- for the first few months, pt needs their blood drawn once/week
first-gen vs second-gen antipsychotic side effects (graph)
CONVENTIONAL- first gen
ATYPICAL- second gen
psychotherapy
schizophrenia
before antipsychotics, psychotherapy was not an option (pt were far too removed from reality)
today, it is helpful in COMBINATION with drug therapy (most helpful: CBT, family therapy, and social therapy)
cog behavioral therapy
COGNITIVE REMEDIATION
schizophrenia
COGNITIVE REMEDIATION- focuses on difficulties in attention, planning, and memory
- provides increasingly more complex computer tasks until planning and social awareness tasks are reached
provides MODERATE IMPROVEMENT:
- improvements in memory, attention, planning, and problem-solving surpass other interventions
- extend to everyday client life and social relationships