Chapter 64 - Guyton Flashcards
Glands of the GI tract.
goblet cells - mucus
pits (crypts of Lieberkühn in small intestine) - secretions
tubular glands - secretion (acid- and pepsinogen-secreting gland of the stomach)
salivary glands, pancreas, and liver - secretions for digestion or emulsification of food
What is the primary stimulus of secretions in the GI tract?
food contact with the epithelium
Parasympathetic stimulation of the gut ________ secretions.
increases
Control of secretions.
local - tactile, distention, irritation
reflex - nervous input
hormonal - GI hormones
Sympathetic stimulation of the gut _________ secretions.
increases or decreases (decreases if parasympathetic is already increasing)
What is secreted along with a substance to move it?
water and electrolytes
Mucus composition.
mainly water, electrolytes, glycoprotein
Mucus properties that make it essential for digestion.
adherent - sticks to food body - coats the walls well low resistance - provides lubrication self adherent - sticks together (form poop) resistant to digestion by GI enzymes buffering - neutralize acids
Salivation glands.
parotid, submandibular, sublingual (also smaller buccal)
Saliva contains two major types of protein secretion:
1) serous secretion that contains ptyalin (an
a-amylase), an enzyme for digesting starches
2) mucus secretion that contains mucin for lubricating and surface protective purposes
Types of secretion by gland.
parotid - serous
submandibular and sublingual - serous and mucus
buccal - mucus
90% of total secreted saliva comes from which glands?
parotid and submandibular
Two stages of formation and secretion of saliva.
acini - primary secretion similar to plasma (Cl is primary ion that is secreted actively not Na)
salivary ducts - modified as it passes through the ducts
Sodium and chloride in saliva is _____ than in plasma, while potassium and bicarbonate is _____ than in plasma.
less; greater
Saliva is always hypotonic, but its osmolarity _________ as its flow rate increases.
increases
Xerostomia
absence of saliva (dry mouth)
____________ stimulation directly increases salivation but can decrease Ach stimulated effects because of blood vessel constriction.
Sympathetic (T1-T3, superior cervical ganglion)
Parasympathetics to the salivary glands through which cranial nerves primarily?
CN IX and X (Ach)
Tubular glands of the stomach mucosa.
The oxyntic (acid-forming) glands secrete hydrochloric acid, pepsinogen, intrinsic factor, and mucus. The pyloric glands secrete mainly mucus for protection of the pyloric mucosa from the stomach acid. They also secrete the hormone gastrin.
What occurs in order for pepsinogen to be converted into its active form pepsin?
contact with HCl and pepsinogen is cleaved into pepsin
In chronic gastritis, if the parietal cells are destroyed, a person can develop achlorhydria (lack of stomach acid secretion) but often also pernicious anemia due to what?
lack of secretion of intrinsic factor by the parietal cells leads to failure to absorb B12
The _______ cells, located deep in the oxyntic glands of the main body of the stomach, are the only cells that secrete hydrochloric acid.
parietal
The rate of formation and secretion of hydrochloric acid by the parietal cells is directly related to the amount of histamine secreted by which cell?
enterochromaffin-like cells (ECL cells)
Stimulates histamine production by ECL cells:
1) gastrin
2) Ach (vagus nerve)
3) hormonal substances secreted by enteric nervous system in the stomach wall