Chapter 32 - Guyton Flashcards
Pluripotent stem cells develop into either?
lymphoid or myeloid stem cell
Lymphoid stem cells develop into either?
T-cell and B-cell
Myeloid stem cells develop into?
eosinophil, basophil, neutrophil, monocyte (macrophage), platelets, erythrocyte
Main function of erythrocytes (RBCs).
transport hemoglobin
Normal hematocrit.
40-45%
Iron is transported in the blood in which form?
ferrous
Hormone released from kidney in response to low renal oxygenation.
erythropoietin (stimulates stem cell formation of pronormoblasts, release of reticulocytes, increase in red cell number in 5 days)
Where is erythropoietin produced?
peritubular interstitial cells of the kidney (always present in the plasma)
Normal Hg levels.
15-16 (male) gm Hg/100 mL blood, 13-14 (female) gm Hg/100 mL blood
Normal oxygen carrying capacity.
~21 ml O2/100 mL blood men, ~19 ml O2/100 mL blood women
If hematocrit is low, the percentage of reticulocytes will be greater/lower.
greater
Primary site of hemopoietic activity in adults.
bone marrow
Hemoglobin excreted as?
bilirubin
Plasma levels indicative of iron deficiency.
ferritin
Sites of functional iron vs. storage iron.
functional - RBCs, muscle, bone marrow
storage - liver, monocytes/macrophages