Chapter 6 - White blood cell disorders

Question 1

What is a normal blood cell count?

Answer 1

5 - 10 K/µL

Question 2

What are the two main causes of Neutropenia?

Answer 2

1. Drug toxicity

2. Severe Infection

3. Aplastic anemia
4. SLE
5. Radiation

Question 3

What are the four main causes of Lymphocytopenia?

Answer 3

1. Immunodeficency (DiGeorge, HIV)

2. High cortisol state (Corticosteroid, chusings)

3. Autoimmune destruction (SLE)

4. Whole body radiation

Question 4

WHat are the two main causes of neutrophilic leukocytosis?

Answer 4

1. Bacterial infection or tissue necrossis

2. High cortisol state

Question 5

What are the two main causes of monocytosis?

Answer 5

1. Chronic inflammatory states

2. Malignancy

Question 6

What are the three main causes of eosinophilia?

Answer 6

1. Allergic reactions

2. Parasitic infection

3. Hodgkin lymphoma

Question 7

Which disorder is clasically associated with basophilia?

Answer 7

Chronic Myeloid Leukemia

Question 8

What are the two main causes of lymphocytic leukocytosis?

Answer 8

1. Viral infection

2. Bordatella pertussis

Question 9

Case: 16 year old male presents with pharyngitis with generalized lymphadenopathy and hepatosplenomegally. You perform a cross reaction test with horse and sheep blood which is positive.

Which pathogen may have caused the sympoms, but have been excluded by the cross reaction test?

Answer 9

Infectious mononucleosis

EBV infection results in lymphocytic leukocytosis, it can also be caused by CMV virus. A postive monospot test (cross reaction test) rules out CMV.

Question 10

Case: HIV patient develops B-cell lymphoma. The past medical history indicates a previous B-cell infection which may have caused it. What else can the dormant B-cell virus in question cause?

Answer 10

EBV

Recurrent Infectious mononucleosis.