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1. NAPLEX Prep > Chapter 6: Drug Formulations adn Patient Counseling > Flashcards

Chapter 6: Drug Formulations adn Patient Counseling Flashcards

1
Q

Olanzapine formulations

A

IR tablet, ODT, short-acting injection, long-acting injection

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2
Q

Ondansetron formulations

A

IR tablet, oral solution, ODT, oral film, short-acting injection

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3
Q

Suffixes for long acting formulations:

A

XL, XR, ER, LA, SR, CR, CRT, SA, TR, cont

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4
Q

Osmotic Release Oral Systems (OROS)

A

Provides fast drug delivery, followed by an extended release.
Water from the gut is absorbed into the delivery system through osmosis, which increases the pressure inside and forces the drug out through a small opening.
The tablet/capsule shell may be visible in the patients stool (ghost tablet/capsule), but the drug has been released

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5
Q

Reasons for long-acting formulations

A

Drugs may be designed to release slowly to avoid nausea or to provide a long-duration of action. Providing a smooth level of drug release over time reduces high “peaks”, which reduces side effects and provides a safe level of drug over the dosing interval

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6
Q

Counseling for long-acting formulations

A

Do not crush or chew any drug that is in a LA formulation. It could release all of the medication at once, and a fatal dose could be released.

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7
Q

Is shaking required for suspensions or solutions?

A

Required for suspensions to redisperse the medication prior to administration.

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8
Q

What type of chewable tablets are popular for adults?

A

Chewable calcium tablets

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9
Q

Lozenges/troches

A

Used to treat a condition in the oral mucosa; the drug is held in the mouth while the troche slowly dissolves

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10
Q

Mycelex

A

Clotrimazole, for oral thrush

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11
Q

What is the most common cause of dysphagia?

A

Paralysis of the throat muscles from stroke

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12
Q

What are reasons for ODT formulations?

A

Dysphagia, children, nausea, vomiting, non-adherence

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13
Q

Patient counseling for granules, powders, or capsules that can be opened or sprinkled

A

Do not chew any long-acting pellets or beads
If capsule contents are mixed into liquid or food, do not let the mixture sit for too long (take within the time directed)
Do not add to anything warm or hot.

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14
Q

Singulair-motelukast granules instructions

A

In 5 mL of baby formula or breast milk or in a spoonful of applesauce, carrots, rice, or ice cream

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15
Q

Vyvanse granules instruction

A

In water, yogurt, or orange juice

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16
Q

Sorbitol metabolism

A

Produces gas, cramping, and bloating in sensitive patients, including those with IBS

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17
Q

Phenylalanine

A

Used in many ODT, chewable, and granule medication formulas. Is a dangerous sweetener for those with phenylketonuria (PKU), a genetic deficiency in which the enzyme that degrades phenylalanine is absent.

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18
Q

Lactose

A

Most common excipient in drug formulations. It many be an issue in patients with lactose intolerance

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19
Q

Subcutaneous injections

A

Patients can self-administer
Examples- naloxone, Imitrex, insulins
SC administration is used for rapid effect or for drugs that would degrade or not be absorbed if given orally.

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20
Q

Long-acting IM injectinos

A

Improve adherence or to decrease the need for more frequent injections.

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21
Q

IV Injections

A

Bypasses the oral route
Fast response, avoids drug loss due to N/V

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22
Q

Glatiramer
Room temp stability
Injection location
Frequency

A

Room temp stability- 30 days
Injection location- Abdomen, arms, hips, thighs
Frequency- daily or three times per week

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23
Q

Etanercept
Room temp stability
Injection location
Frequency

A

Room temp stability-14 days
Injection location- Thigh (preferred), abdomen, upper arm
Frequency- once or twice weekly

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24
Q

Humira (adalimumab)
Room temp stability
Injection location
Frequency

A

Room temp stability- 14 days
Injection location- Abdomen, thigh
Frequency- Every other week

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25
Certolizumab Room temp stability Injection location Frequency
Room temp stability- prefilled syringes up to 7 days Injection location- abdomen, thigh Frequency- every 2-4 weeks
26
Golimumab Room temp stability Injection location Frequency
Room temp stability-up to 30 days Injection location- Thigh, lower abdomen below navel, upper arm Frequency- Monthly
27
Teriparatide (Forteo) Room temp stability Injection location Frequency
Room temp stability- minimize, should be stored in fridge Injection location- thigh, abdomen Frequency- daily
28
Abaloparatide Room temp stability Injection location Frequency
Room temp stability- up to 30 days Injection location- Abdomen Frequency- Daily
29
Enoxaparin Room temp stability Injection location Frequency
Room temp stability- never refrigerated Injection location -abdomen, > 1 inch from navel Frequency- 1-2 times daily
30
Fondaparinux Room temp stability Injection location Frequency
Room temp stability- never refrigerated Injection location- Abdomen, >1inch from navel Frequency- Daily
31
Methotrexate Room temp stability Injection location Frequency
Room temp stability- never refrigerated Injection location- Abdomen, thigh Frequency- weekly
32
Sumatriptan Room temp stability Injection location Frequency
Room temp stability- never refrigerated Injection location- upper arm, thigh Frequency- PRN at first sign of migraine
33
Injectable medication counseling
1.) Wash hands 2.) Prepare injection 3.) Select and clean injection site 4.) Inject 5.) Discard in sharps container
34
Anticoagulation injections
Do not rub the skin around anticoagualtion injections (enoxaparin, fondaparinux); rubbing can cause severe bruising
35
How to heat up cold injectable medications?
Let sit at room temperature for 20 min
36
Safe handling of monoclonal antibodies
Proteins can denature (break apart) if handled incorrectly Do not shake medication Avoid exposing to extreme temperatures Store in fridge prior to use and slowly bring to room temperature prior to injecting
37
Common application sites for patches
Upper chest, lower and upper back, upper arm, flanks
38
Exelon
Applied to chest, back, or upper arm. Not flanks
39
Daytrana
Applied to the hip, alternating right and left hips daily
40
Transderm Scop
Applied behind the ear at least 4 hours before needing, alternating ears every 72 hrs
41
Vivelle-Dot
Apply at lower abdomen or buttock
42
Oxytrol
Apply at abdomen, hip, or buttock
43
Xulane
Apply to back, abdomen, arm, or buttock
44
Which patches are changed daily?
Methyphenidate- QAM 2 hours before school Nicotine Rivastigmine Rotigotine Selegiline Testosterone
45
Which patches are applied twice daily?
Diclofenac
46
Which patches are applied twice weekly?
Estradiol (alora, vivelle-dot) Oxybutynin Can be used 3 weeks on and 1 week off
47
Which patches are applied weekly?
Buprenorphine Clonidine Estradiol (Climara) Estradiol/Levonorgestrel Ethinyl estradiol/Norelgestromin (Xulane)
48
Which patches are applied every 72 hours?
Fentanyl- if it wears off after 48 hrs, can change to Q48H Scopolamine
49
Which patches are applied daily with special instructions?
Lidocaine- 1-3 patches on for 12 hours and off for 12 Nitroglycerin- on for 12-14 hours, off for 10-12 hours
50
Can I cut a patch into pieces?
Usually no, except for Lidoderm, which is designed to be cut and applied over painful regions
51
Can the patch be exposed to heat from an electric blanket, heating pad, or body temp >38 C (100.4F)?
Avoid heat. Heat causes rapid absorption
52
The patch is bothering my skin. What can I do?
Never apply to skin that is irritated Alternate the application site The skin should not be shaved shortly before applying; shaving is irritating to the skin. If needed, cute the short hair with scissors. A topical steroids, such as hydrocortisone, can be applied after the patch is removed.
53
Which patches need to be removed prior to an MIR?
Patches containing metal need to be removed prior to an MRI or the metal will burn the skin. Clonidine, Rotigotine, Scopolamine, Testosterone Patches containing the same medication (generics) may vary in metal content. It is widely recommended that estradiol patches be removed prior to MRI.
54
Can the patch be covered with tape if it will not stick or falls off?
Most patches cannot be covered with tape. Fentanyl and buprenorphine can be covered only with the permitted adhesive film dressings, Bioclusive or Tegaderm Catapres comes with its own adhesive cover Never apply patches to oily skin When applied, patches have to be smoothed out on the skin, and then pressed down for a number of seconds, usually 10-30.
55
How do I dispose of patches?
In most cases, remove and fold the patch to press adhesive surfaces together for disposal. Some highly potent narcotic patches (Duragesic, Butrans, Daytrana) can be fatal if ingested by a child or pet and you should flush them
56
Where is the drug located in a patch?
The drug can be in a raised pouch, reservoir, or directly into the adhesive
57
Nasal spray route
Has a faster onset than the oral route and is useful for acute condigtions. Nasal sprays bypass gut absorption; some proteins that would be absorbed by the gut (calcitonin) can be given nasally.
58
Nasal spray counseling
Shake the bottle gently before use Prime the pump before first use or when you haven't used it recently (7-14 days) Blow your nose to clear the nostrils Close one nostril, insert nasal applicator into the other nostril Breathe in through your nose, press firmly and quickly down once on the applicator to release the spray. Breath out through our mouth Wipe nasal applicator wiht clean tissue and replace cap. Use the bottle for the labeled # of sprays and then discard. DO not blow nose directly after
59
Eye drop counseling
Before you open the bottle, shake it a few times. Gels should be inverted and shaken once prior to use. Bend your neck back so that you are looking up. Use one finger to pull down your lower eyelid. Without letting the tip of the bottle touch your eye, release 1 drop of the medication into the space between your eye and your lower eyelid. After squeezing in the drop, close your eye and press a finger between your eye and the top of your nose for at least 1 minute. If you need to use more than 1 drop, wait 5 minutes between drops. Wait at least 5-10 meds before a second medication, 10 minutes before a gel.
60
Eye drop preservative
If the eye drop contains the preservative benzalkonium chloride (BAK) and you where soft contact lenses, remove lenses prior to administration and wait 15 minutes to reinsert them.
61
Ear drop counseling
If cold, gently shake the bottle or roll it in your hands for 1-2 minutes. Lie down or tilt head up do that affected ear faces up. Gently pull the earlobe up and back for adults to straighten the ear canal. Pull down and back fr children <3 years. Administer the prescribed number of drops into the ear canal and keep the ear facing up for about 5 minutes to allow the medication to coat the ear canal.
62
Best results for rectal products
For best results, empty the bowel immediately before use
63
Enema patient counseling
Remove the bottle from one pouch and shake well. Remove the protective sheath from the applicator tip. Hold the bottle at the neck to prevent any of the medication from being discharged. Best results are obtained from lying on the left side with the left leg extended and the right leg flexed forward for balance. Gently insert the medication or applicator tip into the rectum, pointed slightly toward the navel to prevent damage to the rectal wall. Grasp the bottle firmly and then tilt slightly so that the nozzle is aimed towards the back; squeeze slowly to instill the medication. Remain in position for at least 30 minutes or preferably all night
64
Suppositories patient counseling
Detach one suppository from the strip. Remove the foil wrapper carefully while holding the suppository upright. Do not handle the suppository too much; heat from your hands will cause it to melt. Insert the suppository, with the pointed end first, completely into the rectum, using gentle pressure. For best results, keep the suppository in your rectum for at least 1-3 hours
65
Inhalations patient counseling
Drug is delivered directly to the lung and minimizes systemic AR

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