Chapter 5: Integumentary System Flashcards
stratum corneum
1st superficial; 20-30 layers of dead cells filled w keratin; glycolipids for waterproofing; stratified cells called cornified/horny cells
stratum lucidum
2nd superficial; only thick skin; tonofilaments formed by keratohyalin granules sticking to keratin filaments
stratum granulosum
3rd superficial; keratinization occurs; lamellar granules produce glycolipids; keratohyalin involved in keratin formation in more superficial layers
keratinization
keratinocytes become dominated by keratin and their organelles decompose, the cell membrane gets thicker, a form of apoptosis
stratum spinosum
4th superficial; keratinocytes shrunk but held on by deosmosomes giving the “prickly” appearance; cells contain thick bundles of intermediate filaments called pre-keratin
stratum basale
5th superficial; deepest layer; site of rapid mitotic division producing new keratinocytes; melanocytes present; and some dendritic cells
keratinocytes
epidermis-produce keratin
melanocytes
epidermis-produce melanin, form melanosome granules that move and associate to the superficial side of keratinocytes
dendritic cells
epidermis-also “langerhans cells” derived from bone marrow playing a part in the immune system
tactile (merkel) cells
epidermis-at the epidermal-dermal junction, sensory receptors for touch
epidermis
outer protective covering of the skin; avascular
dermis
tough leathery layer full of fibrous connective tissue, fibroblasts, macrophages, mast cells, white blood cells, hair follicles, oil/sweat glands
fibroblast
produces collagen and other fibers
macrophages
large phagocytotic cell
mast cells
release histamine, play a part in immune response and attracting other WBC
cleavage (tension) lines
formed by less dense regions in the pockets of adipose, collagen fiber networks in the ECF of the cutaneous plexus; externally invisible - run longitudinally in the skin of the head and limbs, run circularly around the neck and the trunk
cutaneous plexus
nourishes the reticular layer of the dermis, ECF has pockets of adipose tissue, and bundles of interlacing collagen
clinical importance of cleavage lines
important for surgeons because when they make an incision parallel to these lines, the skin doesn’t gape as much and heals faster
flexure lines
externally visible, e.g. creases of the palms; created at or near joints where the dermis is more securely attached to the deeper structures below
papillary layer
dermis-thin layer made up of interlacing collagen and other fibers heavily invested w small blood vessels creating a loosely woven mat allowing phagocytes and defensive cells to patrol for bacteria
dermal papillae
indent the epidermis, can contain capillary loops, pain receptors, tactile receptors, or tactile (Meissner’s) corpuscles
friction ridges
formed by the epidermal and dermal ridges created by dermal papillae in thick skin; enhance grip ability and sense of touch e.g. fingertips
reticular layer
80% of thickness, coarse irregular arrangement of dense connective tissue, collagen fibers provide strength and resiliency, collagen also binds water for moisture, elastic fibers allow for stretch-recoil
melanin
tyrosine polymer produced my tyrosinase of melanocytes - distributed to keratinocytes of the stratum basale
why do people have different skin colors?
we all have relatively the same # of melanocytes but differences in skin color arise from the different amount and types of melanin produced
tanning
visible darkening of skin - exposure to UV radiation causes faster DNA repair of photodamaged cells, triggers greater production of melanin
carotene
yellow-orangey pigment - concentrated in thicker stratum corneum (palms and soles) and adipose tissue of the hypodermis
hemoglobin
binds oxygen in blood - turns red
pigment indicators of disease states
C-cyanosis E-erythema P-pallor or blanching J-jaundice B-bronzing B-bruising
cyanosis
bluing: lack of oxygen to hemoglobin - heart failure, severe respiratory disorders