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Neurobiology > Chapter 5 > Flashcards

Chapter 5 Flashcards

1
Q

Synapsin function

A

keeps vesicles tethered to reserve pool

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2
Q

Ca2+/Calmodulin dependent protein kinase

A

mobilizes reserve pool vesicles

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3
Q

NSF and SNAPs

A

prime synaptic vesicles for fusion

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4
Q

Types of SNAREs and function

A
  1. SNAP-25
  2. Syntaxin
  3. Synaptobrevin

promote membrane fusion

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5
Q

SNAP-25 location

A

plasma membrane

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6
Q

syntaxin location

A

plasma membrane

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7
Q

synaptobrevin

A

synaptic vesicle membrane

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8
Q

synaptotagmin function

A

Ca2+ regulation of transmitter release , binds Ca2+ which acts as a sensor to trigger vesicle fusion, on vesicle membrane

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9
Q

steps of endocytosis for vesicle uptake

A
  1. adaptor proteins (AP2 and AP180) connect clathrin to vesicle membrane
  2. clathrin triskelia assembles coat and curves membrane
  3. clathrin cage constricts lipid stalk
  4. dynamin pinches off lipid stalk
  5. coated vesicle translocated by actin
  6. Hsc 70 and auxillin uncoat vesicle
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10
Q

Synaptojanin function

A

important for vesicle uncoating

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11
Q

introduction of receptor molecules by who?

A

John Langley

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12
Q

2 types of neurotransmitters

A
  1. small molecule neurotransmitters - rapid

2. neuropeptides - slow ongoing

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13
Q

where does synthesis of small molecule neurotransmitters occur?

A

presynaptic terminals

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14
Q

where does synthesis of neuropeptides occur?

A

cell body

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15
Q

precursors to synaptic vesicles are originally produced where?

A

ER and Golgi

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16
Q

1st indication of presynaptic Ca2+ channels was by who?

A

Katz and Miledi

17
Q

Voltage gated Ca2+ channels discovered by…

A

Rodolfo Llinás

18
Q

what does sarin inhibit?

A

acetylcholinesterase

19
Q

botulism and tetanus toxins affect what?

A

SNARE proteins involved in vesicle fusion

20
Q

another process for endocytosis that is not clathrin mediated

A

lipid rafts

21
Q

what does keppra do?

A

anti-epileptic blocks high voltage Ca2+ channels, binds to a SV2A

Neurobiology (3 decks)

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