Chapter 5 Flashcards
Synapsin function
keeps vesicles tethered to reserve pool
Ca2+/Calmodulin dependent protein kinase
mobilizes reserve pool vesicles
NSF and SNAPs
prime synaptic vesicles for fusion
Types of SNAREs and function
- SNAP-25
- Syntaxin
- Synaptobrevin
promote membrane fusion
SNAP-25 location
plasma membrane
syntaxin location
plasma membrane
synaptobrevin
synaptic vesicle membrane
synaptotagmin function
Ca2+ regulation of transmitter release , binds Ca2+ which acts as a sensor to trigger vesicle fusion, on vesicle membrane
steps of endocytosis for vesicle uptake
- adaptor proteins (AP2 and AP180) connect clathrin to vesicle membrane
- clathrin triskelia assembles coat and curves membrane
- clathrin cage constricts lipid stalk
- dynamin pinches off lipid stalk
- coated vesicle translocated by actin
- Hsc 70 and auxillin uncoat vesicle
Synaptojanin function
important for vesicle uncoating
introduction of receptor molecules by who?
John Langley
2 types of neurotransmitters
- small molecule neurotransmitters - rapid
2. neuropeptides - slow ongoing
where does synthesis of small molecule neurotransmitters occur?
presynaptic terminals
where does synthesis of neuropeptides occur?
cell body
precursors to synaptic vesicles are originally produced where?
ER and Golgi
1st indication of presynaptic Ca2+ channels was by who?
Katz and Miledi
Voltage gated Ca2+ channels discovered by…
Rodolfo Llinás
what does sarin inhibit?
acetylcholinesterase
botulism and tetanus toxins affect what?
SNARE proteins involved in vesicle fusion
another process for endocytosis that is not clathrin mediated
lipid rafts
what does keppra do?
anti-epileptic blocks high voltage Ca2+ channels, binds to a SV2A
