Chapter 46: Renal/Urologic Flashcards
CULTURAL & ETHNIC HEALTH DISPARITIES
- Urinary tract calculi are more common among whites than African Americans.
- Uric acid stones are more common in Jewish men.
- Bladder cancer has a higher incidence among white men than African American men.
- In all ethnic groups, bladder cancer affects men about three times more often than women.
- Urinary incontinence is underreported because culturally it is seen as a social hygiene problem causing patient embarrassment.
Escherichia coli is the most common pathogen causing a UTI
and is primarily seen in women. Bacterial counts
of 105 colony-forming units per milliliter (CFU/mL) or higher typically indicate a clinically significant UTI. However, counts as low as 102 to 103 CFU/mL in a person with signs and symptoms
are indicative of UTI.
Specific terms
are used to further delineate the location of a UTI. For example
pyelonephritis implies inflammation (usually caused by infection) of the renal parenchyma and collecting system, cystitis indicates inflammation of the bladder, and urethritis means inflammation of the urethra. Urosepsis is a UTI that has spreadsystemically and is a life-threatening condition requiring emergency
treatment
Lower urinary tract symptoms (LUTS) are experienced in
patients who have UTIs of the upper urinary tract, as well as those confined to the lower tract. Symptoms are related to either bladder storage or bladder emptying.
dysuria, frequent urination (more than every 2 hours), urgency, and suprapubic discomfort or pressure. The urine may contain grossly visible blood (hematuria)
or sediment, giving it a cloudy appearance. Flank pain,
chills, and fever indicate an infection involving the upperurinary tract (pyelonephritis)
UTI, initially obtain a dipstick urinalysis to identify the presence of nitrites (indicating bacteriuria), white blood cells (WBCs), and leukocyte esterase (an enzyme present in WBCs indicating pyuria). These findings can be confirmed by microscopic urinalysis.
After confirmation of bacteriuria and pyuria, a urine culture may be obtained. A urine culture is indicated in complicated or HAI UTIs, persistent bacteriuria, or frequently recurring UTIs (more than two or three episodes per year). Urine may also be cultured when the
infection is unresponsive to empiric therapy or the diagnosis is questionable
First-choice drugs to empirically treat uncomplicated or
initial UTIs are
trimethoprim/sulfamethoxazole (TMP/SMX)
(Bactrim, Septra), nitrofurantoin (Macrodantin), and fosfomycin (Monurol). TMP/SMX has the advantages of being relatively inexpensive and being taken twice daily.
treat complicated UTIs.
These drugs include ciprofloxacin (Cipro), levofloxacin (Levaquin), norfloxacin (Noroxin), ofloxacin (Floxin), and gatifloxacin (Tequin). In patients with UTIs secondary to fungi, amphotericin or fluconazole (Diflucan) is the preferred therapy.
DRUG ALERT: Nitrofurantoin (Furadantin, Macrodantin)
• Avoid sunlight. Use sunscreen, and wear protective clothing.
• Notify health care provider immediately if fever, chills, cough,
chest pain, dyspnea, rash, or numbness or tingling of fingers or toes
develops.
Nursing diagnoses for the patient with a UTI may include, but are not limited to, the following: pg 1067
- Impaired urinary elimination related to the effects of UTI
* Readiness for enhanced self-health management
Health promotion activities include teaching preventive measures such as
(1) emptying the bladder regularly and completely, (2) evacuating th bowel regularly, (3) wiping the perineal area from front to back after urination and defecation, and (4) drinking an adequate amount of liquid each day.
It is important to recognize individuals
who are at risk for a UTI. These people include
debilitated persons, older adults, patients who are immunocompromised (e.g., cancer, human immunodeficiency virus [HIV], diabetes mellitus), and patients treated with immunosuppressive drugs
or corticosteroids.
Teach patients to promptly report any of the following to their health care provider:
(1) persistence of bothersome LUTS beyond the antibiotic
treatment course, (2) onset of flank pain, or (3) fever
Pyelonephritis usually begins with colonization and infection of the lower urinary tract via the ascending urethral route.
Bacteria normally found in the intestinal tract, such as E. coli or Proteus, Klebsiella, or Enterobacter species, frequently cause pyelonephritis.
A preexisting factor is often present such as vesicoureteral reflux (retrograde, or backward, movement of urine from lower to upper urinary tract) or dysfunction of the lower urinary tract (e.g., obstruction from benign prostatic hyperplasia [BPH], a stricture, a urinary stone).
Ultrasonography of the urinary system may be performed
to identify anatomic abnormalities,
hydronephrosis, renal abscesses, or an obstructing stone.
CT urograms are also used to assess for signs of infection in the kidney and complications of yelonephritis, such as impaired renal function, scarring,
chronic pyelonephritis, or abscesses.
The overall goals are that the patient with pyelonephritis will have
(1) normal renal function, (2) normal body temperature,
(3) no complications, (4) relief of pain, and (5) no recurrence of symptoms.
In chronic pyelonephritis the kidneys become small, atrophic, and shrunken and lose function due to fibrosis (scarring).
Radiologic imaging and a biopsy, rather than clinical features, are used to confirm the diagnosis of chronic pyelonephritis. Imaging studies reveal a small, fibrotic kidney. The collecting system may be small or hydronephrotic. Biopsy results indicate the loss of functioning nephrons, infiltration of the parenchyma
with inflammatory cells, and fibrosis.
Urethritis is an inflammation of the urethra. Causes of urethritis include
a bacterial or viral infection, Trichomonas and monilial infection (especially in women), chlamydial infection, and gonorrhea (especially in men).
Urethral diverticula are localized outpouchings of the urethra.
Most often they result from enlargement of obstructed periurethral glands.
Interstitial cystitis (IC) is a chronic, painful inflammatory disease of the bladder characterized by symptoms of urgency, frequency, and pain in the bladder and/or pelvis.
Painful bladder syndrome (PBS) is suprapubic pain related to bladder filling.
The term IC/PBS refers to cases of urinary pain that cannot be attributed to other causes such as infection or urinary calculi.
Because the etiology of IC/PBS is unknown, no single treatment consistently reverses or relieves symptoms. Various therapies have been effective, including nutritional and drug therapy.18,19 Surgical therapy is rarely indicated.
Elimination of foods and beverages that are likely to irritate the bladder may provide some relief from symptoms. Typical bladder irritants include caffeine; alcohol; citrus products; aged cheeses; nuts; foods containing vinegar, curries, or hot peppers; and foods or beverages, including fruits (cranberries), likely to
lower urinary pH.
The clinical manifestations of APSGN include
Acute poststreptococcal glomerulonephritis (APSGN)
generalized body edema, hypertension, oliguria, hematuria with a smoky or rusty appearance, and proteinuria.
The diagnosis of APSGN is based on a complete history and physical examination.
Dipstick urinalysis and urine sediment microscopy reveal
erythrocytes in significant numbers. Erythrocyte casts are
highly suggestive of APSGN. Proteinuria may range from mild to severe. Blood tests include blood urea nitrogen (BUN) and serum creatinine to assess the extent of renal impairment.
One of the most important ways to prevent APSGN is to
encourage early diagnosis and treatment of sore throats and
skin lesions.
If streptococci are found in the culture, treatment
with appropriate antibiotic therapy (usually penicillin) is essential. Encourage the patient to take the full course of antibiotics to ensure that the bacteria have been eradicated. Good personal hygiene is an important factor in preventing the spread of cutaneous streptococcal infections
Goodpasture syndrome is an autoimmune disease characterized by circulating antibodies against glomerular and alveolar basement membrane.
Damage to the kidneys and lungs results when binding of the antibody causes an inflammatory reaction mediated by complement activation
Goodpasture syndrome is a rare disease that is mostly found in young male smokers. The clinical manifestations include
flulike symptoms with pulmonary symptoms such as cough, mild shortness of breath, hemoptysis, crackles, rhonchi, and pulmonary insufficiency. Renal involvement causes hematuria, weakness, pallor, anemia, and renal failure. Pulmonary hemorrhage usually occurs and may precede glomerular abnormalities by
weeks or months.
RPGN can occur in a variety of situations:
(1) as a complication
of inflammatory or infectious disease (e.g., APSGN), (2) as
a complication of a systemic disease (e.g., systemic lupus erythematosus),
(3) as an idiopathic disease, or (4) with the use of
certain drugs (e.g., penicillamine).
Nephrotic syndrome results when the glomerulus is excessively permeable to plasma protein, causing proteinuria that leads to low plasma albumin and tissue edema.
Immune responses, both humoral and cellular, are altered
in nephrotic syndrome. As a result, infection is a primary
cause of morbidity and mortality. Calcium and skeletal abnormalities may occur, including hypocalcemia, blunted calcium response to parathyroid hormone, hyperparathyroidism, and osteomalacia.
Crystals, when in a supersaturated concentration, can precipitate and unite to form a stone.
A mucoprotein is formed in the kidneys as a matrix for the stone. Urinary pH, solute load, and inhibitors in the urine affect the formation of stones. The higher the pH (alkaline), the less soluble are calcium and phosphate. The lower the pH (acidic), the less soluble are uric acid and cystine. When a substance is not very soluble in fluid, it is more likely to precipitate out of solution
The term calculus refers to the stone, and lithiasis refers to stone
formation. The five major categories of stones are
(1) calcium
phosphate, (2) calcium oxalate, (3) uric acid, (4) cystine, and
(5) struvite (magnesium ammonium phosphate)
Renal colic is the term used for the sharp, severe pain, which results from the stretching, dilation, and spasm of the ureter in response to the obstructing stone. Nausea and vomiting may occur due to the severe pain
Urinary stones cause clinical manifestations when they
obstruct urinary flow. Common sites of obstruction are at the UPJ (where the renal pelvis narrows into the ureter) and at the ureterovesical junction (UVJ).
Indications for endourologic, lithotripsy, or open surgical
stone removal include the following:
(1) stones too large for spontaneous passage (usually greater than 7 mm); (2) stones associated with bacteriuria or symptomatic infection; (3) stones causing impaired renal function; (4) stones causing persistent pain, nausea, or paralytic ileus; (5) inability of patient to be treated medically; and (6) patient with only one kidney.
Purine*
uric acid is by product
High: Sardines, herring, mussels, liver, kidney, goose, venison, meat soups, sweetbreads Moderate: Chicken, salmon, crab, veal, mutton, bacon, pork, beef, ham