Chapter 44 Antiinflammatory Drugs

Question 1

List the 4 properties of NSAIDs

Non-steroidal Antiinflammatory Drugs

Answer 1

Analgesic
Antiinflammatory
Antipyretic
Antirheumatic

Question 2

Which type of tablets should definitely not be crushed or chewed?

Answer 2

Enteric-coated tablets

Question 3

We do NOT give salicylates to children and teenagers because of the risk of what syndrome?

Answer 3

risk of Reye’s Syndrome

Question 4

The inflammatory process can be triggered by one of two pathways. Name them

Answer 4

Prostaglandin Pathway (PG)
Leukotriene Pathway (LT)

Question 5

List the 5 chemical categories of NSAIDs

Answer 5

• Salicylates
• Acetic acid derivatives
• COX-2 Inhibitors
• Enolic acid derivatives
• Propionic acid Derivatives

Question 6

What are the other functions of Salicylates other than inhibiting inflammation and fever?

Answer 6

prevent platelet aggregation

so they could help break down a thrombus (a blood clot)

Question 7

Which specific category of NSAID would these two medications fall under?
indomethacin (Indocin) & Ketorolac (Toradol)

Answer 7

Acetic acids

Question 8

What is celecoxib (Celebrex)?

Answer 8

the only remaining COX-2 Inhibitor

Question 9

What is Celebrex (celecoxib) used specifically for?

Answer 9

osteoarthritis

people are in pain due to inflammation in the joint

Question 10

What are some of the contraindications of Celebrex?

who will have serious side effects if they take it?

Answer 10

People with:
liver function impairment
Renal failure
a history of GI Bleeding

Question 11

What is the main Propionic acid that was mentioned in the PP lecture?

Answer 11

ibuprofen (ex: Motrin, Advil)

Question 12

What are the NSAID Indications?

Answer 12

mild to moderate pain (Analgesia)
Antigout
Antiinflammatory
Antipyretic (fever reducer)
Relief of vascular headache
platelet inhibition (aspirin)

Question 13

What is the name of the common Salicylate?

hint: sounds like Salicylate

Answer 13

Salicylic acid (aspirin)

Question 14

What does Salicylic acid inhibit the formation of?

Answer 14

prostiglandins

therefore inhibits inflammation, pain, and fever

Question 15

What are the adverse effects of taking NSAIDs?
Gastrointestinal:
Renal:
Cardiovascular:

Answer 15

Gastrointestinal : dyspepsia, heartburn, GI bleeding,
mucosal lesions in mouth
Renal: reduced creatinine clearance
tubular necrosis with renal failure
Cardiovascular: noncardiogenic pulmonary edema