Chapter 43 - Antiulcer Drugs Flashcards
Ulcer that occurs in upper GI tract
Peptic ulcer
Peptic ulcers occur when there is a hyper secretion of what ?
Hydrochloric acid and pepsin
Inflammation or erosion of esophageal mucosa
GERD
*Genetic influences
*bacteria
*environmental factors
*certain drugs
*Stress
*H.Pylori
Are all predisposing factors for what ?
Peptic ulcer disease
ANTACIDS
What do they do?
Neutralize hydrochloric acid & reduce pepsin activity
ANTACIDS
what are you assessing?
Electrolytes ( especially calcium + phosphate )
Renal function
ANTACIDS
Interventions
- Monitor electrolytes
- Give 2h after other meds
- Give with water
ANTACIDS
what are you teaching ?
- Take antacids 1-3 hours after meals
- Report pain , cough, vomiting blood
- Avoid taking w/milk or foods high in vitamin D
- Avoid taking with other oral drugs
HISTAMINE 2 Blockers
End in what?
~Tidine
Histamine 2 Blockers
- what do they do?
- what are there side effects?
- ) prevent acid reflux in the esophagus
2. ) headache , < libido , gynecomastia , erectile dysfunction
Histamine 2 Blockers
Teach pt what?
Report pain , coughing or vomiting blood
Histamine 2 blockers
Contraindications?
Older adults have < gastric acid and they need reduced doses of this drug.
Ranitidine (H 2blocker)
1.) how long until peak concentration?
2-3 hours
Ranitidine (h2blocker)
while on this drug,increase what in diet?
Foods high in vitamin b12
Proton pump inhibitors
1.) what do they do?
Suppress gastric acid secretion
Proton pump inhibitors
What do they end in ?
~Prazole
Proton pump inhibitors
What should you monitor?
Monitor liver enzymes and drug interactions
Proton pump inhibitors
Side effects ?
Headache
Diarrhea
Abdominal rash
Pepsin inhibitors (sulcralfate)
What is it / what does it do?
Non absorbable drug that combines with protein to form protective layer over ulcer
Pepsin inhibitor ( sulcralfate)
Side effect ?
Constipation
Pepsin inhibitor (sulcralfate)
Contraindications?
Give antacids 30 minutes before or after administering sulcralfate
Sulcralfate does not do what ?
Neutralize acid or < acid secretions
Prostaglandin analogue anti ulcer (misoprostol)
What does it do?
Prevents NSAID induced gastric ulcers
Prostaglandin analogue anti ulcer (misoprostol)
Side effects ?
N/V/D , gas , menstrual spotting
