Chapter 43 - Antiulcer Drugs

Question 1

Ulcer that occurs in upper GI tract

Answer 1

Peptic ulcer

Question 2

Peptic ulcers occur when there is a hyper secretion of what ?

Answer 2

Hydrochloric acid and pepsin

Question 3

Inflammation or erosion of esophageal mucosa

Answer 3

GERD

Question 4

*Genetic influences
*bacteria
*environmental factors
*certain drugs
*Stress
*H.Pylori
Are all predisposing factors for what ?

Answer 4

Peptic ulcer disease

Question 5

ANTACIDS

What do they do?

Answer 5

Neutralize hydrochloric acid & reduce pepsin activity

Question 6

ANTACIDS

what are you assessing?

Answer 6

Electrolytes ( especially calcium + phosphate )

Renal function

Question 7

ANTACIDS

Interventions

Answer 7

• Monitor electrolytes
• Give 2h after other meds
• Give with water

Question 8

ANTACIDS

what are you teaching ?

Answer 8

• Take antacids 1-3 hours after meals
• Report pain , cough, vomiting blood
• Avoid taking w/milk or foods high in vitamin D
• Avoid taking with other oral drugs

Question 9

HISTAMINE 2 Blockers

End in what?

Answer 9

~Tidine

Question 10

Histamine 2 Blockers

• what do they do?
• what are there side effects?

Answer 10

1. ) prevent acid reflux in the esophagus

2. ) headache , < libido , gynecomastia , erectile dysfunction

Question 11

Histamine 2 Blockers

Teach pt what?

Answer 11

Report pain , coughing or vomiting blood

Question 12

Histamine 2 blockers

Contraindications?

Answer 12

Older adults have < gastric acid and they need reduced doses of this drug.

Question 13

Ranitidine (H 2blocker)

1.) how long until peak concentration?

Answer 13

2-3 hours

Question 14

Ranitidine (h2blocker)

while on this drug,increase what in diet?

Answer 14

Foods high in vitamin b12

Question 15

Proton pump inhibitors

1.) what do they do?

Answer 15

Suppress gastric acid secretion

Question 16

Proton pump inhibitors

What do they end in ?

Answer 16

~Prazole

Question 17

Proton pump inhibitors

What should you monitor?

Answer 17

Monitor liver enzymes and drug interactions

Question 18

Proton pump inhibitors

Side effects ?

Answer 18

Headache
Diarrhea
Abdominal rash

Question 19

Pepsin inhibitors (sulcralfate)

What is it / what does it do?

Answer 19

Non absorbable drug that combines with protein to form protective layer over ulcer

Question 20

Pepsin inhibitor ( sulcralfate)

Side effect ?

Answer 20

Constipation

Question 21

Pepsin inhibitor (sulcralfate)

Contraindications?

Answer 21

Give antacids 30 minutes before or after administering sulcralfate

Question 22

Sulcralfate does not do what ?

Answer 22

Neutralize acid or < acid secretions

Question 23

Prostaglandin analogue anti ulcer (misoprostol)

What does it do?

Answer 23

Prevents NSAID induced gastric ulcers

Question 24

Prostaglandin analogue anti ulcer (misoprostol)

Side effects ?

Answer 24

N/V/D , gas , menstrual spotting

Question 25

Avoid prostaglandin analogue anti ulcer (misoprostol) if what?

Answer 25

You’re pregnant or of child bearing age