Chapter 4: General Physiology Flashcards

1
Q

Hindbrain

A

medulla (natural rhythms)
pons (general awareness/awakeness, simple sensory processes)
cerebellum (muscle coordination)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Midbrain

A

tectum (auditory)

tegmentum (eye/motor movements)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Forebrain

A

thalamus (higher input of sensory systems, integrated b/f entering cortex)
hypothalamus (regulator of motivation and emotion)
pituitary gland (send regulatory hormones to this gland which sends other hormones)
basal ganglia (motor control, muscle movement)
limbic system
cerebral cortex (less evolutionary conserved, higher processing of sensory)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hypothalamus

Responsive to:

A

Light (photosensitive) –circadian rhythms
Olfactory stimuli (pheromones)
Steroids (reproductive steroids from gonad and adrenal gland)
Neural info (processing of info from CNS & PNS)
Input from autonomic NS
Various peptide hormones and other subs from blood (receiving and regulating)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Hypothalamus

Controls influences upon:

A
  • Autonomic NS
  • Hormones from pituitary gland
  • Aspects of bodily homeostasis
  • Hunger, thirst, sex, maternal behaviour, fear, rage, etc.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Pituitary Gland

Anterior vs Posterior

A

Hypothalamus controls what hormones this gland releases (via signals)

Anterior (towards front) –connected to hypothalamus thru neuro-secretions (chemical signalling)
Hypothalamus releases hormones into blood, sensed by anterior which releases another hormone

Posterior (back) –made up of nervous tissue, neuronal inputs from hypothalamus (electrical signalling)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Sympathetic NS: flight/fight response

Arousal and energy expenditure (catabolic)

A

Increase HR and respiratory rate
Increase BP
Inhibits digestion
Decrease blood flow to digestive tract and skin
Increase blood flow to muscle and lungs
Dilation of pupils (take in more light, info from enviro)
Causes epinephrine release from adrenal glands

Piloerection (or goosebumps-hair stand on end –makes us look bigger)
Spontaneous urination and defecation (more common in smaller mammals)

**Response very quick

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Parasympathetic NS: rest and digest

Calming, relaxation, energy storage (anabolic)

A
Decrease HR and respiratory rate
Promotes digestion
Increased blood flow to digestive tract
Stimulates salivary gland secretion
Involved in sleep, sexual responses 

**Fires slowly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Sympathetic NS Synapsing

A

Spinal cord: thoracic, lumber

Neuron meets a second neuron, synapse, and then goes to an organ
- 1st neuron=pre-synaptic, 2nd neuron=post-synaptic
Ganglia: group/cluster of nerve cells=sympathetic chain (all neurons leaving the spinal cord in these regions pass thru this chain)
- Some neurons will synapse IN in chain ganglia, other will go through it

o Presynaptic release ACh
o Postsynaptic release norepinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Parasympathetic NS Synapsing

A

Spinal cord: cranial (nerves), sacral

Nerves leaving the spinal cord synapse again very close to the organs

o Presynaptic release ACh
o Postsynaptic release ACh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Medulla

adrenal gland

A

rapidly secretes catecholamines into bloodstream in response to systemic NS (epinephrine and norepinephrine)
in response to stress/fear
very quick

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cortex

adrenal gland

A

slowly secretes steroids (cortisol, DHEA) in response to chemical stimulation (especially ACTH from pituitary)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Hormone

A

substance released into (and travels thru) the bloodstream that communicates with receptors at some distant site(s)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Neurotransmitter

A

substance released into the synapse when a presynaptic neuron fires, picked up by a receptor on the dendritic membrane of the postsynaptic neuron, affecting the probability that the postsynaptic neuron will fire
(excitatory or inhibitory influences)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Neuromodulator

A

substance in brain that changes response of neuron to some other factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Pheromone

A

substance emitted or excreted by one individual that affects physiology or behaviour of another member of its species (ex: dog urine marking)

17
Q

Steroid Hormones

A

derived from cholesterol
generally slow acting and excreted slowly
small lipid soluble molecules that travel throughout body
act on intracellular receptors
May pass BBB
May bind to carrier proteins in blood
Receptors in various peripheral sites; in the brain predominantly in limbic system
Mainly from: Gonads & Adrenal cortex
Functions include reproduction, stress, and metabolism

18
Q

Peptide Hormones

A

consist of various chains of aa derived from pr-
generally fast acting and excreted quickly
large fragile & water soluble
act on extracellular receptors
Do NOT pass BBB
Produced mostly from: Hypothalamus, Anterior & Posterior Pituitary

Peptides from the pituitary control the gonads, adrenal cortex, and thyroid
The anterior pituitary is controlled chemically by peptides in local circulation from hypothalamus

There are many peripheral peptides with relevance to behaviour:
• Insulin and glucagon from pancreas
• CCK & ghrelin from gut
• Leptin from adipose cells
Do not flow freely to all parts of the body, often because of large molecular size
Those produced in periphery may not reach the brain

19
Q

Monoamine Hormones

A
derived of single aa
generally fast acting and excreted quickly
very small & water soluble
act on extracellular receptors
Do NOT pass blood-brain barrier
Generally do not reach brain

Catecholamines from adrenal medulla: epinephrine (adrenaline), norepinephrine (noradrenaline)
Indoleamines from pineal gland: melatonin

20
Q

Monoamine NTs

A

Derived from single aa
Tryptophan–> indoleamines (5-HT –> melatonin)
Tyrosine –> catecholamines (DA –> NE –> epinephrine)

Catecholamine NTs: dopamine (DA), norepinephrine (NE)
Indoleamine NTs: serotonin (5-HT)
Other: glutamate, GABA, histamine, glycine

21
Q

Catecholamines

A
derived from tyrosine
Hormones from adrenal medulla: epinephrine, norepinephrine
NT: norepinephrine, dopamine 
•	DA is more abundant than NE
MAO and COMT degrade these hormones/NTs
22
Q

Dopamine

Path
Role

A

produced ventral tegmental area (VTA)
travel to medial forebrain bundle (MFB)
released into nucleus accumbens

DA circuitry is critical in attention, concentration, general arousal, wakefulness, reward, and addiction. Stimulant drugs like amphetamines, cocaine, and Ritalin (methylphenidate) all activate DA systems.

23
Q

Norepinephrine

Path
Role

A

produced in locus coeruleus (LC)
medial forebrain bundle (MFB)
limbic system, neocortex

Adrenaline and NE are released as hormones into the bloodstream, facilitating sympathetic reflexes.

24
Q

Indoleamines

A

synthesized from tryptophan

  • Hormones from pineal: melatonin
  • NTs: serotonin
  • MAO degrades these hormones/NTs
25
Q

Serotonin

Path
Role

A

Concentrated in Raphe nuclei
MFB
Thalamus, Basal Ganglia, Limbic system, Neocortex

highly (but complexly) involved in affect, cognition, arousal, and other processes.

26
Q

Melatonin

A

pineal secretes more melatonin in darkness, regulated by suprachiasmatic nucleus of hypothalamus

27
Q

Large Neutral Amino Acid Transporter

A
  • Supplies large neutral aa to brain, which otherwise does not directly receive them from circulation
  • Transports tyrosine, phenylalanine, tryptophan, methionine, and branch-chained aa
  • These aa all compete for transporter, so large quantity of one aa can greatly limit the amount of others entering brain
28
Q

Acetylcholine (ACh)

A

not derived from aa

Neurotransmitter at neuromuscular junctions, autonomic ganglia, parasympathetic nerve endings, and throughout the CNS (hippocampus, parts of the thalamus, caudate, brain stem, lateral geniculate).

29
Q

Serotonin, Tryptophan & Diet

A

sensitive to diet, and people tend to like foods that contain tryptophan and various tryptamines (e.g. chocolate, red wine).
o Tryptophan loading in diet increase serotonin levels
o Serotonin levels decrease after ingestion of aa beverage devoid of tryptophan
o Want to keep aspartame levels down so tryptophan levels are not depleted