Chapter 4

Question 1

List the six steps of neurotransmission and two drugs that affect each step (one agonist, one antagonist).

Answer 1

1. Neurotransmitter synthesis
   - Allylglycine (Antagonist)
   - L-DOPA (Agonist)
2. Neurotransmitter vesicle storage;
   - Reserpine (Antagonist)
   - Choline (Agonist)
3. Release of NT into synaptic cleft;
   - Botulinum (antagonist)
   - Amphetamine (agonist)
4. Neurotransmitter to auto receptor binding;
   - Apomorphine (antagonist)
   - Roxindole (agonist)
5. Post Synaptic binding;
   - Curare (Antagonist)
   - Nicotine (Agonist)
6. Reuptake and Degredation of NT.
   - Progenolone Sulfate (Antagonist)
   - Cocaine (Agonist)

Question 2

What is the MOA for Allylglycine?

Answer 2

Inhibits enzyme glutemate decarboxylase which blocks GABA synthesis, therefore Allylglycine is a GABA antagonist.

Question 3

What is the MOA for L-DOPA?

Answer 3

L-DOPA is a dopamine precurser, therefore L-DOPA is a Dopamine agonist.

Question 4

What is the MOA of Reserpine?

Answer 4

Reserpine Irreversibly blocks the vesicular monoamine transporter which normally transports NE, Serotonin and dopamine in the presynaptic nerve terminal into presynaptic vesicles. Therefore, Reserpine is an NE, Serotonin and Dopamine antagonist.

Question 5

What is the MOA of Choline?

Answer 5

Choline stores Acytlcholine in vesicles, therefore, Choline is an Acytlcholine agonist.

Question 6

What is the MOA of Botulinum?

Answer 6

Anchors to vesicle junction inhibiting vesicle fusion to pie synaptic membrane. therefore it is an acetylcholine antagonist.

Question 7

What is the MO of Amphetamine?

Answer 7

Amphetamine stimulates NE release. Therefore amphetamine is a NE agonist

Question 8

What is the MOA for Apomorphine?

Answer 8

Activates dopamine receptors, therefore it is a dopamine antagonist.

Question 9

What is the MOA for Roxindole?

Answer 9

Agonizes the 5-1-HT receptor

Question 10

What is the MOA for Curare?

Answer 10

Blocks nicotine receptors, therefore it is an acetylcholine antagonist.

Question 11

What is the MOA Nicotine?

Answer 11

Nicotine stimulates nicotinic receptors, therefore it is an acetylcholine agonist.

Question 12

What is the MOA for Progebolone Sulfate?

Answer 12

Increases binding to GABA degrading enzymes. Therefore, Progenolone sulfate is a GABA antagonist

Question 13

What is the MOA for cocaine?

Answer 13

Cocaine blocks reuptake transport proteins. Therefore, cocaine is a dopamine agonist.