Chapter 3: The Complement System Flashcards
1
Q
Complement system general fx
A
> 30 different proteins in blood plasma –> cascade of proteolytic cleavage reactions –> tag pathogens for phagocytosis OR directly kill pathogens by creating holes in their membranes
2
Q
C3 protein
A
3
Q
C3a
A
smaller fragment, anaphylatoxin induces inflammation
4
Q
C3b
A
5
Q
Alternative pathway
A
spontaneous, first to act, initiated and prepared for when pathogen enters body
6
Q
Lectin pathway
A
second to act, activated by recognition of bacterial oligosaccharides ending in mannose, fucose
7
Q
Classical pathway
A
8
Q
How is the alternative pathway initiated?
A
9
Q
The binding of C3b is __________.
A
nonspecific
10
Q
DAF (protein)
A
when interact with C3b, liberates Bb which inactivates C3 convertase
11
Q
MCP (protein)
A
