Chapter 3: Respiratory Flashcards

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1
Q

What is Asthma and its pathophysio?

A

Chronic inflammatory disorder characterized by variable airway obstruction with recurrent or chronic wheeze/cough

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2
Q

DDx of wheeze?

A

1) CCF
2) GERD
3) Upper airway obstruction
4) Bronchiectasis
5) COPD

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3
Q

What are the aims of clinical assessment?

A

1) Determine the severity of the attack and rx accordingly
2) Identify pts with high risk of mortality
3) Establish the control of asthma in pt

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4
Q

Hx to ask in asthma attack?

A

1) Symptoms- SOB,wheeze, cough
2) Precipitating factors? Usual triggers?
3) Compliance and control
4) High-risk factors suggestive of decompensation

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5
Q

What to look out for in PE for acute asthma?

A

1) Mentation?(Agitated or drowsy?)
2) Ability to talk in phrases/sentences
3) Level of SOB and exertion
4) Wheeze/Silent chest?
5) Signs of resp distress?
6) RR (Increased or decreased?)
7) HR (120, Severe brady?)
8) Cyanosis?

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6
Q

what are the Risk factors of death from asthma?

A

1) Prior intubation/mech vent for asthma
2) Prior severe sudden exacerbation
3) Prior hosp>1 for asthma in the past 1 year
4) Use of systemic steroids
5) Poor socioeconomic status
6) Psychiatric problems
7) >3 Emed visits for asthma in the past year
8) Use of >2 canisters of B2 agonist inhalers per month

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7
Q

How do you determine asthma control?

A

1) Daytime symptoms
2) Nightime sypmtoms
3) Need for reliever?
4) Functional limitation in daily activities
4) Lung function via PEFR

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8
Q

Are there any invg for asthma?

A

not indicated as dx is purely clinical. H/r there are some special instances where invg can come into use

  • CXR: if pat is not responding to initial therapy to look for alternative ddx such as CCF, pneumothorax etc.
  • ABG: if patient is rapidly deteriorating
  • FBC: to look for infective ppt cause
  • U/E/Cr: to look for hypokalemia due to salbutamol
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9
Q

What is the mgmnt of asthma?

A

1) Supportive measures and ABC.
- monitoring, vital signs, IV access in serious cases
- indications of intubation: severe hypoxia, AMS, persistent hypercarbia, Pa02

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10
Q

Disposition and advice after resolution of asthmatic attack?

A

1) Check inhaler technique
2) Check control of asthma(ACT)
3) Advise pt to avoid ppt factors
4) Emphasize impt of compliance to therapy

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11
Q

What is CAP?

A

-Infiltrates on CXR and Altered breath sounds/local crep in patients who were not hospitalized/residents of long-term facility 14 days before symptom onset

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12
Q

What are common bact pathogens in CAP?

A
  • Strep pneumoniae
  • H. Influenzae
  • Atypicals: Mycoplasma and Legionella
  • Staph aureus
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13
Q

What is the presentation of HIV patients with pulm infection?

A
  • PCP(disproportionate hypoxemia with mild CXR abnormalities)
  • Pulmonary TB
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14
Q

What hx to obtain in pneumonia?

A

1) Presenting Symp
- LRTI(fever, rigours, chills, sweats, new cough+-sputum, chest pain, SOB)
2) PMHX of factors which increase risk of mort
- Old age
- Alcoholism
- Active Malignancy
- Neuro Dz
- CCF
- DM
- Prev pneumonia
3) Prior Rx for current illness eg.prior antibiotics by GP

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15
Q

What to look out for in PE for CAP?

A

1) AMS
2) Signs of resp distress?
3) Signs of shock/dehydration
4) Crepitations
5) RR and HR

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16
Q

What invg to order for in CAP?

A

1) Bloods-FBC, U/E/Cr, Lactate, ABG(in mod-sev CAP), Blood cultures/sputum cultures
2) Radio: CXR
3) Others: CBG, ECG, Urine culture

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17
Q

What is CURB-65?

A

Confusion
Urea>=7
RR>30 breaths/min
BP

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18
Q

What is the mgmnt of CAP?

A

1) Supportive measures-Monitor, vital signs, ABC, fluid resus
2) Anti-microbial therapy
- Hosp but not in ICU: Ceftriaxone +Clarithromycin
- Severe pneumonia: Augmentin +Azithromycin+Ceftazidime

19
Q

What are the types of pneumothorax(PTX)?

A

Primary: No lung pathology that predisposes to PTX
Secondary: Underlying lung is diseased

20
Q

What are the management principles of PTX dependant on?

A

1) Size of the PTX
2) Cinical state of patient
3) The disease state of the underlying lung

21
Q

What is the basis of initial mgmnt of a PTX?

A

1) ABC
2) Administer 100% O2 (the rate of resorption of PTX goes 4X the normal rate to 6% of vol of hemithorax a day if given high flow O2 therapy)

22
Q

What is the invg of choice for PTX?

A

CXR. Use inter-pleural distace (2cm) to determine size and severity of PTX.

23
Q

What is the definitive mgmnt of PTX?

A

If pt is unstable and hypotensive,( BP

24
Q

What is PTX advice?

A

1) No swimming/deep sea diving
2) No mountain climbing
3) No air travel for 6 weeks
4) No other strenuous physical activity for 4 weeks
5) to come back if worsening symp

25
Q

What is the relation between DVT and PE?

A

Leg DVT is found in 70% of pts with PE and 50% of those with DVT get PE. However PE is less likely if DVt is confined to calf veins

26
Q

What is Virchow’s triad and what are the RFs of PE?

A

1) Venous Stasis
- Prolonged immobility(recent travel), major surgery/trauma, advanced age, obesity
2) Endothelial damage-major surgery to legs/pelvis, thrombophlebitis, local trauma to legs
3) Hypercoagulability-Protein C/S def, Factor V Leiden mutation, APS, Anti-thrombin III def, OCP, Polycythemia, malignancy

27
Q

What clinical features are expected in PE?

A

Triad of:
Chest pain(pleuritic)
Tachypnoea(>20 breaths/min)
SOB

Hypercapnia is rare in PE but hypoxemia is a classical feature.
Orthopnea does not occur

28
Q

How does one classify patients based on pre-test probability of having PE?

A

If pt has classical triad of symptoms not explained by any other cause AND

1) radiographic signs of PE(Hampton’s hump and Fleischner sign)
2) High-risk factors based on Virchow triad
3) Signs of leg DVT(erythema, pain, swelling)
4) ECG signs of R heart strain and fainting

29
Q

What is the initial mgmnt of PE?

A

1) ABC and monitor vitals in P1 area
2) Give O2 via NRM but if indicated may need to intubate(however, know that intubation may further exacerbate the hypotension)
3) 2 large bore IV cannula and start fluid resus(if BP low, can start inotropes)
4) Give pain relief
5) Contact CTVS

30
Q

What invg do you order for PE?

A

1) Bloods
- FBC
- U/E/Cr
- ABG(reduced PaO2)
- D-Dimer ELISA test (if pre-test prob is low and D-dimer -ve can exclude PE but high pre-test prob and -ve D-dimer does not help)
- GXM 4-6 units
2) Radio
- CXR(Normal in 40%) Other findings are Hampton’s hump, Fleischner sign, Westermark sign, small pleural effusions)
- CTPA(Primary radio scan offered to evaluate PE and can help to look for ddx as well)
- Bedside U/S (look for R heart dilatation/reduced function)
3) Others
- ECG(most common is T wave inversion in anteroseptal and inf leads, S1Q3T3, R heart strain)

31
Q

What is the definitive mgmnt for PE?

A

If small PE: IV heparin 5000 U bolus/SC fraxiparine

If unstable PE: Urgent embolectomy/catheter directed thrombolysis

32
Q

What are the key features of making a dx of COPD?

A

1) Chronic cough
2) Chronic sputum production
3) SOB esp during exertion and infections
4) Exposure to smoke/occupational dusts etc.

33
Q

What is the GOLD Classification?

A

0: At risk (normal spirometry and chronic symptoms)
I: Mild (FEV1>80)
II: Mod(50

34
Q

How do you differentiate between asthma and COPD?

A

Asthma when there is complete broncho reversibility with bronchodilators and diurnal variation in peak flow of >20%

35
Q

History to ask in COPD?

A
  • Presenting symptoms: increased SOB, Cough, Purulent sputum from baseline, fever
  • PMHx: Prev intubations, prev NIV, no. of hosp/ED visits
  • Current meds and compliance
36
Q

What invg do you do for COPD?

A

Like asthma mostly clinical but invg can be used as adjuncts to guide/monitor response of mgmnt strategies

  • Bloods: FBC(look for leukocytosis), U/E/Cr if pt is septic and dehydrated, ABG(after 2 nebulizations in order to determine need for NIV)
  • Radio: CXR (Look for cause(pneumonia) or Cx(PTX)
  • Others: ECG(may see right heart strain, p pulmonale, MAT)
37
Q

What is the supportive mgmnt in COPD?

A
  • They should be placed in a monitored area with vitals signs.
  • ABC:
  • Airway secured via the necessary means: NIV/Intubation
  • Ventilatory settings should be low rate, low tidal volume and prolonged exp phase
  • Fluid resus should be judicious considering the fact that there is significant R heart issues in chronic COPD
38
Q

What is the definitive mgmnt in COPD?

A

Drug therapy:

  • Bronchodilators: B agonist(Salbutamol nebulized with ipratropium every 20mins for 1hr)
  • Steroids(Prednisolone PO 0.5-1mg/kg)
  • Antibiotics if there are signs of LRTI causing exacerbation of COPD: Augmentin/Azithromycin
39
Q

What advice do you give COPD patients on discharge?

A

1) Flu vaccination (age>65)
2) Stop smoking
3) Inhaler technique and importance of compliance

40
Q

What are the ddx of stridor in a child?

A
  • Epiglottitis
  • Croup
  • Foreign body aspiration
  • Angioedema
  • Retropharyngeal/peritonsillar abscess
  • Smoke inhalation
41
Q

What is the general supportive mgmnt of stridor?

A

1) Monitor at critical resus area with continuous vital signs monitoring
2) Airway management equipment ready with cricothyrotomy set
3) Administer supp O2 to maintain SpO2>95%
4) Establish peripheral IV line and resus drugs available with senior docs from both ENT and Anaesthesia ready

42
Q

What is the mgmnt of epiglottitis?

A

1) ABC
2) Provide humidified O2
3) Airway maintenance with definitive surgical airway/intubation before further dx evaluation is done
4) Administration of antibiotics
- IV Ceftriaxone 2g or 100mg/kg and Clindamycin 600mg
5) Lateral neck X-ray if need be to see thumb sign

43
Q

What is the mgmnt of FB aspiration?

A

1) Series of 5 back blows and 5 chest thrusts in age 1
2) Direct inspection of hypopharynx via laryngoscope. Remove the FB with Magill Forceps if it’s accessible
3) If unsuccessful and pt deteriorating, perform intubation/surgical airway
4) Specialist team perform bronchoscopy or laryngoscopy.

44
Q

What are the impt invg to do in a typical case of SOB?

A
Bloods:
-FBC(Hb, WBC)
-U/E/Cr
-ABG(look for resp failure and cause)
-CBG (metab acidosis) 
Radiology:
-CXR
Others: 
-ECG(in elderly esp)
-+Drug screen