Chapter 3: Biological Psychology Flashcards
What are:
Neurons?
Dendrites?
Axon?
Axon terminals?
- Neuron: Nerve cells specialized for communication with each other.
- Dendrite: Neurons contain multiple branchlike extensions for receiving info from other neurons.
- Axon: Like transmitters, specialized for sending messages to other neurons.
- Synaptic vesicles travel the axon to reach the axon terminal; It bursts & releases neurotransmitters.
What is synapses?
- Once released from synaptic vesicle, neurotransmitters enter synapse (fluid-filled space).
- Synapse consists of synaptic cleft (gap in which neurotransmitters are released from axon terminal).
- As neurotransmitters are released from axon into synapse, they’re quickly received by receptors on dendrites.
What are the 2 types of glial cells? Explain their functions are where they are plentiful:
- Astrocytes:
- Communicate with neurons, control blood flow in brain, play role in development of embryo.
- Involved in memory, thought, & immune system.
- Astrocytes are found in the blood-brain barrier: protective shield.
- Oligodendrocytes:
- Promote new neural connections, aid in healing.
- Produces myelin sheath (insulator wrapper around axon).
- Glial cells also clear away debris (cellular garbage disposal).
- Treatment that targets glial cells may one day assist in controlling pain & treating conditions related to number of activity of these cells.
What is resting potential? (Depolarization)
- Potential to fire.
- When there is no neurotransmitters acting on neuron, membrane is at resting potential. (more neg particles inside than outside neuron, which produces a polarized state.)
- Voltage: -70mV.
- Particles flow in & out of membrane while at rest.
- When electrical charge inside reaches a high enough threshold (-55mV), electrical impulse called action potential is triggered.
What is action potential? (Polarization) What is the all-or-none law?
- For a neuron to fire, its must receive a certain amount of stimuli (channels open, & +ions flow into neuron) in order to start process.
- As soon as action potential has passed, neuron returns to resting state. + ions flow back across membrane, & restore polarity; triggers release of neurotransmitters.
- All-or-none law: Once a neuron fires, it cannot be stopped or reversed.
What is the refractory period?
- Each action potential is followed by a refractory period, a brief interval during which another action potential cannot occur.
- Limits maximal firing rate.
What are graded potentials?
- Different from action potential.
- Postsynaptic potentials that can be excitatory or inhibitory depending on whether + or - charged particles flow across neuronal membrane, & in which direction they flow.
- If binded appropriately, receptors open, which can cause an excitatory postsynaptic potential (EPSP) if ions are allowed in. This depolarizes neuron.
- If - charged ions move in, it will cause inhibitory postsynaptic potentials (IPSP).
- This hyperpolarizes neuron. Graded potentials of same time are added tog., while potentials of diff. types cancel out (e.g. EPSP & IPSP).
- Graded potentials can increase or decrease likelihood that an action potential will occur.
What are neurotransmitters?
- Chemical messengers.
- Some excite nervous system, increasing activity, & some inhibit nervous system, decreasing activity.
What happens after neurotransmitters are released into the synapse?
- They bind to receptor sites along dendrites of neurons.
- Receptor sites: Specialized to receive only certain types of neurotransmitters.
What is glutamate & GABA?
Glutamate: Excitatory.
- Enhanced learning & memory.
- Elevated: schizophrenia (high dose=toxic).
GABA: Inhibitory
- Plays roles in learning, memory, & sleep.
- Anti-anxiety meds bind to GABA receptors, tend to suppress overactive brain areas.
-Drugs that target GABA receptors could treat anxiety, insomnia, depression, & epilepsy one day.
What is Acetylcholine?
Acetylcholine:
- Arousal, sleep, selective attention, & memory.
- In Alzheimer’s, neurons containing acetylcholine are destroyed, leading to memory loss. Meds that alleviate memory-related symptoms boost acetylcholine in brain.
- Neurons that connect directly to muscle cells also release acetylcholine, allowing them to trigger movement.
- This is how insecticides work.
What is Monoamines?
-Norepinephrine, dopamine, & serotonin.
Dopamine:
-Rewarding experiences.
Norepinephrine & Serotonin:
- Activate or deactivate parts of brain.
- Arousal, readiness to respond to stimuli.
What is Anandamide?
Marijuanas THC:
- Cells make anandamide, which binds to same receptors as THC.
- Eating, motivation, memory, & sleep.
What are Neuropeptides?
Neuropeptides:
- Short strings of amino acids.
- Act like neurotransmitters.
Endorphins: (type) (naturally occurring opioids)
- Pain reduction.
- Morphine exerts its effects by hijacking endorphin system, binding to endorphin receptors & mimicking their effects.
-Other neuropeptides regulate hunger, & satiety, learning & memory.
What are psychoactive drugs?
How do opioids, tranquilizers, & antidepressants interact with neurotransmitter systems?
- Drugs that interact with neurotransmitter systems. They affect mode, arousal, or behaviour.
- Targets production or inhibition of certain neurotransmitters.
Opiates: (codeine or morphine)
- Increase receptor site activity.
- Reduce emotional response to painful stimuli by binding with opioid receptors, & mimicking endorphins.
Tranquilizers: (Xanax)
-Diminish anxiety by stimulating GABA receptor sites, driving down neuronal activity.
Anitdepressants: (Prozac & Paxil)
-Inhibit reuptake of certain neurotransmitters to remain in synapse longer than usual.
What does it mean if drugs functions as receptor antagonists?
- Decrease receptor site activity.
- Act as fake neurotransmitters, fooling receptors into thinking they are dopamine without exerting the effects.
How do medications that treat schizophrenia work?
- They block dopamine receptors by binding to them, thereby blocking dopamine from binding to the receptors themselves.
- (drugs like cocaine=excitatory=dopamine)
What is neural plasticity?
- Plasticity: Describes nervous system’s ability to change.
- Nervous system often can’t change enough to compensate for injury or stroke, which leads to permanent paralysis & disability.
- Brain most capable of of change during early development, but our brains are capable of plasticity even in our late years.
-Crucial for learning.
What are the 4 primary ways in which the network of neurons in the brain change overtime?
- Growth of dendrites & axons.
- Synaptogenesis: formation of new synapses
- Pruning: consisting of the death of certain neurons & restrictions of axons to remove connections that aren’t useful. (less is more)
- Myelination: Insulation of axons.
How does synaptogenesis occur?
-Our brains change as we learn, & these changes can result from synaptogenesis, generating increased connections & communication among neurons.
What is potentiation?
- Our brains change as we learn.
- This can result from the strengthening of existing synaptic connections, so that the neurotransmitters released into synapses produce stronger & more prolonged responses from neighbouring neurons.
- When it is enduring, its called long-term potentiation (LTP).
Does the brain & spinal cord possess the ability to regenerate followed by an injury or serious illness?
Can certain brain regions take over the functions previously preformed by others?
- Not really. They possess limited regeneration.
- Sometimes.
What is neurogenesis?
-Creation of new neurons in adult life. (occurs in monkeys, and maybe humans)
What are the functions of stem cells? What is gene therapy?
- Have potential to become a wide variety of specialized cells.
- Offer several ways of treating diseases marked by neural degeneration.
- Researchers can genetically engineer stem cells to provide gene therapy: provide patient with replacement genes.
- However, stem cell research is controversial. (could cure Alzheimer’s, diabetes, cancers, but its unethical as stem cells are early forms of human life.)
Which 2 systems are apart of the PNS?
The CNS is composed of: (2)
Somatic nervous system:
-Control voluntary behaviour.
Autonomic nervous system:
-Control involuntary functions of body.
-CNS: Brain & spinal cord.
What the the (6) distinct sections/ systems of the CNS?
- Cortex
- Basal Ganglia
- Limbic System
- Limbic System
- Cerebellum
- Spinal Cord
What are the (4) lobes of the Cortex (outermost part of cerebrum) & their functions?
- Frontal lobe.
- Temporal Lobe.
- Parietal lobe.
- Occipital lobe.
What is the Basal Ganglia’s function?
-Control movement & motor planning.