Chapter 3 Flashcards
what percent of the body weight in adults is water
58-60%
the non cellular portion of the blood is known as
plasma
the plasma communicates continually with the intestitial fluid by
capillary pores
how many proteins are in the plasma
about 200
the plasma constitutes about ___% of the bdoy weight
5
the total body volume of water is about
41-42L
drug ______ means the reversible transfer of drug from one location to another within the body
distribution
distribution is the processs by which an absorbed drug moves
away from the site of absorption to other areas of the body where it had no drug initially
what is the concentration gradient of drug distribution
in the direction of plasma to tissues
what does the pattern of distribution reveal
the nature of the drug
ease of penetration through different membranes
what are the patterns of distribution?
largely confined to vascular systems
throughout the bod water
concentrated specifically in one more tissues which ay or may not be their site of action
non uniform distributionw
which pattern of distribution is seen in most drugs
non uniform
the variations in distribution noted in most drugs is largely determined by
the ability of drugs to pass through membranes and their lipid water solubility
chlorpromazine is concentrated specifically in
uveal tract of eye
griseofulvin is primarily concentrated iin teh
skin and nails
tetracycline is primarily concentrated in
THE BONE, IRREVERSIBLY
iodine is primarily concentrated in the
thyroid gland
chloroquine is concentrated in the
liver more than plasma
Vd us the volume of fluid in which
the drug appears to be distributed
THEORETIC
what factor must be taken into account when estimating the amount of drug in the body
the volume of sampled fluid needed
what is the volume of plasma in the blood
3-4 L
pattern 2 produces V value of
30-50L total body water
pattern 3 is large V values whichis
6500L
patten 4 may have V values of
wide range values
drugs with a small or negative log P value are
hydrophillic
hydrophilic drusgs have a Vd close to 41L
pattern 2
