Chapter 3 Flashcards
Varicocele
Where the enlarged veins on male testicles raise the temperature in the testes interfering with sperm production
What increases success rates of IVF?
Selecting optimal eggs based on mitochondria, changing the time when eggs are harvested for fertilisation and augmenting egg cells in a bath of mitochondria
What are the three periods of prenatal development?
- Germinal period (first 2 weeks)
- Embryonic period (3-8 weeks)
- Fetal period (9 week till birth)
What happens in the Germinal Period?
In the first week or two, the zygote divides through mitosis to form a blastocyst. At day 6, it implants in the uterine wall. During this period, many may miscarry.
What happens during the embryonic period?
Organogenesis (formation of organs) occurs. The outer layer of the blastocyst becomes the amnion and chorion (later placenta). The interior gives rise to the ectoderm, mesoderm and endoderm which later forms tissues/organs. At 3-4 weeks, the neural plate folds to become the neural tube. Sex differentiaion occurs in the last week
What are the consequences of a improperly formed neural tube?
- Spina Bifida (where a part of the spinal cord is not fully encased in a protective covering of the spinal column)
- Anencephaly (main portion of the brain above the brain stem fails to develop)
What occurs in the fetal period?
3 steps in brain development: Proliferation - neurons multiply at a staggering rate to form around 100 billion neurons. After birth, proliferation produces an increase in glial cells. Migration - neurons move to particular locations where they become specialised. Differentiation occurs last where neurons specialise.
What is the environment of an unborn child?
The prenatal environment
What is the social environment for a child?
All the people who can influence and be influenced by the developing person and the broader culture
What were the misconceptions about the placenta?
While it was thought that the placenta served as a screen to protect the fetus from harmful substances, it is not the case. Epigenetic effects are most shown during the prenatal period
What are “reciprocal influences”?
The idea that people shape their physical and social environments and are affected by the environments they helped create.
What impacts developmental outcomes?
Fetal programming brought about by epigenetic effects of the environement. Therefore, prenatal experience can change a person’s physiology and wiring of the brain.
Who may also be affected by prenatal environmental factors?
The offspring of the unborn child may also be affected. Therefore a woman’s grandchildren may also be affected by health, diet and environment
How do teratogens effect development?
- Critical period - the effects of tertogens are worst during the critical period when an organ system grows rapidly
- Dosage and duration - the greater and longer level of exposur, the more damage
- Genetic makeup - susceptibility to harm is influenced by the genetic makeup of the unborn child and the mom.
- Environment - its effect depends on the quality of the prenatal and postnatal environements
What was the effect of thalidomide?
It was a mild tranquilizer used to relieve morning sickness - caused many women in the 1950s to give birth to babies with missing limbs, deformed eyes/hearts etc.
What is the effect of tobacco?
Smoking can lead to miscarriage, prematurity, respiratory problems, cleft lip etc. It is also significant to sudden infant death syndrome (SIDS). Smoking restricts blood flow to the fetus which may lead to these effects.
What is the effect of alcohol?
Alcohol readily crosses the placenta which impacts the process of neural migration, neuronal death and impaired glial cells. Worst is fetal alcohol syndrome (FAS). FAS usually lead to certain facial characteristics and smaller bodies and they often exhibit hyperactive behaviour and low IQ. There is also a spectrum disorder for this. There is no critical period - any drink any time is bad.
Teratogens and fetal development period
Teratogens affect certain parts of the body depending on what development occurs in each. For example, in the embryonic stage, teratogens often affect neurons.
What are factors that effect the damage of teratogens?
- The mother’s physiology (such as metabolism of alcohol) and mental status
- The embryo’s genetic makeup and physical condition affect their resistance and recovery from damage.
What is the effect of illicit drugs?
An example is cocaine and opiods. Cocaine reality crosses the placenta and constricts blood vessels, leading to miscarriage, premature detachment of the placenta or later fetal stroke. It also leads to malnourishment, restricted growth etc, also impacting the growth of the amygdala. Babies from opiods are often smaller, need respritory and a c-section as well as are at risk of neonatal abstinence syndrome (NAS)