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Endocrinology > Chapter 3 > Flashcards

Chapter 3 Flashcards

1
Q

peptide general structure

A

amino acid chains

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2
Q

catecholamine general structure

A

tyrosine derivative

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3
Q

thyroid general structure

A

iodinated tyrosine derivative

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4
Q

steroid general structure

A

cholesterol derivative

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5
Q

peptide solubility

A

water-soluble

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6
Q

catecholamine solubility

A

water-soluble

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7
Q

thyroid solubility

A

lipid-soluble

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8
Q

steroid solubility

A

lipid-soluble

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9
Q

peptide transport in blood

A

dissolved in plasma

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10
Q

catecholamine transport in blood

A

dissolved in plasma or bound to carrier proteins

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11
Q

thyroid transport in blood

A

bound to carrier proteins

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12
Q

steroid transport in blood

A

bound to carrier proteins

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13
Q

peptide location of receptor

A

usually cell membrane

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14
Q

catecholamine location of receptor

A

cell membrane

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15
Q

thryroid location of receptor

A

intracellular

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16
Q

steroid location of receptor

A

intracellular

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17
Q

peptide general target response

A

modification of existing proteins

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18
Q

catecholamine general target response

A

modification of existing proteins

19
Q

thyroid general target response

A

induction of new protein synthesis

20
Q

steroid general target response

A

induction of new protein synthesis

21
Q

peptide half life

A

short

22
Q

catecholamine half life

A

short or long depending on if its bound to carrier protein or not

23
Q

thyroid hormone half life

A

long

24
Q

steroid half life

A

long

25
Q

peptide degradation/ metabolism

A

degraded by proteases; receptor-mediated endocytosis

26
Q

catecholamine degradation/ metabolism

A

inactivated by COMT, MAO; receptor-mediated endocytosis

27
Q

thyroid degradation/ metabolism

A

deiodinases

28
Q

steroid degradation/ metabolism

A

conjugation; inactive form

29
Q

peptide location of synthesis

A

RER and Golgi of several endocrine organs

30
Q

catecholamine location of synthesis

A

cytoplasm of chromaffin cells in adrenal medulla

31
Q

thyroid location of synthesis

A

thyroid colloid of follicular cells

32
Q

steroid location of synthesis

A

cytoplasm and mitochondria of adrenal cortex, placenta, gonads

33
Q

peptide production time

A

made in advance

34
Q

catecholamine production time

A

made in advance

35
Q

thyroid production time

A

made in advance

36
Q

steroid production time

A

made on demand

37
Q

peptide storage

A

stored in endocrine organs

38
Q

catecholamine storage

A

stored in chromaffin cells

39
Q

thyroid storage

A

stored in secretory vesicles

40
Q

steroid storage

A

not stored (precursor cholesterol is stored)

41
Q

peptide release

A

exocytosis

42
Q

catecholamine release

A

exocytosis

43
Q

thyroid release

A

simple diffusion

44
Q

steroid release

A

simple diffusion

Endocrinology (3 decks)

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