Chapter 3 Flashcards
Compare the attachment and phagocytization of discs in the rods and cones.
Rods- discs are free floating, phagocytize during the day
Cones- are fixed, phagocytize during the night
Where in the retina/brain do we have divergence of information?
From V1 (striate cortex)
Describe the flow from optic nerve to tract to optic radiations. Where is there feedback?
LGN (synapse) to cerebral cortex into striate visual cortex AND extrastriate visual cortex separated by corpus callosum then to higher cortical areas (integration)
Feedback from higher cortical areas to V1 and LGN
What is the range of light levels over which the visual system can function? What determines this range?
About 10 log units
Rods (scotopic) and Cones (photopic) (Duplex Retina)
Pupils account for about 1 log unit
Describe mesopic function.
Twilight
Area where both rod and cones are operating
Moonlit/Starlit paper
When do we have optimal acuity?
When the rods are saturated
Describe the properties of scotopic vision.
– Rod mediated
– Operates under nighttime lighting conditions
– High absolute sensitivity to dim light (only 10 quantal absorptions required)
– Poor contrast sensitivity
– Poor visual acuity (~20/200)
– Colorblind
Describe the properties of photopic vision.
– Cone mediated
– Operates under daytime lighting conditions
– Poor absolute sensitivity to dim light
– High contrast sensitivity
– Good visual acuity (~20/20)
– Color vision
What is the blind spot?
No PR in optic disc
15 degrees temporal to fixation
What is retinitis pigmentosa?
Family of diseases causing damage to rods and cones
Can cause blindness
Allows waste to build up if phagocytization cannot occur
Scotopic usually affected first
Describe retinal prostheses and how it can treat damaged retinal tissue.
Camera in spectacle sends image to microelectrode array on RNFL, or at site of retinal damage
Electrodes stimulate gc axons (bipolar cells) mimicking undamaged PR stimulation of GC
What occurs to the photoreceptors when it’s pigment absorbs a light quanta?
Hyperpolarizes
How much light can each molecule of rhodopsin absorb? How many quanta does it take to activate a rod?
One
One
Eye has a lot of rhodopsin (sensitivity)
What does a molecule of rhodopsin become bleached? What is the max it can absorb, what happens after? How does it become unbleached?
When it absorbs light (one quantum of light)
Anything after one quantum is transmitted as a function of wavelength
Spontaneously (half life of 5 minutes)
What is the reciprocal of the transmission curve?
Absorption
According to the absorption curve, when is a molecule of rhodopsin MOST likely to be absorbed?
When is a molecule most likely to be transmitted?
At 507nm
At 500nm
Define univariance.
Once rhodopsin absorbs light all information about the quantum of light is gone
Effects of the different wavelengths are now the same
(Wavelength affects probability of absorption
Why does the scotopic spectral sensitivity function have the same shape as the absorption function?
The human scotopic sensitivity function is determined by absorption characteristics of rhodopsin.
What percentage of quanta incident on the retina are actually absorbed?
20% b/c most is reflected or absorbed by other tissue
Is sensitivity the reciprocal of threshold?
Yes
As threshold increases what happens to sensitivity?
Decreases
How is the scotopic spectral sensitivity function measured? Define threshold.
Patient sits in totally dark room to allow rhodopsin to regenerate
We flash a stimulus to determine the sensitivity
The minimum amount of energy needed to detect stimuli is threshold
What are the 3 classes of cones?
L-cones: contain erythrolabe (red, long, peak @426nm)
M-cones: contain chlorolabe (green, middle, peak @530nm)
S-cones: contain cyanolabe (blue, short peak @557nm)
Which cones contribute to the photopic spectral sensitivity function? Where does it peak? How is it performed?
L and M
Peak @555nm
Measured under brighter lighting conditions
How does the regeneration of cone pigments after bleaching compare to rhodopsin?
Half life of 1.5 minutes for 50% recovery
Faster than rhodopsin
What is the Purkinje Shift?
The relative increase in the brightness of longer wavelengths stimuli as lighting condition change from scotopic to photopic
Wavelength to which we are most sensitive changes from 507nm to 550nm