Chapter 28: Anti-infective and Antihistamine

Question 1

Signs of infection

Answer 1

• Fever
• Sweats
• Redness
• Swelling
• Weight loss
• Low WBC
  -Pus

Question 2

Infectious prevention measure

Answer 2

• Hand washing
• Disinfectant: kills bacteria
• Antiseptic: inhibits growth

Question 3

Common classes of antibiotics

Answer 3

Sulfonamides
Penicillin
Cephalosporin
Macrolides
Quinolones
Aminoglycosides
Tetracyclines

Question 4

Common MOA of Antibiotics

Answer 4

``11. Interfere with
- Cell wall synthesis
- Protein synthesis
- Dna replication
-Acts as metabolite to disrupt metabolic reactions inside the cell

Question 5

Sulfonamides

Answer 5

-one of first groups of antibiotics

Commonly used in clinical practice
Bactrim: sulfamethoxazole & trimethoprim
Septra
SMX-TMP

Question 6

Sulfonamides MOA

Answer 6

Do not destroy or kill bacteria but rather inhibit their growth
- By preventing bacterial synthesis of folic acid
- Bacteriostatic antibiotic & Antimetabolites
-

Question 7

Sulfonamide Indication

Answer 7

-Treatment of UTIs
- Respiratory tract infections
- Prophylaxis treatment is patients with immuno deficiency virus HIV
-Effective against gram-positive and gram-negative bacteria

Question 8

Sulfonamides Adverse effect

Answer 8

Blood: Hemolytic abd aplastic anemis , thrombocytopemia
Integumentary: Photosensitivity, exfoliate, streven Johnson syndrome
GI: nausea, vomtiting , diarrhea
Others: Hepatoxicity, convulsions, toxic nephrosis