Chapter 22

Question 1

Base Promoted Amide Hydrolysis

Answer 1

turns amide into carb acid and salt

Question 2

Reactivity series

Answer 2

aminde, ester and carb acid, anhydride, acid halide increasing reactivity
-anything can be converted to something to its left

Question 3

addition-elimination mechanisms

Answer 3

-rxn goes to the right if LG is more stable than Nu

Question 4

Reaction of Ester with OH (saponification)

Answer 4

-acid/base rxn is driving force
-ester turns into carboxylate ion and oh-r if only OH
-If HCL turns into carb acid and OH-r

Question 5

Haloform RXN

Answer 5

reagent: I2, Br2, Cl2
-Happens when alpha-c is CH3
-makes a carb acid and HCx3

Question 5

Soap Chemistry

Answer 5

Triglyceride turns into glycerol and soap molecules

Question 5

Ester Reduction

Answer 5

-LAH reagent
-reduces ester to an OH

Question 5

Hydride Reductions

Answer 5

-LiAlH4-can reduce everything
-NaBH4 cant reduce all but carb acid, amide, nitrile, esters

Question 6

Acid Halide Reduction

Answer 6

-LAH or NaBH4 both reduce it to an alcohol

Question 7

Carb Acid reduction

Answer 7

-LAH
-turns into an alcohol

Question 8

Amide Reduction

Answer 8

-LAH only
-turns amide into just NH not c=o bond

Question 9

Partial Ester Reduction with DiBAL-H

Answer 9

-reagent DiBAL-h, low temp
-reduced ester to an aldehyde

Question 10

Organometallic Addition

Answer 10

reagent: r-MgBR and H3o
R’ adds two times and turns c=o to oh

Question 11

R-OH

Question 12

Organocuprate Coupling

Answer 12

reagent: RCuLi
-leaving group gets replaced with R only once