Chapter 20: The Cardiovascular System: The Heart Flashcards
Where is the heart located?
It lies in the mediastinum, the anatomical region that extends from the sternum to the vertebral column, from the 1st rib to the diaphragm
It rests on the diaphragm near the midline of the thoracic cavity
Describe the apex and base of the heart
Apex is pointed and formed by the tip of the left ventricle
the base is its posterior aspect formed by the atria (upper chamber), mostly the left atrium
Describe the anterior and inferior surface of the heart
Anterior - deep to the sternum and ribs
Inferior - part of the heart between the apex and right surface and rests mostly on the diaphragm
Differentiate between the right and left surfaces of the heart
Right - faces right lung and enters from inferior surface to base
Left - face left lung and extends from base to apex
Define the pericardium and its 2 main parts
pericardium - membrane that surrounds and protects the heart
- Fibrous pericardium - tough, inelastic, dense irregular connective tissue that prevents overstitching, provides protections, and anchors the heart in the mediastinum
- Serous pericardium - deeper, thinner, delicate membrane that forms a double layer around the heart; outer parietal layer is fused to the fibrous pericardium and inner visceral layer aka epicardium adheres tightly to the heart
Define pericardial fluid
Thin film of lubriccating serous fluid between the parietal and visceral layers of the serous pericardium
It reduces friction as the heart moves and is located in the pericardial cavity
Describe the 3 layers of the heart wall
- Epicardium (external layer) is composed of 2 tissue layers: outermost is the visceral layers of the serous pericardium composed of mesothelium; beneath is a variable layer of delicate fibroeslastic tissue and adipose tissue, thickest over ventricular surfaces
- Myocardium (middle) is responsible for the pumping action of the heart and is composed of cardiac muscle tissue and the fibers are composed of endomysium and perimysium and organized in bundles that swirl diagonally around the heart
- Endocardium (inner) is a thin layer of endothelium overlying a thin layer of connective tissue that provides a smooth lining for the chambers of the heart to minimize surface friction and covers the heart valves
List the 4 chambers of the heart
The two superior receiving chambers are the atria and the two inferior pumping chambers are the ventricle
Define the auricle
A wrinkled pouch like structure on the anterior surface of each atrium that slightly increases the capacity of an atrium so that it can hold a greater volume of blood
What is the significance of a sulcus?
Each sulcus marks the external boundary between two chambers of the heard - they are a series of grooves that contain coronary blood vessels and fat
Coronary vs anterior interventricular sulcus vs posterior interventricular sulcus
Coronary - encircles most of the heart and marks the external boundary between the superior atria and inferior ventricles
anterior - shallow groove on the antihero surface that marks the external boundary between the right and left ventricles on the anterior aspect of the heart
posterior - marks external boundary between the ventricles on the posterior aspect of the heart
The right atrium receives blood from which 3 veins?
superiro vena cava, inferior vena cava, and coronary sinus
Describe the following aspects of the right atrium: pectinate muscles, interatrial septum, fossa ovals, tricuspid valve
The anterior wall fo the atrium is rough due to pectinate muscles which are muscular ridges that extend into the auricle
Interatrial septum - a thin portion between the right and left atrium
Fossa ovalis - a oval depression in the septum, which is a remanent of the foramen oval, an opening in the septum that closes soon after birth
tricuspid valve - blood passes from the right atrium to the right ventricle through this valve that consists of 3 cusps
Describe the following components of the right ventricle: trabecular carneae, chordae tendineae, papillary muscles, inter-ventricular septum, pulmonary valve
Trabecular carneae - cardiac muscle fibers that form a series of ridges inside the ventricle
Chordae tendineae - cords connected to the tricuspid valve which are intern connected to a cone-shaped trabeculae cornea called papillary muscles
Interventricular septum - suppurates the right and left ventricle
Pulmonary valve - blood passes from right valve into a large artery called the pulmonary trunk which divides into the right and left pulmonary arteries and caries blood to the lungs
How does blood flow in and out of the left atrium?
Received blood from the lungs via the pulmonary veins and passes into the left ventricle via the bicuspid (mitral) valve
Describe the left ventricle and its following components: aortic valve, ligaments arteriorsum
The left ventricle is the thickest chamber and forms the apex of the heart
Blood passes from the left ventricle through the aortic valve into the ascending aorta - some flow into coronary arteries and the remained passes into the arch of the aorta and descending aorta where it is carried throughout the body
Ligamentum arteriosum - connects the arch of the aorta and pulmonary trunk and is the remanent of the ductus arteriosus that closes shortly after birth
How does myocardial thickness relate to its function?
Ventricles pump blood under higher pressure and thus are thicker
Additionally, the left has a much larger workload as it must pump blood throughout the body and thus is thicker than the right
What is the fibrous skeleton of the heart?
The fibrous skeletal consists of four dense connective tissue rings that surround the valves of heart, fuse with one another, and merge with the interventricular septum
This is in addition to cardiac muscle tissue and prevents overstitching of the valves and serves asa point of insertion for bundles of cardia muscle fibers
Describe the operation of the atrioventricular valves (AV)
The AV include the tricupsid and bicuspid valve
When ventricles are relaxes, papillary muscles are relaxed, chordae tendineae are slack, and blood moves from a higher pressure in the atria to a lower pressure in the ventricles through open AV valves
When ventricles contract, the blood drives the cusps upward until their edges meet and close the opening
If AV valves or chordae tendinaea are damaged, blood may regurgitate (flow back( into the atria when ventricles contract
Describe the operations of the semilunar valves (SV)
SV are in both the aortic and pulmonary valves because they are made up of 3 crescent moon-shaped cusps
Each cusp attaches to the arterial wall by its convex outer margin and they allow ejection of blood from heart into arteries but prevent bacflow into the ventricles
When ventricles contract, pressure builds up and the SL valves open when pressure in the ventricles exceeds pressure in the arteries, permitting ejection of blood from the ventricles into the pulmonary trunk and aorta
What is the difference between systemic and pulmonary circulations?
The left side of the heart is the pump for systemic circulation - it receives red oxygenated blood from the lungs and the ventricle elects blood into aorta and carries it throughout the body here it looses O2 and gains CO2
The right side of the heart is the pump for pulmonary circulation - it receives all of the dark-red deoxygenated blood returning and the blood is ejected from the right ventricle into the pulmonary arteries were it is is taken to the lungs to be exhaled and picks up O2
Describe the major features of coronary circulation
Coronary circulation - myocardium’s own network of blood vessels as nutrients cannot diffuse quickly enough from blood
Coronary arteries branch from the ascending aorta and encircle the heart and while the heart is contracting there is little blood flow when when the heart contracts the high pressure in the aorta propels through the arteries into the coronary veins
Define collateral circulation
Anastomoses are are where blood from branches of more than one artery that supply the same region connect
They provide alternate routes known as collateral circulation for blood to reach a particular organ or tissue
The myocardium as many anastomoses that provide detours for arterial blood if a main route becomes obstructed
The left and right corral arteries deliver blood to the heart. How do they branch out?
Left -> circumflex branch & anterior interventricular branch
Right -> marginal branch & posterior interventricular branch
What are the 4 principal tributaries caring blood into the coronary sinus?
Great cardiac vein
Middle cardiac vein
Small cardiac vein
Anterior cardiac vein
Describe the general histology of cardiac muscle fibers
- They are shorter and less circular than skeletal muscles
- They have branching which gives a staircase appearance
- One centrally located nucleus (sometimes 2)
- Ends of cardiac fibers are connected to one another by thickenings called intercalated discs
- Have larger and more numerous mitochondria
Describe desmosomes and gap junctions within cardiac muscle fibre
Within intercalated discs are desmosomes and gap junctions
Desmosomes hold fibers together and gap junctions allow muscle APs to conduct from one muscle fibre to another
Describe autorhymitc fibers and their 2 main functions
They repeatedly generate APs that trigger heart contractions and have 2 important functions:
- act as a pacemaker - setting the rhythm of electrical excitation that causes contraction
- from the cardiac conduction system, a network of specialized cardiac muscle fibers that provide a path for each cycle of cardiac excitation to progress through the heart
Describe the 5 steps of the cardiac conduciton system
- Excitation begins in the sinoatrial (SA) node located in the right atrial wall, which repeatedly depolarize to threshold spontaneously, termed the pacemaker potential. When threshold it reached an AP propagates via gap junctions causing the two atria to contract simultaneously
- AP reached the atrioventricular (AV) node, located in the interatrial septum, where it slows allowing time for the atria to empty their blood into the ventricles
- AP then enters the atrioventricular (AV) bundle - the only place where APs can conduct from atria to ventricles
- AP enters right and left bundle branches that extend through the interventricular septum towards apex
- Purkinje fibers rapidly conduct the PA at the apex upward to the remainder of the ventricular myocardium, causing ventricular contraction pushing blood toward SV
What is an artificial pacemaker useful for?
When the SA node becomes damage or diseases an artificial pacemaker can send out small electrical currents to stimulate the heart to contract
What are the 3 steps of an action potential in a ventricular contractile giber?
- Depolarization - resting potential is close to -90mV and when it is brought to threshold its fast voltage gated Na+ channels open, causing rapid influx producing a rapid depolarization
- Plateau (maintained depolarization) due to Ca2+ inflow when voltage-gated slow Ca2+ channels open and K+ outflow when some K+ channels open
- Repolarization due to closure of Ca2+ channels and K+ outflow when additional voltage-raged K+ channels open
How does the refractory period differ in cardiac muscle compared to skeletal muscle?
Another contraction cannot begin until relaxation is well under way thus, tetanus (maintained contraction) cannot occur
Describe the 3 following waves in an ECG: P wave, QRS complex, and T wave
P wave - small upward deflect on the ECG representing atrial depolarization which spreads from the SA node though contractile fibers in both atria
QRS complex - begins as a downward deflection and then contained as a upright triangular eave and then back down representing rapid ventricular depolarization as the PA spreads through the ventricular contractile fibers
T wave - smaller and wider upward deletion that indicates ventricular depolarization as the ventricles start to relax
- The ECG is flat during the plateau period of steady depolarization
What is the clinical significant of ECG readings?
The size of waves can provide clues on abnormalities
Ex. large P wave indicates enlargement of atrium, large Q wave may indicate myocardial infarction, large R wave indicated enlarged ventricles, flat T waves indicates lack of oxygen
How do ECG waves correlate with atrial and ventricular diastole?
- Depolarization of atrial contractile fibers produces P wave
- Atrial systole (contraction)
- Depolarization of ventricular contractive fibers produces QRS complex
- Ventricular systole (contraction)
- Depolarization of ventricular contractive fibers produces T wave
- Ventricular diastole (relaxation)