Chapter 2: Medically Relevant Bacteria (2) Flashcards

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1
Q

Staphylococcus aureus is commonly found in which part of the body?

A

nose

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2
Q

S. aureus is catalase negative or positive?

A

positive

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3
Q

S. aureus is coagulase negative or positive?

A

positive

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4
Q

Staph aureus has what hemolytic pattern?

A

Beta hemolytic

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5
Q

Compare and contrast: α, β, and γ hemolysis?

A

α: Partial hemolysis (greenish brownish zone)
β: complete hemolysis (clear zone)
γ: no hemolysis (no change)

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6
Q

Distinguishing features of Staph aureus?

A
  • ferments mannitol
  • salt tolerant
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7
Q

Disease Presentations of S. Aureus?

A
  • Infective endocarditis (acute)
  • abscesses and mastitis
  • TSST: desquamating rash, fever, hypotension
  • Gastroenteritis: 2-6 h onset, salt foods, custards
  • Supprative lesions, pyoderma, impetigo
  • Penumonia: nosocimial, typical, acute
  • # 1 osteomyelitis unless HbS mentioned
  • septic arthritis
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8
Q

S. epidermidis is catalase negative or positive?

A

positive

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9
Q

S. epidermidis is coagulase negative or positive?

A

negative

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10
Q

Hemolysis pattern of S. epidermidis?

A

γ

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11
Q

Distinguishing features of S. epidermidis.

A
  • Novobiocin sensitive (does not like to grow on)
  • Biofilm producer
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12
Q

3 Staph species?

A

S. aureus
S. epidermidis
S. saprophyticus

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13
Q

Disease presentations associated with S. epidermidis?

A
  • endocarditis in IV drug users
  • catheter and prosthetic device infections
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14
Q

S. saprophyticus is catalase negative or catalase positvie?

A

positive

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15
Q

S. saprophyticus is coagulase negative or positive?

A

negative

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16
Q

Hemolysis pattern of S. saprophyticus.

A

γ

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17
Q

What are some distinguishing feature of S. saprophyticus?

A

NovobiocinR

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18
Q

What are some disease presentations associated with S. saprophyticus?

A

UTIs in newly sexually active females

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19
Q

Group A strep other name basically?

A

S. pyogenes

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20
Q

S. pyogenes is catalase negative or positive?

A

negative

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21
Q

S. pyogenes is coagulase negative or positive?

A

negative

22
Q

S. pyogenes hemolytic pattern?

A

β

23
Q

Distinguishing features of S. pyogenes.

A

Bacitracin S
PYR (pyrrolidonyl arylamidase)

24
Q

Disease presentations of S. pyogenes?

A
  • pharyngitis
  • scarlet fever
  • pyoderma/ impetigo
  • suppurative lesions
  • rheumatic fever
  • acute glomerulonephritis
25
Q

Group B strep name?

A

S. agalactiae

26
Q

Is S. agalactiae catalase negative or positive?

A

negative

27
Q

Is S. agalactiae coagulase negative or positive?

A

negative

28
Q

Hemolytic pattern found in S. agalactiae?

A

β

29
Q

Distinguishing features of S. agalactiae?

A
  • BacitracinR
  • CAMP+
30
Q

Disease presentations of S. agalactiae?

A

neonatal septicemia and meningitis

31
Q

Non groupable strep names?

A

S. pneumoniae and Viridans group.

32
Q

S. pneumoniae catalase negative or positive?

A

negative

33
Q

S. pneumoniae coagulase negative or positive?

A

negative

34
Q

Hemolytic pattern of S. pneumoniae?

A

α

35
Q

Distinguishing features of S. pneumoniae?

A
  • OptochinS
  • Bile soluble
36
Q

Disease presentation association with S. pneumoniae.

A
  • pneumonia (community acquired)
  • adult meningitis
  • otitis media and sinusitis in children
37
Q

Viridans group strep catalase negative or positive?

A

negative

38
Q

Viridans group strep coagulase negative or positive?

A

negative

39
Q

Viridans group strep hemolytic pattern?

A

α/γ

40
Q

Distinguishing features of viridans group strep?

A
  • OptochinR
  • Bile-insoluble
41
Q

Disease presentation associated with Viridans group strep?

A
  • infective endocarditis
  • dental caries
42
Q

Group D strep ?

A

Enterococcus sp.

43
Q

Enterococcus is catalase negative or positive?

A

negative

44
Q

Enterococcus sp. is coagulase negative or positive?

A

negative

45
Q

Hemolytic pattern of enterococcus?

A

α, β, γ

46
Q

Distinguishing features of Enterococcus sp.?

A
  • PYR (pyrrolidonyl arylamidase)
  • Bile- insoluble
  • Esculin agar
47
Q

Disease presentations associated with Enterococcus?

A
  • infective endocarditis
  • urinary and biliary infections
48
Q

Create a gram positive organisms flow chart chart outlining differentiation of Gram positive cocci.

A
49
Q

Describe Transmission of Staph aureus?

A
  • hands
  • sneezing
  • surgical wounds
  • contaminated food
    -custard pastries
    -potato salad
    -canned meats
50
Q

Predisposing factors of Staph aureus.

A
  • surgery/wounds
  • foreign body (tampons, surgical packing, sutures)
  • severe neutropenia (< 500/uL)
  • IV drug abuse
  • CGD
  • cystic fibrosis
51
Q

Pathogenesis of Staph aureus.

A
  • Protein A bind Fc component of IgG, inhibiting phagocytosis
  • Enterotoxins: fast acting, heat stable
  • toxic shock syndrome toxin-1 (TSST-1): superantigenn
  • coagulase: converts fibrinogen to fibrin clot
  • cytolytic toxin (α toxin): pore-forming toxin, Panton-Valentine leukocidin (PVL), forms pores in infected cells and is acquired by bacteriophage; assocated with increased virulence, MRSA strains
  • Exfoliatins: skin exfoliating toxins (involved in scalded skin syndrome (SSS) and bullous impetigo