Chapter 2

Question 1

4 phases of Wound Healing?

Answer 1

1. Hemostasis- Fibrin Clot Formation
2. Inflammation- Cellular Infiltration
3. Proliferation- Reepithelization, fibroblasts, angiogenesis
4. Maturation- collagen remodeling

Question 2

What is cachexia?

Answer 2

Weight loss, muscle atrophy, and fatigue that occur in chronic disease (e.g., cancer, AIDS, heart failure, COPD)

Mediated by TNF-alpha, IFN-gamma, IL-1, IL-6

In cancer-related cachexia, high levels of pro-inflammatory cytokines lead to increased ubiquitination