Chapter 16- Salivary Glands Flashcards

1
Q

What is xerostomia

A

Dry mouth from a decrease in the production of saliva

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How does xerostomia present

A

Dry mucosa

Atrophy of the tongue papillae with fissuring and ulcerations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Patients with xerostonia present with higher rates of what

A
  • Dental caries
  • Cadidiasis
  • difficulty swallowing and speaking
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the most common type of inflammatory salivary gland lesion

A

Mucoceles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the most common type of viral sialadenitis

A

Mumps, which affects the parotid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the cause of mucocele

A

Lesion of the salivary gland from blockage or rupture of the salivary gland duct, leading to leakage into the connective tissue stroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the most common cause of mucoceles

A

Trauma, usually on the lower lip

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the clinical presentation of mucocele

A
  • Swelling of the lower lip with a blue tint to it

- Changes in size of the lesion, especially with meals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Histologically, what are mucoceles composed of

A
  • Psedocysts which have cyst spaces lined inflammatory granulation tissue/connective tissue
  • Spaces filled with mucin and macrophages
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the treatment of the mucocele

A

Excision of the cyst along with the accompanying minor salivary gland

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the it called when there is an epithelial lined cyst that has arisen due to damage to the sublingual duct

A

Randal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the term used for when there is a cyst that has dissected the connective tissue and has connected the two bellies of the myohyloid bellies

A

Plunging ranula

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the common bacterial causes non-specific sialadenitis, and what is the common duct affected

A

Submandibular gland blocked by stones, usually as a result of S. Aureus or Sptrept viridans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Patients under which treatment can commonly develop decreased secretory function

A

Phenothiazines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which patients are at an increased risk of developing bacterial suppurative parotitis

A

Elderly patients with recent major thoracic or abdominal surgery and are dehydrated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the rule for bilateral versus unilateral in obstructive or inflammatory of glands

A

Unilateral is the rule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Most neoplasms of the salivary glands arise in which location

A

Parotid gland

18
Q

How common are neoplasms of the salivary glands

A

Not very common at all

19
Q

What is the relationship between the size of the salivary gland and the risk for a neoplasm

A

The smaller the gland is, the more likely it is to develop a neoplasm (parotid is the lowest, sublingual the highest)

20
Q

Which patient population is more likely to develop Warthin tumors

A

Males (higher risk of smoking, which predisposes)

21
Q

What will be the prevention of all parotid neoplasms

A

Distinctive swelling in front of and below the ear

22
Q

What are the cells the make up the pleomorphic adenomas

A

Mixture of ductal cells (epithelial) and myoepithelial cells (mesenchymal)

23
Q

What is the most common tumor in the parotid gland and what is its prevalence in other glands

A

Pleomorphic adenoma, rarely found in any other than the parotid gland

24
Q

What is known to increase the risk for a pleomorphic adenine

A

Radiation exposure

25
What is the chromosomal rearrangement that is commonly associated with the formation of pleomorphic adenomas
PLAG1
26
What is the prognosis of pleomorphic adenomas
Benign tumor
27
What is the histological features of the pleomorphic adenomas
Resemble ductal cells or myoepithelial cells arrange in a ductal formation
28
In most cases of pleomorphic adenomas, what is there no evidence of
- No epithelial dysplasia | - No mitotic activity
29
How will a pleomorphic adenoma present to the clinic
-Painless, slow growing, mobile, discrete masses within the parotid or submandibular areas or buccal cavity
30
What is the prognosis of a pleomorphic adenoma becomes a mixed malignant tumor
Not good, as it is one of the most invasive salivary tumors
31
What is the location that the papillary cystadenoma lymphomatosum usually arises in
Parotid gland
32
What is the patient group that the papillary cystadenoma lymphomatosum will arise in
Male smokers
33
Which condition is histologically known to contain a granular appearance of the cytoplasm of the upper layer of cells due large number of mitochondria
Aka oncytic cell see in Warthin tumors
34
Which cells are included in mucoepidermoid carcinoma
Mixture of squamous cells, mucus secreting cells, and intermediate cells
35
Which condition is associated with the translocation (11;19)(q21;p13)
Mucoepidermoid carcinoma
36
What is the condition associated with MECT1/MAML2 fusion genes
Mucoepidermoid carcinoma
37
What is the most common form of primary malignant tumor of the salivary glands
Mucoepidermoid carcinoma
38
Which pathway is affected by the MECT1 and MAML2 fusion gene
CAMP and Notch
39
What is the histological pattern seen in mucoepidermoid carcinomas
- Lack well defined capsules and infiltrating at the margins - Contain mucin filled cysts - Cords/sheets of squamous, mucous, and intermediate cells
40
What is the common location that adenoid system carcinoma is found
50% in the minor salivary glands, especially the palatine glands
41
What salivary gland tumor has reports of invading the nose, sinuses and upper airways, or the cribriform plate aka perineural spaces
Adenoid cystic carcinoma
42
Which form of adenoid cystic carcinoma have a poorer prognosis than others
Minor salivary glands have a worse prognosis when compared to parotid glands