Chapter 16 - Integumentary System

Question 1

Melanocytes are found in which
epidermal layer?

(A) Stratum basale
(B) Stratum corneum
(C) Stratum granulosum
(D) Stratum lucidum
(E) Stratum spinosum

Answer 1

A. Stratum Basale

Melanocytes are found in the stratum basale, the deepest layer of the epidermis, at the
dermoepidermal junction.

Question 2

A young black girl shows isolated patches
of skin and hair that lack melanin pigment.
In addition, other skin lesions are observed
that look suspiciously like a malignant
melanoma. What is the most likely
diagnosis?

(A) Type I oculocutaneous albinism
(B) Type II oculocutaneous albinism
(C) Piebaldism
(D) Ichthyosis
(E) Psoriasis

Answer 2

C. Piebaldism

Piebaldism is an autosomal dominant disorder and is basically a localized albinism.

Question 3

A young infant shows extremely
stretchable and fragile skin, hypermobile
joints, and cigarette-paper scars over the
knees. What is the most likely diagnosis?

(A) Ehlers-Danlos syndrome
(B) Junctional epidermolysis bullosa
(C) Psoriasis
(D) Ichthyosis
(E) Piebaldism

Answer 3

A. Ehlers - Danlos Syndrome

Ehlers-Danlos syndrome is an autosomal dominant disorder involving the gene for peptidyl
lysine hydroxylase.

Question 4

A young infant shows skin blisters over
the entire body with generalized skin
erosion. Pathology indicates a cleft between
the epidermis and dermis. What is the most
likely diagnosis?

(A) Psoriasis
(B) Junctional epidermolysis bullosa
(C) Ichthyosis
(D) Ehlers-Danlos syndrome
(E) Type II oculocutaneous albinism

Answer 4

B. Junctional epidermolysis bullosa

Junctional epidermolysis bullosa refers to a group of autosomal recessive disorders
caused by a mutation in the gene for laminin 5.

Question 5

The administration of which of the
following agents may result in discoloration
of both deciduous and permanent teeth?

(A) Cephalosporin
(B) Chloramphenicol
(C) Erythromycin
(D) Penicillin
(E) Tetracycline

Answer 5

E. Tetracycline

Tetracyclines are bound to calcium in newly formed teeth both in utero and in young
children. They may cause discoloration and enamel dysplasia.