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PHARMACOLOGY > CHAPTER 16 > Flashcards

CHAPTER 16 Flashcards

1
Q

It protects the body from injury and pathogens using chemical mediators.

A

Inflammatory Response

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2
Q

Signs of inflammation

A

Swelling
Fevers
Aches
Pain

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3
Q

It can lead to tissue damage and increased inflammatory reactions.

A

Chronic Inflammation

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4
Q

It block or alter chemical reactions associated with inflammation to reduce symptoms.

A

Antiinflammatory agents

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5
Q

It block the inflammatory and immune systems, with systemic use causing significant adverse effects and reduced infection resistance.

can also be used topically for localized effects with fewer side effects.

A

Corticosteroids

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6
Q

block histamine’s role in initiating inflammation.

A

Antihistamine

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7
Q

are used for chronic disorders like rheumatoid arthritis and Crohn’s disease.

A

Immune modulating agents

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8
Q

It include salicylates, nonsteroidal antiinflammatory drugs (NSAIDs), and antiarthritis drugs.

A

Common antiinflammatory drugs

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9
Q

It can lead to abuse, overdosing, misdiagnosis, and toxicity.

A

Over-the-counter (OTC) antiinflammatory drugs

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10
Q

More susceptible to gastrointestinal (GI) and central nervous system (CNS) effects of antiinflammatory drugs

A

Children

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11
Q

Must be cautious of the presence of antiinflammatory drugs in OTC products to avoid toxicity.

A

Adults

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12
Q

Proper dosing is crucial, especially with over-the-counter (OTC) products.

A

Children

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13
Q

Only recommended salicylates for children are

A

choline magnesium trisalicylate and aspirin (not first choice).

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14
Q

Antiinflammatory drugs should not be used if there is a risk of:

A

Reye syndrome, particularly after viral infections.

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15
Q

Approved NSAIDs for children include

A

Ibuprofen
Naproxen
Tolmetin
Meloxicam
Indomethaxin (sometimes)

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16
Q

It is commonly used, but overdose can cause severe hepatotoxicity to CHILDREN.

A

Acetaminophen

17
Q

Children with arthritis may be treated with what? requiring close monitoring for toxicity.

A

Gold salts or Etanercept

18
Q

Pregnant and nursing women should avoid these drugs unless necessary, due to risks to the fetus or neonate.

A

Antiinflammatory Drugs

19
Q

may be used cautiously; nondrug measures are preferred for ADULTS.

A

Acetaminophen

20
Q

used for arthritis are particularly toxic in OLDER ADULTS, potentially causing renal, GI, and liver problems; doses should be reduced and patients closely monitored.

A

Gold salts

21
Q

Treatment of fever, pain, inflammatory condi-tions; at low dose to prevent the risk of death and Mi in patients with history of Ml, prevention of transient ischemic attacks

A

Apsirin

22
Q

Treatment of fever, pain, inflammatory condi-tions; at low dose to prevent the risk of death and Mi in patients with history of Ml, prevention of transient ischemic attacks

A

Apsirin

23
Q

Treatment of mildly to moderately acute ulcerative colitis in adults

A

Balsalazide

24
Q

Relief of mild pain, fevers; treatment of arthritis

A

Choline Magnesium Trisalicylate

25
Q

Treatment of moderate pain, arthritis in adults

A

Difunisal

26
Q

Treatment of ulcerative colitis and other inflammatory bowel disease in adults

A

Mesalmine and Osalazine

27
Q

Treatment of pain, fever, inflammation in adults

A

Salsalate

28
Q

Inhibit prostaglandin synthesis ,reducing inflammation. Have antipyretic effects by blocking prostaglandin mediators of pyrogens in the hypothalamus.

A

Salicytes

29
Q

Used to treat mild to moderate pain,f ever, & inflammatory conditions like rheumatoid arthritis & osteoarthritis.

A

Salicylates

30
Q

are absorbed from the stomach, reaching peak levels in 5 to 30 minutes.
- Metabolized in the liver and excreted in the urine; half-life ranges from 15 minutes to12hours.
- They cross the placenta and enter breastmilk; not recommended during pregnancy or lactation due to risks.

A

Salicytes

31
Q

caused by high aspirin levels, can result in dizziness, tinnitus, hearing loss, nausea, vomiting, confusion, and fatigue.

A

Salicylism

32
Q

Treatment of acute and chronic pain associated with inflammatory conditions in adults

A

Diclofenac

33
Q

Found in many tissues, important for homeostasis

A

COX - 1

34
Q

Induced by inflammatory stimuli at the site of inflammation

A

COX 2

35
Q

Acts on the hypothalamus to reduce fever by causing sweating and vasodilation.

A

Acetaminophen

36
Q
  • are used to treat arthritis by aggressively targeting the inflammatory process.
  • the Increasingly selected early in the diagnosis to prevent joint damage.
A

Disease-Modifying Antirheumatic Drugs

37
Q

2 types of DMARD

A

Tumor Necrosis Factor
Blockers and other DMARDS

38
Q
  • Often the first class of drugs used for progressing arthritis.
A

Tumor Necrosis Factor Blockers

39
Q

THF Blockers

A

Adalimumab
Certolizumab
Entanercept
Golimumab
Infliximab

PHARMACOLOGY (6 decks)

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