Chapter 16 Flashcards
Where is glucagon secreted from?
Alpha cells of pancreas
Why are cats more susceptible to post prandial hyperglycaemia?
They rely on hexokinase to metabolise glucose in cells (slower than glucokinase used by dogs)
When is artefactual hypoglycaemia most likely?
When serum not separated quickly
Erythrocytosis
Leucocytosis
What is fructosamine?
Plasma proteins non-enzymatically and irreversibly glycosylated
What factors can artifactually lower fructosamine?
Hypoalbuminaemia
Hyperlipidaemia (D)
Azotaemia (D)
Hyperthyroidism
What can artifactually elevate fructosamine?
Hypothyroidism
Ddx hypoglycaemia
Increased use - sepsis, neoplasia, seizure, exercise
Decreased production - hepatic disease, hypoadrenocorticism, neonatal, glycogen storage disease, enzyme deficiencies
Increased insulin/hypoglycaemic agent - overdose, insulinoma, xylitol, sulfonylureas, neoplasia
What is the mechanism by which xylitol causes hypoglycaemia?
Stimulates insulin release from beta cells
