Chapter 15

Question 1

Salvage recovery

Answer 1

Biosynthetic pathway that uses or recycles intermediates from the corresponding degradative pathway.

Question 2

5-Phophoribosyl-1-pyrophosphate (PRPP)

Answer 2

supplies ribose phosphate in the synthesis of purines and pyrimidines

Question 3

Nucleoside Monophosphate Kinase

Answer 3

Enzyme catalyzing the transfer of a terminal phosphate group from ATP to a nucleoside monophosphate

Question 4

Nucleoside Diphosphate Kinase

Answer 4

Enzyme catalyzing the transfer of a terminal phosphate group from a nucleoside triphosphate to a nucleoside diphosphate

Question 5

Ribonucleotide Reductase

Answer 5

Enzyme that converts ribonucleotide diphosphate to deoxyribonucleotide diphosphate, with concomitant oxidation of NADPH to NADP+.

Question 6

Thimidylate Synthase

Answer 6

Enzyme that methylates deoxyuridylate to form deoxythymidylate

Question 7

5-Flourouricil

Answer 7

an analog of uracil; activated in the body to give 5-fluoro-deoxyuridylate(F-dUMP), a suicide substrate for thymidylate synthase.

Question 8

Gout

Answer 8

a disease of the joints caused by high serum levels of uric acid(urate)

Question 9

Lesch-Nyhan Syndrome

Answer 9

A rare inheritable disorder that is due to a lack of activity of the enzyme hypoxanthine-guanine phosphoribosyl transferase

Question 10

Hypoxanthine

Answer 10

6-Hydroxypurine

Question 11

Inosine

Answer 11

Purine nucleoside in which the base is hypoxanthine

Question 12

Hypoxanthine-Guanine Phosphoribosyl Transferase

Answer 12

Enzyme involved in the purine salvage pathway; a lack of this enzyme leads to Lesch-Nyhan syndrome

Question 13

Urate/ Uric Acid

Answer 13

2,6,8-Trihydroxypurine, or 7,9-dihydro-1H-purine-2,6,8(3H)-trione

Question 14

Xanthine Oxidase

Answer 14

enzyme which catalyzes oxidation of hypoxanthine to xanthine, and xanthine to uric acid