Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

2H SystemPATHO RBC > Chapter 14 – Red Blood Cell and Bleeding Disorders > Flashcards

Chapter 14 – Red Blood Cell and Bleeding Disorders Flashcards

1
Q

What is ANEMIA?

A

Anemia is defined as a reduction of the total circulating red cell mass below normal limits .

Anemia reduces the oxygen-carrying capacity of the blood, leading to tissue hypoxia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How is anemia diagnosed?

A

​ In
practice, the measurement of red cell mass is not easy, and anemia is usually diagnosed based
on a reduction in the hematocrit (the ratio of packed red cells to total blood volume) and the
hemoglobin concentration of the blood to levels that are below the normal range.

These values
correlate with the red cell mass except when there are changes in plasma volume caused by
fluid retention or dehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is hematocrit?

A

hematocrit is the ratio of packed red cells to total blood volume

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is hemoglobin?

A

hemoglobin concentration of the blood to levels that are below the normal range.

These values
correlate with the red cell mass except when there are changes in plasma volume caused by
fluid retention or dehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the second clinical useful approach classifies anemia?

A

A second clinically useful approach classifies anemia according to alterations in red cell morphology, which often point to particular causes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Morphologic
characteristics providing etiologic clues include what?

A

Morphologic
characteristics providing etiologic clues include red cell:

  • size (normocytic, microcytic, or macrocytic);
  • degree of hemoglobinization, reflected in the color of red cells (normochromic or hypochromic); and
  • shape.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Red cell size is classified as what?

A
  • normocytic,
  • microcytic, or
  • macrocytic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

degree of hemoglobinization

A

reflected in the color of red cells (normochromic or
hypochromic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

In general, microcytic hypochromic anemias are caused by what?

A

disorders of hemoglobin synthesis (most often iron deficiency)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

macrocytic anemias often stem from
abnormalities that______________

A

impair the maturation of erythroid precursors in the bone marrow.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Normochromic, normocytic anemias have diverse etiologies; in some of these anemias, specific
abnormalities of red cell shape (best appreciated through visual inspection of peripheral
smears) provide an important clue as to the cause.

The other indices can also be assessed
qualitatively in smears, but precise measurement is carried out in clinical laboratories with
special instrumentation.

The most useful red cell indices are as follows:

A
  • Mean cell volume
  • Mean cell hemoglobin
  • Mean cell hemoglobin concentration
  • Red cell distribution width
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Mean cell volume

A

Mean cell volume: the average volume of a red cell expressed in femtoliters (fL)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Mean cell hemoglobin

A

the average content (mass) of hemoglobin per red cell,
expressed in picograms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Mean cell hemoglobin concentration

A

the average concentration of hemoglobin in a given volume of packed red cells, expressed in grams per deciliter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Red cell distribution width

A

: the coefficient of variation of red cell volume

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

Mechanism

A
  • BLOOD LOSS
  • INCREASED RED CELL DESTRUCTION (HEMOLYSIS)
  • DECREASED RED CELL PRODUCTION
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

BLOOD LOSS

Acute blood loss

Specific Examples

A

Trauma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

BLOOD LOSS

Chronic blood loss

Specific Examples

A
  • Gastrointestinal tract lesions,
  • gynecologic disturbances
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

A
  • Inherited genetic defects
    • Red cell membrane disorders
    • Enzyme deficiencies
    • Hemoglobin abnormalities
  • Acquired genetic defects
    • Deficiency of
      phosphatidylinositol-linked
      glycoproteins
    • Antibody-mediated destruction
    • Mechanical trauma
    • Microangiopathic hemolytic
      anemias
    • Cardiac traumatic hemolysis
    • Repetitive physical trauma
    • Infections of red cells
    • Toxic or chemical injury
    • Membrane lipid abnormalities
    • Sequestration
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

Acquired genetic defects

A
  • Deficiency of phosphatidylinositol-linked glycoproteins
  • Antibody-mediated destruction
  • Mechanical trauma
  • Microangiopathic hemolytic anemias
  • Cardiac traumatic hemolysis
  • Repetitive physical trauma
  • Infections of red cells
  • Toxic or chemical injury
  • Membrane lipid abnormalities
  • Sequestration
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

Enzyme deficiencies

A
  • Hexose monophosphate shunt enzyme deficiencies
  • Glycolytic enzyme deficiencies
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

DECREASED RED CELL PRODUCTION

Nutritional deficiencies

A
  • Deficiencies affecting DNA synthesis
  • Deficiencies affecting hemoglobin synthesis
  • Erythropoietin deficiency
  • Immune-mediated injury of progenitors
  • Inflammation-mediated iron sequestration
  • Primary hematopoietic neoplasms
  • Space-occupying marrow lesions
  • Infections of red cell progenitors
  • Unknown mechanisms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

DECREASED RED CELL PRODUCTION

Inherited genetic defects

A
  • Defects leading to stem cell depletion
  • Defects affecting erythroblast maturation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

Inherited genetic defects

Red cell membrane disorders

A
  • Hereditary spherocytosis,
  • hereditary elliptocytosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

Inherited genetic defects

Enzyme deficiencies

Hexose monophosphate shunt
enzyme deficiencies

A
  • G6PD deficiency,
  • glutathione synthetase deficiency
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

Inherited genetic defects

Enzyme deficiencies

Glycolytic enzyme deficiencies

A
  • Pyruvate kinase deficiency,
  • hexokinase deficiency
27
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Inherited genetic defects
    • Enzyme deficiencies
      • Glycolytic enzyme deficiencies
A
  • Pyruvate kinase deficiency,
  • hexokinase deficiency
28
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Inherited genetic defects
    • Hemoglobin abnormalities
      • ​Deficient globin synthesis
A

Thalassemia syndromes

29
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Inherited genetic defects
    • Hemoglobin abnormalities
      • Structurally abnormal globins (hemoglobinopathies)
A
  • Sickle cell disease,
  • unstable hemoglobins
30
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Deficiency of phosphatidylinositol-linked glycoproteins
A

Paroxysmal nocturnal hemoglobinuria

31
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Antibody-mediated destruction
A
  • Hemolytic disease of the newborn (Rh disease),
  • transfusion reactions,
  • drug-induced,
  • autoimmune disorders
32
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Mechanical trauma
A

Hemolytic disease of the newborn (Rh disease), transfusion reactions, drug-induced, autoimmune disorders

33
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Microangiopathic hemolytic anemias
A
  • Hemolytic uremic syndrome,
  • disseminated intravascular coagulation,
  • thrombotic thrombocytopenia purpura
34
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Cardiac traumatic hemolysis
A

Defective cardiac valves

35
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Repetitive physical trauma
A
  • Bongo drumming,
  • marathon running,
  • karate chopping
36
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Infections of red cells
A

Malaria, babesiosis

37
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Toxic or chemical injury
A
  • Clostridial sepsis,
  • snake venom,
  • lead poisoning
38
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Membrane lipid abnormalities
A
  • Abetalipoproteinemia,
  • severe hepatocellular liver disease
39
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

  • Acquired genetic defects
    • Sequestration
A

Hypersplenism

40
Q

DECREASED RED CELL PRODUCTION

  • Inherited genetic defects
    • Defects leading to stem cell depletion
A
  • Fanconi anemia,
  • telomerase defects
41
Q

DECREASED RED CELL PRODUCTION

  • Inherited genetic defects
    • Defects affecting erythroblast maturation
A

Thalassemia syndromes

42
Q

DECREASED RED CELL PRODUCTION

  • Nutritional deficiencies
    • Deficiencies affecting DNA synthesis
A

B12 and folate deficiencies

43
Q

DECREASED RED CELL PRODUCTION

  • Nutritional deficiencies
    • Deficiencies affecting hemoglobin synthesis
A

Iron deficiency anemia

44
Q

DECREASED RED CELL PRODUCTION

  • Nutritional deficiencies
    • Erythropoietin deficiency
A

Renal failure, anemia of chronic disease

45
Q

DECREASED RED CELL PRODUCTION

  • Nutritional deficiencies
    • Immune-mediated injury of
      progenitors
A

Aplastic anemia, pure red cell aplasia

46
Q

DECREASED RED CELL PRODUCTION

  • Nutritional deficiencies
    • Inflammation-mediated iron
      sequestration
A

Anemia of chronic disease

47
Q

DECREASED RED CELL PRODUCTION

  • Nutritional deficiencies
    • Primary hematopoietic neoplasms
A

Acute leukemia, myelodysplasia, myeloproliferative disorders (
Chapter 13 )

48
Q

DECREASED RED CELL PRODUCTION

  • Nutritional deficiencies
    • Space-occupying marrow lesions
A
  • Metastatic neoplasms,
  • granulomatous disease
49
Q

DECREASED RED CELL PRODUCTION

  • Nutritional deficiencies
    • Infections of red cell progenitors
A

Parvovirus B19 infection

50
Q

DECREASED RED CELL PRODUCTION

  • Nutritional deficiencies
    • Unknown mechanisms
A

Endocrine disorders, hepatocellular liver disase

51
Q

Most often cause anemia due to iron deficiency, not bleeding per se.

A

gynecologic disturbances

52
Q

Whatever its cause, when sufficiently severe anemia leads to certain clinical features.

A
  • Patients appear pale.
  • Weakness,
  • malaise,
  • and easy fatigability are common complaints.
  • The lowered oxygen content of the circulating blood leads to dyspnea on mild exertion
  • . Hypoxia can cause fatty change in the liver, myocardium, and kidney.
  • If fatty changes in the myocardium are sufficiently severe, cardiac failure can develop and compound the tissue hypoxia caused by the deficiency of O2 in the blood.
  • On occasion, the myocardial hypoxia manifests as angina pectoris, particularly when complicated by pre-existing coronary artery disease.
  • With acute blood loss and shock, oliguria and anuria can develop as a result of renal hypoperfusion.
  • Central nervous system hypoxia can cause headache, dimness of vision, and faintness.
53
Q

The effects of acute blood loss are mainly due to what?

A

the loss of intravascular volume, which if
massive can lead to cardiovascular collapse, shock, and death.

54
Q

In acute blood loss, how is it restored?

A

If the patient
survives, the blood volume is rapidly restored by the intravascular shift of water from the
interstitial fluid compartment.

This fluid shift results in hemodilution and a lowering of the hematocrit.

The reduction in oxygenation triggers increased secretion of erythropoietin from the
kidney, which stimulates the proliferation of committed erythroid progenitors (CFU-E) in the
marrow (see Fig. 13-1 ).

55
Q

How long does it takes for the progeny of these CFU-Es to mature and
appear as newly released red cells (reticulocytes) in the peripheral blood.

A

about 5 days

56
Q

How is the iron in the hemoglobin recaptured?

A

The iron in
hemoglobin is recaptured if red cells extravasate into tissues, whereas bleeding into the gut or
out of the body leads to iron loss and possible iron deficiency, which can hamper the restoration
of normal red cell coun

57
Q

Significant bleeding results in predictable changes in the blood involving not only red cells, but
also white cells and platelets

T or F

58
Q

What is the reason for leukocytosis when there is a mssive bleeding?

A

If the bleeding is sufficiently massive to cause a decrease in blood pressure, the compensatory release of adrenergic hormones mobilizes granulocytes from
the intravascular marginal pool and results in leukocytosis

59
Q

What is the appearance of RBC initially in acute blood loss?

A

Initially, red cells
appear normal in size and color (normocytic, normochromic).

However, as marrow production
increases there is a striking increase in the reticulocyte count (reticulocytosis), which reaches
10% to 15% after 7 days

60
Q

What is the appearance of reticulocytes?

A

Reticulocytes are larger in size than normal red cells (macrocytes) and have a blue-red polychromatophilic cytoplasm

61
Q

.Early recovery from blood loss is also often
accompanied by thrombocytosis, which results from an increase in platelet production.

T or F

62
Q

When does chronic blood loss induces anemia?

A

Chronic blood loss induces anemia only when the rate of loss exceeds the regenerative
capacity of the marroworwhen iron reserves are depleted and iron deficiency anemia appears;
this will be discussed later

2H SystemPATHO RBC (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions