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2H SystemPATHO RBC > Chapter 14 – Red Blood Cell and Bleeding Disorders > Flashcards

Chapter 14 – Red Blood Cell and Bleeding Disorders Flashcards

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1
Q

What is ANEMIA?

A

Anemia is defined as a reduction of the total circulating red cell mass below normal limits .

Anemia reduces the oxygen-carrying capacity of the blood, leading to tissue hypoxia.

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2
Q

How is anemia diagnosed?

A

​ In
practice, the measurement of red cell mass is not easy, and anemia is usually diagnosed based
on a reduction in the hematocrit (the ratio of packed red cells to total blood volume) and the
hemoglobin concentration of the blood to levels that are below the normal range.

These values
correlate with the red cell mass except when there are changes in plasma volume caused by
fluid retention or dehydration

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3
Q

What is hematocrit?

A

hematocrit is the ratio of packed red cells to total blood volume

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4
Q

What is hemoglobin?

A

hemoglobin concentration of the blood to levels that are below the normal range.

These values
correlate with the red cell mass except when there are changes in plasma volume caused by
fluid retention or dehydration

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5
Q

What is the second clinical useful approach classifies anemia?

A

A second clinically useful approach classifies anemia according to alterations in red cell morphology, which often point to particular causes.

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6
Q

Morphologic
characteristics providing etiologic clues include what?

A

Morphologic
characteristics providing etiologic clues include red cell:

  • size (normocytic, microcytic, or macrocytic);
  • degree of hemoglobinization, reflected in the color of red cells (normochromic or hypochromic); and
  • shape.
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7
Q

Red cell size is classified as what?

A
  • normocytic,
  • microcytic, or
  • macrocytic
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8
Q

degree of hemoglobinization

A

reflected in the color of red cells (normochromic or
hypochromic)

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9
Q

In general, microcytic hypochromic anemias are caused by what?

A

disorders of hemoglobin synthesis (most often iron deficiency)

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10
Q

macrocytic anemias often stem from
abnormalities that______________

A

impair the maturation of erythroid precursors in the bone marrow.

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11
Q

Normochromic, normocytic anemias have diverse etiologies; in some of these anemias, specific
abnormalities of red cell shape (best appreciated through visual inspection of peripheral
smears) provide an important clue as to the cause.

The other indices can also be assessed
qualitatively in smears, but precise measurement is carried out in clinical laboratories with
special instrumentation.

The most useful red cell indices are as follows:

A
  • Mean cell volume
  • Mean cell hemoglobin
  • Mean cell hemoglobin concentration
  • Red cell distribution width
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12
Q

Mean cell volume

A

Mean cell volume: the average volume of a red cell expressed in femtoliters (fL)

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13
Q

Mean cell hemoglobin

A

the average content (mass) of hemoglobin per red cell,
expressed in picograms

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14
Q

Mean cell hemoglobin concentration

A

the average concentration of hemoglobin in a given volume of packed red cells, expressed in grams per deciliter

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15
Q

Red cell distribution width

A

: the coefficient of variation of red cell volume

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16
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

Mechanism

A
  • BLOOD LOSS
  • INCREASED RED CELL DESTRUCTION (HEMOLYSIS)
  • DECREASED RED CELL PRODUCTION
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17
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

BLOOD LOSS

Acute blood loss

Specific Examples

A

Trauma

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18
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

BLOOD LOSS

Chronic blood loss

Specific Examples

A
  • Gastrointestinal tract lesions,
  • gynecologic disturbances
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19
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

A
  • Inherited genetic defects
    • Red cell membrane disorders
    • Enzyme deficiencies
    • Hemoglobin abnormalities
  • Acquired genetic defects
    • Deficiency of
      phosphatidylinositol-linked
      glycoproteins
    • Antibody-mediated destruction
    • Mechanical trauma
    • Microangiopathic hemolytic
      anemias
    • Cardiac traumatic hemolysis
    • Repetitive physical trauma
    • Infections of red cells
    • Toxic or chemical injury
    • Membrane lipid abnormalities
    • Sequestration
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20
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

Acquired genetic defects

A
  • Deficiency of phosphatidylinositol-linked glycoproteins
  • Antibody-mediated destruction
  • Mechanical trauma
  • Microangiopathic hemolytic anemias
  • Cardiac traumatic hemolysis
  • Repetitive physical trauma
  • Infections of red cells
  • Toxic or chemical injury
  • Membrane lipid abnormalities
  • Sequestration
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21
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

Enzyme deficiencies

A
  • Hexose monophosphate shunt enzyme deficiencies
  • Glycolytic enzyme deficiencies
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22
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

DECREASED RED CELL PRODUCTION

Nutritional deficiencies

A
  • Deficiencies affecting DNA synthesis
  • Deficiencies affecting hemoglobin synthesis
  • Erythropoietin deficiency
  • Immune-mediated injury of progenitors
  • Inflammation-mediated iron sequestration
  • Primary hematopoietic neoplasms
  • Space-occupying marrow lesions
  • Infections of red cell progenitors
  • Unknown mechanisms
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23
Q

TABLE 14-1 – Classification of Anemia According to Underlying Mechanism

DECREASED RED CELL PRODUCTION

Inherited genetic defects

A
  • Defects leading to stem cell depletion
  • Defects affecting erythroblast maturation
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24
Q

INCREASED RED CELL DESTRUCTION (HEMOLYSIS)

Inherited genetic defects

Red cell membrane disorders

A
  • Hereditary spherocytosis,
  • hereditary elliptocytosis
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25
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) Inherited genetic defects Enzyme deficiencies Hexose monophosphate shunt enzyme deficiencies
* G6PD deficiency, * glutathione synthetase deficiency
26
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) Inherited genetic defects Enzyme deficiencies Glycolytic enzyme deficiencies
* Pyruvate kinase deficiency, * hexokinase deficiency
27
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Inherited genetic defects * Enzyme deficiencies * Glycolytic enzyme deficiencies
* Pyruvate kinase deficiency, * hexokinase deficiency
28
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Inherited genetic defects * **Hemoglobin abnormalities** * **​Deficient globin synthesis**
Thalassemia syndromes
29
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Inherited genetic defects * Hemoglobin abnormalities * Structurally abnormal globins (hemoglobinopathies)
* Sickle cell disease, * unstable hemoglobins
30
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * Deficiency of phosphatidylinositol-linked glycoproteins
Paroxysmal nocturnal hemoglobinuria
31
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * **Antibody-mediated destruction**
* Hemolytic disease of the newborn (Rh disease), * transfusion reactions, * drug-induced, * autoimmune disorders
32
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * Mechanical trauma
Hemolytic disease of the newborn (Rh disease), transfusion reactions, drug-induced, autoimmune disorders
33
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * Microangiopathic hemolytic anemias
* Hemolytic uremic syndrome, * disseminated intravascular coagulation, * thrombotic thrombocytopenia purpura
34
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * Cardiac traumatic hemolysis
Defective cardiac valves
35
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * Repetitive physical trauma
* Bongo drumming, * marathon running, * karate chopping
36
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * Infections of red cells
Malaria, babesiosis
37
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * Toxic or chemical injury
* Clostridial sepsis, * snake venom, * lead poisoning
38
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * Membrane lipid abnormalities
* Abetalipoproteinemia, * severe hepatocellular liver disease
39
INCREASED RED CELL DESTRUCTION (HEMOLYSIS) * Acquired genetic defects * Sequestration
Hypersplenism
40
DECREASED RED CELL PRODUCTION * Inherited genetic defects * Defects leading to stem cell depletion
* Fanconi anemia, * telomerase defects
41
DECREASED RED CELL PRODUCTION * Inherited genetic defects * Defects affecting erythroblast maturation
Thalassemia syndromes
42
DECREASED RED CELL PRODUCTION * Nutritional deficiencies * Deficiencies affecting DNA synthesis
B12 and folate deficiencies
43
DECREASED RED CELL PRODUCTION * Nutritional deficiencies * Deficiencies affecting hemoglobin synthesis
Iron deficiency anemia
44
DECREASED RED CELL PRODUCTION * Nutritional deficiencies * Erythropoietin deficiency
Renal failure, anemia of chronic disease
45
DECREASED RED CELL PRODUCTION * Nutritional deficiencies * Immune-mediated injury of progenitors
Aplastic anemia, pure red cell aplasia
46
DECREASED RED CELL PRODUCTION * Nutritional deficiencies * Inflammation-mediated iron sequestration
Anemia of chronic disease
47
DECREASED RED CELL PRODUCTION * Nutritional deficiencies * Primary hematopoietic neoplasms
Acute leukemia, myelodysplasia, myeloproliferative disorders ( Chapter 13 )
48
DECREASED RED CELL PRODUCTION * Nutritional deficiencies * Space-occupying marrow lesions
* Metastatic neoplasms, * granulomatous disease
49
DECREASED RED CELL PRODUCTION * Nutritional deficiencies * Infections of red cell progenitors
Parvovirus B19 infection
50
DECREASED RED CELL PRODUCTION * Nutritional deficiencies * Unknown mechanisms
Endocrine disorders, hepatocellular liver disase
51
Most often cause anemia due to iron deficiency, not bleeding per se.
gynecologic disturbances
52
Whatever its cause, when sufficiently severe anemia leads to certain clinical features.
* Patients appear pale. * Weakness, * malaise, * and easy fatigability are common complaints. * The lowered oxygen content of the circulating blood leads to dyspnea on mild exertion * . Hypoxia can cause fatty change in the liver, myocardium, and kidney. * If fatty changes in the myocardium are sufficiently severe, cardiac failure can develop and compound the tissue hypoxia caused by the deficiency of O2 in the blood. * On occasion, the myocardial hypoxia manifests as angina pectoris, particularly when complicated by pre-existing coronary artery disease. * With acute blood loss and shock, oliguria and anuria can develop as a result of renal hypoperfusion. * Central nervous system hypoxia can cause headache, dimness of vision, and faintness.
53
The effects of acute blood loss are mainly due to what?
**the loss of intravascular volume,** which if massive can lead to cardiovascular collapse, shock, and death.
54
In acute blood loss, how is it restored?
If the patient survives, the blood volume is rapidly restored by the **intravascular shift of water from the interstitial fluid compartment**. This fluid shift **results in hemodilution and a lowering of the hematocrit.** The **reduction in oxygenation triggers increased secretion of erythropoietin** from the kidney, which **stimulates the proliferation of committed erythroid progenitors (CFU-E) in the marrow (see Fig. 13-1 ).**
55
How long does it takes for the progeny of these CFU-Es to mature and **appear as newly released red cells (reticulocytes) in the peripheral blood.**
about 5 days
56
How is the iron in the hemoglobin recaptured?
The iron in hemoglobin is recaptured if **red cells extravasate into tissues**, whereas **bleeding into the gut or out of the body leads to iron loss and possible iron deficiency**, which can hamper the restoration of normal red cell coun
57
Significant bleeding results in predictable changes in the blood involving not only red cells, **but also white cells and platelets** **T or F**
True
58
What is the reason for leukocytosis when there is a mssive bleeding?
If the bleeding is sufficiently massive to cause a **decrease in blood pressure**, the **compensatory release of adrenergic hormones *_mobilizes granulocytes from the intravascular marginal pool and results in leukocytosis_***
59
What is the appearance of RBC initially in acute blood loss?
Initially, red cells appear normal in size and color **(normocytic, normochromic).** However, as marrow production increases there is a striking increase in the reticulocyte count (reticulocytosis), which reaches **10% to 15% after 7 days**
60
What is the appearance of reticulocytes?
Reticulocytes are **larger in size** than normal red cells **(macrocytes)** and have a **blue-red polychromatophilic cytoplasm**
61
.Early recovery from blood loss is also often accompanied by thrombocytosis, which results from an increase in platelet production. T or F
True
62
When does chronic blood loss induces anemia?
Chronic blood loss induces anemia only when the rate of loss **exceeds the regenerative capacity of the marrow**or**when iron reserves are depleted** and iron deficiency anemia appears; this will be discussed later
63

2H SystemPATHO RBC (2 decks)

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