Chapter 14 - Alpha Substitution Reactions of Carbonyls

Question 1

Halogenation of a ketone under basic conditions will form _____ while the same reaction under acidic conditions will make ____

Answer 1

tetra substituted product with halogen

mono substituted product with halogen

Question 2

Haloform Reaction

Answer 2

a ketone is treated with OH and xs halogen to form a carboxylate ion, then quenched to make COOH

Question 3

What must the starting compound be in the haloform reaction?

Answer 3

methyl ketone

Question 4

Aldol Condensation

Answer 4

aldehyde is treated with base and water to make a beta hydroxy aldehyde

Question 5

A beta hydroxy aldehyde can be treated with xs acid or base and heat to make _____

Answer 5

alpha beta unsaturated aldehyde

Question 6

Claisen Condensation

Answer 6

similar to aldol condensation

ester is treated with a base to make a beta ketone ester

Question 7

In order for formation of a beta ketone ester from an ester in the Claisen condensation, the _____ and the ____ from the starting compound must _____

Answer 7

reagent, ester group, match

Question 8

Beta Decarboxylation

Answer 8

a beta keto ester is treated with a base and heat to form a ketone