Chapter 13.4

Question 1

Peripheral B-cell neoplasms

Answer 1

• Chronic Lymphocytic leukemia
• Small lymphocytic leukemia
• Follicular lymphoma
• Diffuse Large B-cell Lymphoma
• Burkitt Lymphoma

Question 2

Difference bw CLL and SLL

Answer 2

-only differ in the degree of peripheral blood lymphocytosis; most patients have sufficient lymphocytosis to fulfill the diagnostic requirement for CLL

Question 3

Most common leukemia of adults in the Western world

Answer 3

• CLL!
• median age at Dx is 60; 2:1 male predominance; in contrast SLL constitutes only 4% of NHLs
• CLL/SLL is much less common in Japan and other Asian countries than the West

Question 4

Pathogenesis of CLL/SLL–genetics

Answer 4

• unlike other lymphoid malignancies, chromosomal translocations are rare in CLL/SLL
• THE MOST COMMON GENETIC ANOMALIES ARE DELETIONS OF 13q14.3, 11q and 17p and trisomyq
• tumor suppressor genes: two micro RNAS: miR 15a and miR-16=1
• DNA sequencing has revealed that the Ig genes of some CLL/SLL are somatically hyper mutated whereas others are not suggesting the cell of origin may be either a post germinal center memory B cell or a naive B cell