Chapter 133 Chronic Myeloid Leukemia Flashcards
1
Q
Translocation characteristic for CML?
A
t(9;22) - Philadelphia chromosome
Give rise to BCR ABL1 chimeric gene product
2
Q
Most common physical exam finding in CML?
A
Splenomegaly
3
Q
What hematologic finding in CML when present suggests a worse prognosis, disease acceleration, or an unrelated etiology?
A
Thrombocytopenia
Usually thrombocytosis
4
Q
Treatment of CML?
A
Imatinib (A tyrosine kinase inhibitor) - targets the unique gene product of the Philadelphia chromosome: BCR ABL1
(Nilotinib, Dasatinib)
5
Q
Diagnosis of CML?
A
PCR of the BCR ABL gene
