Chapter 13: Ethers and epoxides Flashcards
1
Q
Preparation of ethers via SN2
A
(1) H3O+ to protonate a primary alcohol
(2) substitute with the same starting alcohol
2
Q
Williamson Ether Synthesis
A
(1) NaH to deprotonate an alcohol
(2) An alkyl halide
3
Q
Alkoxymercuration-demercuration
A
(1) Hg(OAc)2, ROH
(2) NaBH4
4
Q
Acidic cleavage of an ether
A
HI or HBr
5
Q
Epoxide formation
A
(1) Br2, H2O
(2) NaOH
6
Q
Epoxide Ring opening with a strong nucleophe
A
Strong nucleophile attacks at less substituted position
7
Q
Acid-catalyzed ring opening
A
Need H3O+
Water or alcohol attacks at more substituted position
