Chapter 13: Adrenergic Drugs Affecting the ANS pathophysiology of SNS Flashcards

1
Q

What is the Sympathetic Nervous system

A

prepares the body for stressful or energetic activity, fight or flight

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2
Q

What is the neurotransmitter for the SNS

A

Norepinephrine

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3
Q

sympathomimetics

A

activates or increase the activity of the SNS - activating fight of flight

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4
Q

What are the receptors for the SNS

A
  • Alpha 1: vasoconstriction and pupillary dilation
  • Alpha 2: inhibition of release of NE
  • Beta 1: Increased HR and contractility, release of renin from kidneys
  • Beta 2: inhibition of smooth muscle
  • Beta 3: Lipolysis (break down of fat for energy), relaxation of detruser muscle in bladder - why animals/humans urinate on self in fight or flight mode
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5
Q

What can we use Sympathomimetics for?

A
  • Nasal Congestion and Hypotension
  • Dilation of pupils for eye exam
  • cardiac arrest, heart failure, shock
  • Asthma/COPD
  • premature labor
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6
Q

Contraindications for Sympathomimetics

A
  • Narrow-angle glaucoma (because of pupillary dilation)
  • patients with existing heart disease
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7
Q

What are sympatholytics?

A

inhibit the SNS
- decreased vasoconstriction
- decreased pupillary dilation
- inhibition of release of NE
- decreased HR
- decreases contractility
- decrease in release of renin from kidneys
- decrease inhibition of smooth muscle
- decreased lipolysis
- decreased relaxation of detrusor muscle

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8
Q

What can we treat with sympatholytics?

A
  • HTN (d/t vessel dilation)
  • Narrow-angle glaucoma (d/t pupillary constriction)
  • Angina, Heart Failure, Dysrhythmias (d/t decreased HR and Contractility)
  • BPH (d/t smooth muscle relaxation
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9
Q

sympatholytics adverse effects

A

d/t vasodilation
- Dizziness
- Reflex tachycardia
- priapism/inhibition of ejaculation
-headache

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