Chapter 13: Adrenergic Drugs Affecting the ANS pathophysiology of SNS Flashcards
What is the Sympathetic Nervous system
prepares the body for stressful or energetic activity, fight or flight
What is the neurotransmitter for the SNS
Norepinephrine
sympathomimetics
activates or increase the activity of the SNS - activating fight of flight
What are the receptors for the SNS
- Alpha 1: vasoconstriction and pupillary dilation
- Alpha 2: inhibition of release of NE
- Beta 1: Increased HR and contractility, release of renin from kidneys
- Beta 2: inhibition of smooth muscle
- Beta 3: Lipolysis (break down of fat for energy), relaxation of detruser muscle in bladder - why animals/humans urinate on self in fight or flight mode
What can we use Sympathomimetics for?
- Nasal Congestion and Hypotension
- Dilation of pupils for eye exam
- cardiac arrest, heart failure, shock
- Asthma/COPD
- premature labor
Contraindications for Sympathomimetics
- Narrow-angle glaucoma (because of pupillary dilation)
- patients with existing heart disease
What are sympatholytics?
inhibit the SNS
- decreased vasoconstriction
- decreased pupillary dilation
- inhibition of release of NE
- decreased HR
- decreases contractility
- decrease in release of renin from kidneys
- decrease inhibition of smooth muscle
- decreased lipolysis
- decreased relaxation of detrusor muscle
What can we treat with sympatholytics?
- HTN (d/t vessel dilation)
- Narrow-angle glaucoma (d/t pupillary constriction)
- Angina, Heart Failure, Dysrhythmias (d/t decreased HR and Contractility)
- BPH (d/t smooth muscle relaxation
sympatholytics adverse effects
d/t vasodilation
- Dizziness
- Reflex tachycardia
- priapism/inhibition of ejaculation
-headache