Chapter 12: Nervous Tissue Flashcards

1
Q

What role does nervous tissue play in homeostasis?

A

Nervous tissue helps maintain homeostasis by generating nerve impulses (action potentials) that regulate body organs.

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2
Q

How does the nervous system differ from the endocrine system in maintaining homeostasis?

A

The nervous system acts quickly through nerve impulses, while the endocrine system uses hormones to maintain homeostasis.

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3
Q

What is the study of the nervous system’s functions and disorders called?

A

Neurology.

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4
Q

What are the two main parts of the nervous system?

A

The Central Nervous System (CNS) and the Peripheral Nervous System (PNS).

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5
Q

What is the primary function of the CNS?

A

The CNS processes sensory information and is the center for thoughts, emotions, memories, and signals controlling muscle movement and gland secretion.

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6
Q

What does the PNS consist of?

A

The PNS consists of all nervous tissue outside the CNS, including cranial and spinal nerves.

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7
Q

What are sensory receptors?

A

Sensory receptors are structures that monitor changes in the internal or external environment and send sensory information to the CNS.

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8
Q

What are the two divisions of the PNS?

A

The sensory (afferent) division and the motor (efferent) division.

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9
Q

What is the function of the sensory (afferent) division of the PNS?

A

It sends sensory information from the body’s receptors to the CNS.

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10
Q

What is the role of the motor (efferent) division of the PNS?

A

It sends signals from the CNS to effectors like muscles and glands.

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11
Q

What does the somatic nervous system (SNS) control?

A

The SNS controls voluntary actions of skeletal muscles.

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12
Q

What is the autonomic nervous system (ANS) responsible for?

A

The ANS controls involuntary actions of smooth muscles, cardiac muscles, and glands.

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13
Q

What are the three subdivisions of the ANS?

A

The sympathetic nervous system, parasympathetic nervous system, and enteric nervous system.

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14
Q

How do the sympathetic and parasympathetic nervous systems differ in function?

A

The sympathetic nervous system is responsible for “fight-or-flight” responses, while the parasympathetic nervous system controls “rest-and-digest” activities.

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15
Q

What are the three main functions of the nervous system?

A

Sensory function, integrative function, and motor function.

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16
Q

What does the sensory function of the nervous system involve?

A

Sensory receptors detect stimuli (e.g., changes in blood pressure or external sensations) and send this information to the CNS.

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17
Q

What occurs during the integrative function of the nervous system?

A

The nervous system processes and analyzes sensory information to decide how to respond.

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18
Q

What is the motor function of the nervous system?

A

The motor function involves sending signals to muscles or glands to trigger actions like muscle contractions or gland secretions.

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19
Q

Provide an example of the three main functions of the nervous system.

A

When a phone rings:
- Sensory: Ears detect the sound.
- Integrative: The brain processes the information and decides to answer.
- Motor: The brain sends signals to muscles to pick up the phone and press the answer button.

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20
Q

What are the two types of cells in nervous tissue?

A

Neurons and neuroglia.

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21
Q

What is the role of neurons?

A

Neurons connect all regions of the body to the brain and spinal cord, enabling functions like sensing, thinking, remembering, controlling muscles, and regulating glands.

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22
Q

What is the role of neuroglia?

A

Neuroglia support, nourish, protect neurons, and maintain the fluid around them. They can divide throughout life.

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23
Q

How do the structure of neurons and neuroglia differ in the CNS and PNS?

A

The structure varies to reflect their different roles in the central and peripheral nervous systems.

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24
Q

What is electrical excitability in neurons?

A

Neurons have the ability to respond to stimuli and generate action potentials, which are electrical signals that travel along their membranes.

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25
Q

What is an action potential?

A

An action potential is an electrical signal that travels along the neuron’s membrane, caused by the movement of ions like sodium and potassium.

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26
Q

How fast can a nerve impulse travel?

A

Nerve impulses can travel at speeds ranging from 0.5 to 130 meters per second (1 to 290 mph).

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27
Q

What are the three main parts of a neuron?

A

The cell body (soma), dendrites, and axon.

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28
Q

What is the function of the cell body in a neuron?

A

The cell body contains the nucleus, cytoplasm, and organelles, and it supports neuron growth and repairs damaged axons in the PNS.

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29
Q

What are dendrites?

A

Dendrites are short, branched extensions that receive signals from other neurons.

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30
Q

What is the function of the axon?

A

The axon transmits nerve impulses away from the neuron to other cells.

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31
Q

What is the role of neurofibrils and microtubules in neurons?

A

Neurofibrils provide shape and support, while microtubules help move materials between the cell body and axon.

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32
Q

What is lipofuscin and how does it affect neurons?

A

Lipofuscin is a pigment that accumulates in neurons as they age but does not harm them.

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33
Q

What is a ganglion?

A

A ganglion is a collection of neuron cell bodies outside the CNS.

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34
Q

What is the difference between dendrites and axons?

A

Dendrites receive signals, while axons transmit nerve impulses.

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35
Q

What is a synapse?

A

A synapse is the communication site between two neurons or between a neuron and an effector cell.

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36
Q

What are synaptic end bulbs and varicosities?

A

They are structures at the ends of axons that contain synaptic vesicles, which store neurotransmitters.

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37
Q

What are neurotransmitters?

A

Neurotransmitters are chemicals released from synaptic vesicles that affect the activity of other cells.

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38
Q

What is slow axonal transport?

A

Slow axonal transport moves materials from the cell body to the axon terminals at a rate of 1–5 mm per day.

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39
Q

What is fast axonal transport?

A

Fast axonal transport moves materials from the cell body to the axon terminals at 200–400 mm per day, and it can occur in both directions.

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40
Q

What are the two types of axonal transport?

A

Slow axonal transport (moves materials in one direction) and fast axonal transport (moves materials in both directions).

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41
Q

What is the structural diversity of neurons?

A

Neurons vary in size and shape, including the size of the cell body, dendritic branching, and axon length.

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42
Q

What are multipolar neurons?

A

Multipolar neurons have many dendrites and one axon. They are common in the brain and spinal cord.

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43
Q

What are bipolar neurons?

A

Bipolar neurons have one dendrite and one axon. They are found in areas like the retina, inner ear, and olfactory region of the brain.

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44
Q

What are unipolar (pseudounipolar) neurons?

A

Unipolar neurons have a single process that splits into dendrites and an axon. They are primarily sensory neurons.

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45
Q

What are Purkinje cells?

A

Purkinje cells are large neurons in the cerebellum with elaborate dendritic branching.

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46
Q

What are pyramidal cells?

A

Pyramidal cells are neurons in the cerebral cortex with pyramid-shaped cell bodies.

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47
Q

What are sensory neurons (afferent neurons)?

A

Sensory neurons transmit information from sensory receptors to the CNS and are typically unipolar.

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48
Q

What are interneurons (association neurons)?

A

Interneurons process sensory information and generate motor responses, primarily in the CNS. They are usually multipolar.

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49
Q

What are motor neurons (efferent neurons)?

A

Motor neurons transmit action potentials from the CNS to effectors (muscles or glands) in the PNS. They are typically multipolar.

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50
Q

What are gliomas?

A

Gliomas are brain tumors that arise from glial cells, are highly malignant, and grow rapidly.

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51
Q

What are the types of neuroglia in the CNS?

A

Astrocytes, oligodendrocytes, microglia, and ependymal cells.

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52
Q

What is the function of astrocytes?

A

Astrocytes provide structural support, maintain the blood-brain barrier, and regulate the chemical environment of the brain.

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53
Q

What are the two types of astrocytes?

A

Protoplasmic astrocytes (found in gray matter) and fibrous astrocytes (found in white matter).

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54
Q

What are oligodendrocytes?

A

Oligodendrocytes produce myelin sheaths around CNS axons.

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55
Q

What are microglia?

A

Microglia act as immune cells in the CNS, responding to injury and disease.

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56
Q

What are ependymal cells?

A

Ependymal cells line the ventricles of the brain and help produce cerebrospinal fluid (CSF).

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57
Q

What are Schwann cells?

A

Schwann cells myelinate PNS axons.

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58
Q

What are satellite cells?

A

Satellite cells provide support and nutrients to neurons in the PNS.

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59
Q

What is myelination?

A

Myelination is the process where axons are surrounded by a multilayered lipid and protein covering, the myelin sheath, which electrically insulates the axon and speeds up nerve impulse conduction.

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60
Q

What cells produce myelin in the PNS?

A

Schwann cells produce myelin in the PNS.

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61
Q

What cells produce myelin in the CNS?

A

Oligodendrocytes produce myelin in the CNS.

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62
Q

How do Schwann cells form myelin?

A

Schwann cells start forming myelin sheaths during fetal development by wrapping around a single axon, creating multiple layers of membrane, and forming the neurolemma in the PNS.

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63
Q

What is the neurolemma?

A

The neurolemma is the outer layer of a Schwann cell’s cytoplasm and nucleus, found only in the PNS.

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64
Q

What happens if an axon is injured in the PNS?

A

If an axon is injured, the neurolemma helps regenerate the axon by forming a tube that guides and stimulates regrowth.

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65
Q

What are Nodes of Ranvier?

A

Nodes of Ranvier are gaps in the myelin sheath at intervals along the axon, allowing for faster nerve impulse conduction.

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66
Q

How do oligodendrocytes myelinate axons in the CNS?

A

Oligodendrocytes extend flat processes that wrap around multiple CNS axons to form a myelin sheath, but do not create a neurolemma.

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67
Q

Why is there limited regrowth in the CNS?

A

Limited regrowth occurs in the CNS due to the absence of a neurolemma and the inhibitory effect of oligodendrocytes.

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68
Q

How does myelination affect the speed of nerve impulses?

A

Myelination significantly increases the speed of nerve impulse conduction, which improves coordination as myelination develops from infancy to maturity.

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69
Q

What is the difference between gray and white matter?

A

Gray matter contains neuronal cell bodies, dendrites, and unmyelinated axons, while white matter is made up of myelinated axons.

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70
Q

What are ganglia?

A

Ganglia are groups of neuronal cell bodies located in the PNS, often associated with cranial and spinal nerves.

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71
Q

What is a nucleus in the context of the nervous system?

A

A nucleus is a cluster of neuronal cell bodies located in the CNS.

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72
Q

What is the difference between nerves and tracts?

A

Nerves are bundles of axons in the PNS, while tracts are bundles of axons in the CNS.

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73
Q

What is the role of gray matter?

A

Gray matter is involved in processing and integrating information and contains cell bodies, dendrites, unmyelinated axons, axon terminals, and neuroglia.

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74
Q

What is the role of white matter?

A

White matter is responsible for transmitting nerve impulses between different parts of the nervous system, consisting of myelinated axons.

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75
Q

How does the distribution of gray and white matter differ in the brain and spinal cord?

A

In the spinal cord, white matter surrounds an inner core of gray matter. In the brain, gray matter covers the cerebrum and cerebellum, while white matter lies beneath.

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76
Q

What are graded potentials?

A

Graded potentials are small electrical changes used for short-distance communication in neurons.

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77
Q

What are action potentials?

A

Action potentials are large electrical signals used for long-distance communication within the body, also known as nerve impulses.

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78
Q

What are the two key features of excitable cells that generate electrical signals?

A

Resting membrane potential and ion channels are key features that allow excitable cells to generate electrical signals.

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79
Q

What are ion channels?

A

Ion channels are proteins in the plasma membrane that allow specific ions to flow across the membrane, generating electrical currents.

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80
Q

What is the difference between concentration and electrical gradients in ion movement?

A

Ions move from areas of higher to lower concentration (concentration gradient) and from positively charged areas to negatively charged areas (electrical gradient).

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81
Q

What are leak channels?

A

Gated channels that randomly open and close.

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82
Q

Where are leak channels located in neurons?

A

Found in nearly all cells, and in the dendrites, cell bodies, and axons of all types of neurons.

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83
Q

What are ligand-gated channels?

A

Gated channels that open in response to the binding of a ligand (e.g., Acetylcholine).

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84
Q

Where are ligand-gated channels located in neurons?

A

Found in the dendrites of some sensory neurons like pain receptors, and in the dendrites and cell bodies of interneurons and motor neurons.

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85
Q

What are mechanically gated channels?

A

Gated channels that open in response to a mechanical stimulus, such as touch, pressure, vibration, or tissue stretching.

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86
Q

Where are mechanically gated channels located in neurons?

A

Found in the dendrites of some sensory neurons like touch receptors, pressure receptors, and some pain receptors.

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87
Q

What are voltage-gated channels?

A

Gated channels that open in response to a voltage stimulus (change in membrane potential).

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88
Q

Where are voltage-gated channels located in neurons?

A

Located in the axons of all types of neurons.

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89
Q

What causes the resting membrane potential in neurons?

A

The resting membrane potential arises from a slight accumulation of negative ions in the cytosol and positive ions in the extracellular fluid (ECF), creating potential energy.

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90
Q

How is the resting membrane potential measured?

A

Using a recording microelectrode inserted inside the cell and a reference electrode in the ECF, connected to a voltmeter to measure the electrical difference across the plasma membrane.

91
Q

What does a negative resting membrane potential indicate?

A

A negative resting membrane potential indicates that the inside of the cell is more negative than the outside.

92
Q

What is the typical range for the resting membrane potential in neurons?

A

It typically ranges from −40 mV to −90 mV, with a common value of −70 mV.

93
Q

What does it mean if a cell has a membrane potential?

A

A cell with a membrane potential is described as polarized. Most body cells are polarized, with membrane potentials varying from +5 mV to −100 mV.

94
Q

What are the three main factors contributing to the resting membrane potential?

A
  1. Unequal ion distribution, 2. Inability of anions to leave, 3. Electrogenic nature of Na⁺–K⁺ ATPases.
95
Q

How does unequal ion distribution affect the resting membrane potential?

A

The ECF has high Na⁺ and Cl⁻, while the cytosol has K⁺ and negatively charged molecules, creating a charge difference across the membrane.

96
Q

Why can’t most anions leave the cell?

A

Most anions are bound to larger molecules like ATP and proteins, preventing them from leaving the cell and contributing to the negative charge inside.

97
Q

How do Na⁺–K⁺ ATPases contribute to the resting membrane potential?

A

Na⁺–K⁺ ATPases actively pump 3 Na⁺ out for every 2 K⁺ they bring in, removing more positive charges than they bring in, contributing to the cell’s negativity.

98
Q

What is the typical contribution of Na⁺–K⁺ ATPases to the resting membrane potential in neurons?

A

They contribute about −3 mV to the typical −70 mV resting membrane potential.

99
Q

What is a graded potential?

A

A graded potential is a small change in the resting membrane potential, which can either hyperpolarize or depolarize the membrane.

100
Q

What is a hyperpolarizing graded potential?

A

It occurs when the inside of the cell becomes more negative relative to the outside.

101
Q

What is a depolarizing graded potential?

A

It occurs when the inside of the cell becomes less negative or more positive relative to the outside.

102
Q

How do graded potentials form?

A

Graded potentials form in response to the opening of mechanically-gated or ligand-gated channels.

103
Q

What determines the amplitude of a graded potential?

A

The amplitude depends on how many ion channels open or close and for how long, with stronger stimuli causing larger changes.

104
Q

What is decremental conduction in graded potentials?

A

It is the decrease in strength of a graded potential as it spreads from its origin.

105
Q

How does summation affect graded potentials?

A

Graded potentials can combine to become stronger (depolarizing or hyperpolarizing), or cancel each other out if opposite in nature.

106
Q

What are postsynaptic potentials?

A

Graded potentials that occur in response to neurotransmitters in the dendrites or cell body of a neuron.

107
Q

What are receptor potentials?

A

Graded potentials that occur in sensory receptors.

108
Q

What is an action potential?

A

An action potential is a series of events where the membrane potential changes quickly, first decreasing and reversing, then returning to its resting state. It consists of depolarizing and repolarizing phases.

109
Q

What are the two main phases of an action potential?

A
  1. Depolarizing phase: Membrane potential becomes less negative and then positive.
  2. Repolarizing phase: Membrane potential is restored to its resting state of -70 mV.
110
Q

What is the after-hyperpolarizing phase?

A

It is a phase where the membrane potential becomes more negative than usual after the repolarizing phase, temporarily reaching about -90 mV before returning to the resting state.

111
Q

What types of voltage-gated channels open during an action potential?

A
  1. Na+ channels open first, causing depolarization.
  2. K+ channels open next, causing repolarization and, if open too long, leading to the after-hyperpolarizing phase.
112
Q

What triggers the action potential in the axon?

A

The action potential is triggered when depolarization reaches a certain threshold, usually about -55 mV, at the trigger zone.

113
Q

What is a subthreshold stimulus?

A

A subthreshold stimulus is a weak depolarization that does not reach the threshold, so no action potential occurs.

114
Q

What is a threshold stimulus?

A

A threshold stimulus is strong enough to depolarize the membrane to the threshold, generating one action potential.

115
Q

What is a suprathreshold stimulus?

A

A suprathreshold stimulus is a stronger stimulus that causes multiple action potentials, but the amplitude of each action potential remains the same regardless of the stimulus strength.

116
Q

How does the all-or-none principle apply to action potentials?

A

The action potential either happens fully or not at all. If the stimulus is strong enough to reach the threshold, an action potential is generated; if it’s too weak (subthreshold), no action potential occurs.

117
Q

What happens during the depolarizing phase of an action potential?

A

During the depolarizing phase, Na+ channels open, allowing Na+ ions to rush into the cell, causing the membrane potential to become positive (+30 mV). This process involves a positive feedback loop.

118
Q

How does the inactivation of Na+ channels contribute to the repolarizing phase?

A

During the repolarizing phase, Na+ channels close (inactivation gates close), stopping the flow of Na+, while K+ channels open, allowing K+ ions to leave the cell, which causes the membrane potential to drop back to -70 mV.

119
Q

What causes the after-hyperpolarizing phase?

A

The after-hyperpolarizing phase occurs when K+ channels remain open too long, causing excess K+ to leave the cell, temporarily making the membrane potential more negative (around -90 mV).

120
Q

What are the absolute and relative refractory periods?

A
  1. Absolute refractory period: No second action potential can occur, no matter how strong the stimulus.
  2. Relative refractory period: A second action potential can occur, but only with a stronger-than-usual stimulus.
121
Q

How does the size of axons affect their refractory periods and impulse transmission?

A

Larger axons have shorter refractory periods, allowing for faster impulse transmission, while smaller axons have longer refractory periods and transmit fewer impulses per second.

122
Q

What is propagation in terms of action potentials?

A

Propagation refers to the movement of the action potential along the axon, where the depolarization in one area causes nearby channels to open, regenerating the action potential in the next segment of the membrane.

123
Q

How does saltatory conduction differ from continuous conduction?

A

Saltatory conduction occurs in myelinated axons where the action potential “leaps” from one node of Ranvier to the next, speeding up transmission. Continuous conduction occurs in unmyelinated axons and involves step-by-step depolarization.

124
Q

What factors affect the speed of action potential propagation?

A
  1. Amount of myelination: Myelinated axons conduct faster.
  2. Axon diameter: Larger axons conduct faster.
  3. Temperature: Cooler temperatures slow propagation.
125
Q

What are the three classes of nerve fibers and their characteristics?

A
  1. A fibers: Largest, myelinated, fast conduction (12–130 m/sec).
  2. B fibers: Smaller, myelinated, moderate speed (up to 15 m/sec).
  3. C fibers: Smallest, unmyelinated, slow conduction (0.5–2 m/sec).
126
Q

How do the characteristics of A, B, and C fibers affect their function?

A

A fibers transmit sensory info and control skeletal muscles. B fibers are involved in autonomic functions and transmitting sensory info from organs. C fibers carry pain and temperature sensations and have the slowest conduction.

127
Q

What is the effect of myelination on action potential propagation speed?

A

Myelinated axons propagate action potentials faster than unmyelinated axons due to the limited distribution of voltage-gated channels, concentrating them at the nodes of Ranvier.

128
Q

Where do graded potentials primarily arise?

A

Graded potentials arise mainly in the dendrites and cell body.

129
Q

Where do action potentials originate and propagate?

A

Action potentials arise at trigger zones and propagate along the axon.

130
Q

What type of ion channels are involved in graded potentials?

A

Graded potentials involve ligand-gated or mechanically-gated ion channels.

131
Q

What type of ion channels are involved in action potentials?

A

Action potentials involve voltage-gated channels for Na⁺ and K⁺.

132
Q

How is conduction different between graded potentials and action potentials?

A

Graded potentials are decremental (not propagated) and communicate over short distances. Action potentials propagate and communicate over longer distances.

133
Q

What is the amplitude size range for graded potentials?

A

The amplitude of graded potentials varies depending on the stimulus strength, from less than 1 mV to more than 50 mV.

134
Q

What is the amplitude of action potentials?

A

Action potentials follow an all-or-none principle, with an amplitude typically around 100 mV.

135
Q

How long do graded potentials last?

A

Graded potentials typically last longer, from several milliseconds to several minutes.

136
Q

How long do action potentials last?

A

Action potentials are shorter, lasting from 0.5 to 2 milliseconds.

137
Q

What is the polarity of graded potentials?

A

Graded potentials can be hyperpolarizing (inhibitory) or depolarizing (excitatory).

138
Q

What is the polarity of action potentials?

A

Action potentials always consist of a depolarizing phase followed by a repolarizing phase and a return to the resting membrane potential.

139
Q

Do graded potentials have a refractory period?

A

Graded potentials do not have a refractory period, and summation can occur.

140
Q

Do action potentials have a refractory period?

A

Action potentials have a refractory period, and summation cannot occur.

141
Q

What is a synapse?

A

A synapse is the area where communication takes place between two neurons or between a neuron and an effector cell.

142
Q

What is the presynaptic neuron?

A

The presynaptic neuron is the nerve cell that transmits a nerve impulse toward the synapse and is responsible for sending the signal.

143
Q

What is the postsynaptic cell?

A

The postsynaptic cell is the cell that receives the signal. It can either be a postsynaptic neuron or an effector cell that responds to the impulse at the synapse.

144
Q

What are the types of synapses between neurons?

A

Synapses between neurons can be axodendritic (between an axon and a dendrite), axosomatic (between an axon and a cell body), or axoaxonic (between two axons).

145
Q

What are the two types of synapses?

A

Synapses can be either electrical or chemical, with differences in their structure and function.

146
Q

How do synapses contribute to homeostasis?

A

Synapses help filter and integrate information, and their structure and function can change during learning, which influences performance.

147
Q

What is an electrical synapse?

A

In an electrical synapse, action potentials travel directly between adjacent neurons through gap junctions, allowing rapid transmission and synchronization.

148
Q

Where are electrical synapses found?

A

Electrical synapses are found in visceral smooth muscle, cardiac muscle, developing embryos, and in the brain.

149
Q

What are the advantages of electrical synapses?

A

Electrical synapses provide faster communication and synchronization of activity among connected neurons or muscle fibers.

150
Q

How does a chemical synapse function?

A

In a chemical synapse, the presynaptic neuron releases neurotransmitters into the synaptic cleft, which bind to receptors on the postsynaptic neuron, creating a postsynaptic potential.

151
Q

What is the synaptic delay in chemical synapses?

A

The synaptic delay at a chemical synapse is about 0.5 milliseconds.

152
Q

What is the process at a chemical synapse?

A

The process includes neurotransmitter release from the presynaptic neuron, binding to receptors on the postsynaptic neuron, and the creation of a postsynaptic potential.

153
Q

What is an excitatory postsynaptic potential (EPSP)?

A

EPSP occurs when a neurotransmitter causes depolarization (decreasing negativity) of the postsynaptic membrane, making the neuron more likely to reach threshold.

154
Q

What is an inhibitory postsynaptic potential (IPSP)?

A

IPSP occurs when a neurotransmitter causes hyperpolarization (increasing negativity) of the postsynaptic membrane, making it harder to trigger an action potential.

155
Q

What is the difference between ionotropic and metabotropic receptors?

A

Ionotropic receptors have the neurotransmitter binding site and ion channel as part of the same protein, while metabotropic receptors are linked to ion channels through G proteins.

156
Q

How do ionotropic receptors function?

A

When a neurotransmitter binds to an ionotropic receptor, it directly opens the ion channel, leading to an EPSP or IPSP in the postsynaptic cell.

157
Q

How do metabotropic receptors function?

A

When a neurotransmitter binds to a metabotropic receptor, it activates a G protein, which can open or close an ion channel or activate a second messenger.

158
Q

What is the role of neurotransmitter receptors?

A

Neurotransmitter receptors bind to specific neurotransmitters and, when activated, lead to changes in the postsynaptic cell’s membrane potential, resulting in either an EPSP or IPSP.

159
Q

What are the three mechanisms of neurotransmitter removal from the synaptic cleft?

A

The three mechanisms are diffusion, enzymatic degradation (e.g., acetylcholinesterase breaks down acetylcholine), and uptake by cells.

160
Q

What is the role of acetylcholinesterase?

A

Acetylcholinesterase is an enzyme that breaks down acetylcholine in the synaptic cleft, preventing prolonged activation of the postsynaptic cell.

161
Q

What is the function of dendrites?

A

Dendrites receive stimuli through the activation of ligand-gated or mechanically-gated ion channels. In sensory neurons, they produce generator or receptor potentials. In motor neurons and interneurons, they produce excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs).

162
Q

What is the function of the cell body?

A

The cell body receives stimuli and produces EPSPs and IPSPs through the activation of ligand-gated ion channels.

163
Q

What happens at the junction of the axon hillock and initial segment of the axon?

A

This junction acts as the trigger zone in many neurons. It integrates EPSPs and IPSPs, and if the sum of these potentials results in depolarization reaching threshold, it initiates the action potential (nerve impulse).

164
Q

What is the function of the axon?

A

The axon propagates nerve impulses from the initial segment (or from dendrites of sensory neurons) to the axon terminals in a self-regenerating manner. The amplitude of the impulse does not change as it propagates along the axon.

165
Q

What is the function of axon terminals and synaptic end bulbs (or varicosities)?

A

The inflow of Ca2+ caused by the depolarizing phase of the nerve impulse triggers exocytosis of neurotransmitters from synaptic vesicles.

166
Q

What are neurotransmitters?

A

Neurotransmitters are chemical substances that neurons use to communicate with other neurons, muscle fibers, and glands.

167
Q

How are neurotransmitters classified?

A

Neurotransmitters are classified into two main categories: small-molecule neurotransmitters and neuropeptides.

168
Q

What is the difference between fast-acting and slow-acting neurotransmitters?

A

Fast-acting neurotransmitters bind to receptors and quickly open or close ion channels. Slow-acting neurotransmitters work through second-messenger systems to influence chemical reactions inside cells, leading to excitation or inhibition of postsynaptic neurons.

169
Q

What role do neurotransmitters play in the endocrine system?

A

Many neurotransmitters also serve as hormones, released into the bloodstream by endocrine cells, and can be released by neurosecretory cells in the brain.

170
Q

What are small-molecule neurotransmitters?

A

Small-molecule neurotransmitters include acetylcholine, amino acids, biogenic amines, ATP and other purines, nitric oxide, and carbon monoxide.

171
Q

What is acetylcholine (ACh) and its function?

A

ACh is a neurotransmitter released by neurons in the PNS and CNS. It can be excitatory at certain synapses (e.g., neuromuscular junction) or inhibitory at others (e.g., parasympathetic neurons).

172
Q

How does acetylcholine (ACh) work at the neuromuscular junction?

A

ACh acts as an excitatory neurotransmitter at the neuromuscular junction, binding to ionotropic receptors and opening cation channels.

173
Q

What is the role of acetylcholinesterase in acetylcholine function?

A

Acetylcholinesterase breaks down acetylcholine into acetate and choline to deactivate it.

174
Q

What are the two types of excitatory amino acid neurotransmitters?

A

Glutamate and aspartate are powerful excitatory neurotransmitters.

175
Q

What is the role of glutamate in the CNS?

A

Glutamate is involved in most excitatory neuron communications in the CNS and is used at about half of the brain’s synapses.

176
Q

How does glutamate activate receptors?

A

When glutamate binds to ionotropic receptors, it opens cation channels, allowing Na+ to flow in, leading to an excitatory postsynaptic potential (EPSP).

177
Q

What are the inhibitory amino acid neurotransmitters?

A

Gamma-aminobutyric acid (GABA) and glycine are inhibitory neurotransmitters.

178
Q

How does GABA function in the CNS?

A

GABA binds to ionotropic receptors, opening Cl− channels, which leads to inhibition of the postsynaptic neuron.

179
Q

How do anti-anxiety medications affect GABA?

A

Medications like diazepam (Valium®) enhance GABA’s effects, promoting inhibitory actions.

180
Q

What are biogenic amines, and which neurotransmitters are included in this group?

A

Biogenic amines are neurotransmitters formed from modified amino acids. They include norepinephrine, epinephrine, dopamine, and serotonin.

181
Q

What are the functions of norepinephrine in the brain?

A

Norepinephrine is involved in arousal (waking from sleep), dreaming, and mood regulation.

182
Q

What is the role of dopamine in the brain?

A

Dopamine regulates emotional responses, addictive behaviors, pleasure, and skeletal muscle tone. Its loss is linked to Parkinson’s disease.

183
Q

What is serotonin involved in?

A

Serotonin is involved in sensory perception, temperature regulation, mood control, appetite, and sleep induction.

184
Q

What is the function of ATP and other purines as neurotransmitters?

A

ATP, ADP, and AMP act as excitatory neurotransmitters in the CNS and PNS, often in combination with other neurotransmitters.

185
Q

How is nitric oxide (NO) different from other neurotransmitters?

A

NO is not stored in vesicles and is made on demand. It is lipid-soluble and acts immediately, with effects lasting less than 10 seconds.

186
Q

What is the role of nitric oxide (NO) in the body?

A

NO is involved in memory, learning, vasodilation, lowering blood pressure, and erectile function.

187
Q

What is carbon monoxide (CO) in terms of neurotransmission?

A

CO is an excitatory neurotransmitter that is produced on demand and plays roles in memory, blood vessel dilation, and regulating body functions.

188
Q

What are neuropeptides?

A

Neuropeptides are neurotransmitters made of 3 to 40 amino acids linked by peptide bonds, and they can act as hormones.

189
Q

What is the role of enkephalins and endorphins?

A

Enkephalins and endorphins are neuropeptides that act as natural painkillers and are more potent than morphine.

190
Q

What is substance P’s role in the body?

A

Substance P transmits pain signals to the CNS and increases the perception of pain. It can be inhibited by enkephalins and endorphins.

191
Q

What is the function of substance P in nerve degeneration?

A

Substance P might help counteract nerve damage and could be useful in treating nerve degeneration.

192
Q

What is the function of Substance P?

A

Found in sensory neurons, spinal cord pathways, and parts of the brain associated with pain; enhances the perception of pain.

193
Q

What is the role of Enkephalins?

A

Inhibit pain impulses by suppressing the release of Substance P; may also play a role in memory and learning, body temperature control, sexual activity, and mental illness.

194
Q

What is the role of Endorphins?

A

Inhibit pain by blocking the release of Substance P; may have a role in memory and learning, sexual activity, body temperature control, and mental illness.

195
Q

What might Dynorphins be related to?

A

May be related to controlling pain and registering emotions.

196
Q

What is a neural circuit?

A

A neural circuit is a functional group of neurons that processes a specific kind of information.

197
Q

What is the structure of a simple series circuit?

A

In a simple series circuit, one neuron stimulates the next in a chain.

198
Q

What is divergence in neural circuits?

A

Divergence occurs when one presynaptic neuron connects with multiple postsynaptic neurons, allowing the presynaptic neuron to send signals to several neurons, muscles, or glands at once.

199
Q

What happens in a diverging circuit?

A

The nerve impulse from a single presynaptic neuron causes the stimulation of increasing numbers of cells along the circuit. For example, a small group of brain neurons can stimulate many neurons in the spinal cord.

200
Q

What is convergence in neural circuits?

A

In convergence, multiple presynaptic neurons connect to a single postsynaptic neuron, allowing the postsynaptic neuron to receive input from different sources.

201
Q

What happens in a converging circuit?

A

The postsynaptic neuron receives nerve impulses from several different sources, making the signal more effective.

202
Q

What is a reverberating circuit?

A

A reverberating circuit is one where the incoming signal stimulates a chain of neurons, and later neurons send signals back to earlier ones, causing the impulse to loop repeatedly through the circuit.

203
Q

What are the functions of a reverberating circuit?

A

Reverberating circuits control actions like breathing, muscle coordination, waking up, and short-term memory.

204
Q

How can the cycle in a reverberating circuit be stopped?

A

Inhibitory neurons can stop the cycle in a reverberating circuit.

205
Q

What is a parallel after-discharge circuit?

A

A parallel after-discharge circuit involves one presynaptic neuron activating a group of neurons that connect to a single postsynaptic cell.

206
Q

How does a parallel after-discharge circuit work?

A

Different numbers of synapses cause varying delays in the signal, leading to multiple responses from the postsynaptic neuron. This type of circuit may help with tasks like solving math problems.

207
Q

What is plasticity in the nervous system?

A

Plasticity is the ability of the nervous system to adapt throughout life through changes like new dendrite growth, new protein production, and altered synaptic connections.

208
Q

What is the ability of neurons in mammals to regenerate?

A

Neurons in mammals have limited ability to regenerate. In the PNS, damaged dendrites and myelinated axons can sometimes heal, but in the CNS, neurons have little to no ability to repair or regrow.

209
Q

What is neurogenesis?

A

Neurogenesis is the birth of new neurons from undifferentiated stem cells.

210
Q

What discovery did Canadian researchers make in 1992 about neurogenesis?

A

In 1992, Canadian researchers found that the protein epidermal growth factor (EGF) stimulated cells from adult mouse brains to proliferate into neurons and astrocytes.

211
Q

What did scientists discover in 1998 about neurogenesis in humans?

A

In 1998, scientists discovered that significant numbers of new neurons arise in the adult human hippocampus, an area crucial for learning.

212
Q

What are the two main factors preventing neurogenesis in the CNS?

A

The two main factors are (1) inhibitory effects from neuroglia, especially oligodendrocytes, and (2) the lack of growth signals that were present during fetal development.

213
Q

How do oligodendrocytes affect neurogenesis?

A

Oligodendrocytes inhibit neuron regeneration in the CNS, unlike Schwann cells in the PNS, by preventing axonal growth and contributing to scar tissue formation.

214
Q

What role do astrocytes play in CNS injuries?

A

After axon damage, astrocytes form scar tissue, which creates a physical barrier to axon regrowth, contributing to the permanence of brain and spinal cord injuries.

215
Q

What is the current state of research in CNS regeneration?

A

Research is ongoing to stimulate spinal cord repair, activate dormant stem cells to replace lost neurons, and create neurons for transplantation.

216
Q

What is the chance of nerve repair in the PNS?

A

If the cell body remains intact and Schwann cells are active, myelinated axons in the PNS can repair themselves, and there is a good chance of nerve function being regained.

217
Q

What happens to the neuron and axon after PNS damage?

A

After PNS damage, the neuron’s cell body undergoes chromatolysis, and the axon distal to the injury swells, fragments, and its myelin sheath deteriorates, in a process known as Wallerian degeneration.

218
Q

What is chromatolysis?

A

Chromatolysis is the breakdown of Nissl bodies in the neuron’s cell body into small granules that occurs about 24 to 48 hours after damage.

219
Q

What is Wallerian degeneration?

A

Wallerian degeneration is the breakdown of the axon and myelin sheath distal to the site of injury, while the neurolemma remains intact.

220
Q

What happens after chromatolysis in neuron recovery?

A

After chromatolysis, macrophages clear away debris, RNA and protein production increases, and Schwann cells multiply, forming a regeneration tube to guide new axon growth.

221
Q

What happens if the gap at the injury site is too large in PNS regeneration?

A

If the gap is too large or becomes filled with collagen fibers, new axons cannot grow, preventing full recovery.

222
Q

How fast do regenerating axons grow in the PNS?

A

Regenerating axons grow at about 1.5 mm per day across the damaged area and into the distal regeneration tubes, helping to restore some functions.

223
Q

What role do Schwann cells play in axon regeneration in the PNS?

A

Schwann cells multiply and form a regeneration tube, guiding the new axon across the damaged area and eventually forming a new myelin sheath.