Chapter 11 Basic Principles of Pharmacology Flashcards
Who is recognized as the Father of pharmacology?
Claudius Galen
What did Claudius Galen believe was the reason for illness?
It was the result of a imbalance of blood, phlegm, black bile, and yellow bile.
Father of medicine?
Hippocrates
A book that contains a list of medical substances with their formulas, uses, and methods of preparation?
Formulary
A book describing drugs, chemicals, and medicinal preparations in a country or specific geographical area?
Pharmacopeia
Any substance (other then food or device) intended for use in the diagnosis, cure, relief, treatment, or prevention of disease, or to affect the structure , or function of the human body or animals?
Drug
The study of drugs and their effects and actions on the host?
Pharmacology
What early drug was used to treat vomiting and nausea? (base for Antropine)
Belladonna
Spanish emperor Frederick II declared pharmacy a separate entity from medicine in what year?
It was not widely accepted as such until what century?
1240
16Th century
Medicines developed for the diagnosis and/or treatment of rare diseases or conditions?
Orphan drugs
Name some Diseases that may need orphan drugs
Sickle cell anemia. Lou Gehrig's disease Cystic fibrosis. Non-Hodgkin Lymphoma Hemophilia. Muscular dystrophy. Tourette's syndrome.
Name that is the precise description of a chemical composition and molecular structure?
Chemical name
The name listed in the Pharmacopoeia
Official name
Name proposed by the first manufacturer when it was submitted for approval from the FDA. (The U.S. Adopted Names Council actually assigns it)
Generic name AKA non-proprietary name
Brand name or proprietary name given the chemical compound by the company that makes it.
Trade name.
The companies drug patent is good for how long
20 years
Can the drug original drug name ever be used by another drug company after the patent has expired.
No
Large group plant based substances that contagion nitrogen and are found in nature.
Alkaloids
Common suffix for alkaloids
-ine
A compound that yields a sugar and one or more other products when it’s parts are separated.
Glycoside
Common early glycoside that comes from the Purple Foxglove plant.
Digitalis
Plant residue used for medicinal and recreational purposes.
(Common example)
Gum
Opium gum
Extracts from flowers, leaves, stems, roots, seeds, and bark.
(Common example)
Oil
Wintergreen oil
Drugs chemically derived in a lab and have no impurities?
Common example
Synthetic drugs
Insulin
Before 1980 what very common drug came from pigs and cows.
Insulin
What main system is used for drug classification?
What year was it first published?
The Anatomical Therapeutic Chemical Classification System
1976
What are the three main areas of drug classifications?
- Body system area
- Mechanism of action area
- Class of agent area
The body system area is also called
The drug physiological classification
The mechanism of action area is also called
The therapeutic classification
The class of agent area is also called the
Chemical classification
A reference that has over 4000 pages of drug info indexed by generic name official name chemical name etc and is updated every year.
Physicians desk reference.
This reference provides health care professionals with information about uses for drugs included in the labeling approved by the FDA and those that are not (OFF LABEL USES).
American Hospital Formulary Service
Before what year was their no legal control of pharmaceutical substances.
1906
The first Act the standardized the name, strength, quality, quantity, and purity of the drugs in the beginning if the twentieth century. It was eventually replaced by what Law
The Pure Food and Drug Act
The Federal Food, Drug Act of 1938
What act established the word “narcotic”
The Harrison Narcotics Act of 1914
The Harrison Act of 1914 was eventually replaced by what law in 1970
The Controlled Substance Act of 1970
What Act required everyone to have a prescription for certain drugs?
The Durham-Humphrey Amendments of 1928
What Act was the FIRST legislation that dealt with drug safety specifically due to a major tragedy that killed 107 people (mainly children)
The Federal Food, Drug, and Cosmetic Act of 1938.
The Comprehensive Drug Abuse Prevention and Control Act of 1970 does what
It is the legal basis by which the manufacture, importation, possession, and distribution of certain drugs are regulated by the US and sets up five schedules (classifications) of abuse potential and potential for addiction.
The FDA is part of what larger government agency
US Department of Health and Human Services
What agency enforces controlled substances laws and monitors the need for changing schedules of abused drugs.
DEA
The test of a substance to find out its components (amount and purity)?
Assay
What is the name if the test that takes into account the effect it has on a organism and compares it to the result with some agreed standard.
Bioassay
What reference is the official public standards-setting authority for prescription and over the counter medicines.
Pharmacopeia
Schedule I of Controlled Substances Accepted use in US. Y/N Abuse potential? Potential for addiction? Examples:
No
High
May lead to severe dependence
Heroin peyote marijuana LSD
Schedule II of Controlled Substances Accepted use in US. Y/N Abuse potential? Potential for addiction? Examples:
Yes High May lead to severe physical and psych dependence Morphine codeine oxycodone methadone pentobarbital cocaine opium
Schedule III of Controlled Substances Accepted use in US. Y/N Abuse potential? Potential for addiction? Examples:
Yes
Less abuse potential then I and II
Moderate to low physical or high psych dependence
Anabolic steroids hydro condone Vicodin Tylenol 3
Schedule IV of Controlled Substances Accepted use in US. Y/N Abuse potential? Potential for addiction? Examples:
Yes Lower abuse potential compared with III Limited physical and psych dependence Benzodiazepines lorazepam anti depressants Anti psychosis phenobarbital
Schedule V of Controlled Substances Accepted use in US. Y/N Abuse potential? Potential for addiction? Examples:
Yes
Limited physical and psych dependence
Cough suppressants with small amounts of codeine or opioids Lomotil Phrenergan
Studies on tissue models are called
In vivo
Studies on animals are called
In vitro
The FDA approval process for an Investigational drug has how many phases.
4 official phases with a preclinical that is not counted in the beginning.
Which investigational phase is closely monitored by the FDA. First time on a human. 20 to 80 people.
Phase 1
Which investigational phase is closely monitored by the FDA and is usually one a couple hundred people. Preliminary data is analyzed for effectiveness on a specific disease and side effects.
Phase II
Which investigational phase has expanded controlled and uncontrolled trials. Involves hundreds to several thousand people. Info on thy drugs effectiveness and safety is analyzed. Data on its predictability is gathered. If everything is good the manufacturer officially files a New Drug Application with the FDA.
Phase III
Which investigational phase has post marketing surveillance. Drug is released for general use. Not closely regulated by the FDA.
Phase IV
The Peripheral Nervous system consists of 2 subdivisions.
The somatic and autonomic subdivisions.
The Somatic Nervous system does what
Controls movement of voluntary muscles
The Autonomic Nervous System does what
Regulates many involuntary functions.
The Autonomic Nervous System has how many divisions and name
Two
- The sympathetic (adrenergic) system
- The parasympathetic ( cholinergic) system.
Motor pathways of the somatic nervous system use how many neurons to conduct information from the CNS to the muscle innervated by the nerve.
1
Motor pathways of the ANS use how many neurons send information from the CNS to the Effector.
2
A muscle, gland, or organ on which the ANS exerts an effect.
Effector.
Anatomically. Where does the sympathetic division of the ANS originate and extend to on the spinal column.
T1 to L2.
The parasympathetic division is composed of what cranial nerves and spinal nerves that exit the sacrum.
Cranial nerves III, VII, IX, and X.
S2 to S4
Examples if a sympathetic response.
^HR BP contraction conduction cardiac output
Bronchodilation. Shunts blood to skeletal muscles
^glucose. Pupils dilation. ^Sweat
Example of a parasympathetic response
Lower HR contractility conduction and cardiac output. Decreased RR. Bronchial constriction. Pupils constrict. Increased GI secretions
Empty bladder and bowel.
Each nerve impulse generates an action potential and chemical charge of either a neurotransmitter or ________________.
Neuropeptide
Simply, a ganglion is nothing but a
Junction between the pre ganglionic and post ganglionic nerves
The autonomic ganglion is where which two major areas meet.
The CNS and peripheral nervous system
What is the official name of the junction (ganglia) between the two neurons.
Synaptic junction
A chemical molecule that travels to the other side of the synaptic junction is called a
Neurotransmitter.
A neurotransmitter reaches the other side of the synaptic junction and interacts with a ________ in order to cause another nerve impulse or physiological action on the target organ.
Receptor
Parasympathetic stimulation often involves a response from how many organs.
1
Sympathetic preganglionic neurons are usually _______ in length and postganglionic are usually _________ in length and this explains why 1 sympathetic stimuli are so widespread as compared to Parasympathetic stimuli.
Sympathetic
Pre short.
Post long.
Two main categories of neurotransmitters.
Cholinergic and adrenergic.
In general, the adrenergic (sympathetic) neurotransmitter is
Norepinephrine
In general, the cholinergic (parasympathetic) neurotransmitter is
Acetylcholine.
The sympathetic and parasympathetic PRE ganglion neurotransmitter is always
Acetylcholine
What are the two exceptions in the sympathetic division that has acetylcholine as the main neuro transmitter.
The post ganglionic neurons that act on sweat glands and the post ganglionic neurons that act on the blood vessels of the skeletal system.
Post ganglionic fibers in the sympathetic system that release norepinephrine are called _________ fibers. And the fibers in the parasympathetic system that release acetylcholine are called _________ fibers
Adrenergic
Cholinergic
Termination if the synaptic transmission ends when the synaptic cleft is ________ of all neurotransmitters.
Cleared
What are the two main cholinergic receptors found the parasympathetic division of the CNS
- Nicotinic
2. Muscarinic
Three areas that the nicotine receptors are located
Skeletal muscle
The cells of the Adrenal medulla
The cell bodies of all post ganglionic neurons of the para sympathetic and sympathetic divisions of the ANS.
Where are muscarinic receptors located.
Located on the smooth muscle.
Acetylcholine binds to the nicotinic receptors in _________ response.
Excitatory response