Chapter 10 - Muscoloskeletal System Flashcards
What is baclofen?
centrally acting muscle relaxant
What is the MOA of NSAIDs?
Inhibition of cyclo-oxegenase enzymes - result in inhibition of prostaglandin synthesis.
Selectivity for COX enzymes vary, Those more selective for COX2 are associated with less GI intolerance
Which NSAID is associated with the least side-effects?
Ibuprofen
What is tiaprofenic acid?
NSAID
What drug class does indometacin belong to?
NSAID
What drug class does mefenamic acid belong to?
NSAID
What side-effect has been reported with mefenamic acid, which would require discontinuation?
Diarrhoea and haemolytic anaemia
What class of drug does meloxicam belong to?
NSAID
Which NSAIDs have long duration of action which means it can be administered as a OD regimen?
Piroxicam
Tenoxicam
Which NSAID is associated with more GI side-effects and associated with more frequent skin reactions?
Piroxicam
Which NSAID is licensed for the treatment of migraines?
Tolfenamic acid
Parecoxib - selective COX2 inhibitor or non-selective COX inhibitor?
selective COX 2 inhibitor
What are your selective COX2 inhibitors?
Parecoxib
Celecoxib
etoricoxib
Which NSAIDs are licensed for use for the relief of dental/orofacial pain and are able to be prescribed by dentists according to the dental formulary?
Ibuprofen and diclofenac
High doses of which 2 NSAIDs have been associated with an increased risk of thrombotic events?
Diclofenac (150mg daily) and ibuprofen (2.4g daily)
Which 3 NSAIDs are associated with the highest risk of serious upper GI side effects?
Piroxicam
Ketoprofen
ketorolac
Which NSAID has been shown to be least associated with serious upper GI side-effects?
Ibuprofen
Why should NSAIDs be avoided or are cautioned in people with asthma?
Risk of bronchospasm with NSAIDs - may therefore exacerbate or worsen asthma
