chapter 10 Flashcards
Drug
Any substance other than food affecting our bodies or minds, including alcohol, tobacco, and caffeine
Substance intoxication
Cluster of changes in behavior, emotion, or thought caused by substances (DSM-5)
Substance use disorders
Maladaptive behavior patterns and reactions caused by repeated substance use
Substance Use and Addictive Disorders checklist
• Individual displays a maladaptive pattern of substance use
leading to significant impairment or distress
• Presence of at least 2 of the following symptoms within a 1- year period
• Substance is often taken in larger amounts or over a longer period than intended
• Unsuccessful efforts or persistent desire to reduce or control substance use
• Much time spent trying to obtain, use, or recover from the effects of substance use
• Failure to fulfill major role obligations at work, school, or home as a result of repeated substance use
• Continued use of substance despite persistent social or interpersonal problems caused by it
• Cessation or reduction of important social, occupational, or recreational activities because of substance use
• Continuing to use substance in situations in which use poses physical risks
• Continuing to use substance despite awareness that it is causing or worsening a physical or psychological problem
• Craving for substance
• Toleranceeffects
• Withdrawal reactions
Tolerance
Need for increasing doses of substances to produce desired effect
Withdrawal
Unpleasant and sometimes dangerous symptoms occurring with drug stopping or cutting back
Depressants-functions and mostly widely used depressants
- Slow the activity of the central nervous system (CNS)
- Reduce tension and inhibitions
- May interfere with judgment, motor activity, and concentration
- Most widely used depressants • Alcohol
- Sedative-hypnotic drugs • Opioids
-increase GABA
• Alcohol (depressants) effect determined by level of impairment tied to effects subside after \_\_\_\_\_activy of GABA Gender affects
- Extent of the effect of ethyl alcohol is determined by its concentration (proportion) in the blood; intoxication = 0.09 percent
- Level of impairment is closely tied to the concentration of ethyl alcohol in the blood
- Effects of alcohol subside only after alcohol is metabolized by the liver
- Alcohol increases the activity of the neurotransmitter GABA at key sites in the brain
- Gender affects blood alcohol concentration
• What are the personal and social impacts of alcoholism?
plays a role in
Korsakoff’s
- Alcoholism destroys families, social relationships, and careers
- Plays a role in suicides, homicides, assaults, rapes, and accidents
- Long-term excessive drinking can seriously damage physical health and cause major nutritional problems (Korsakoff’s syndrome)
- The 30 million children of alcoholics are likely to experience a wide range of social and psychological struggles, including risk from fetal alcohol syndrome (FAS)-born with abnormalities and miscarriage
• Sedative-hypnotic (anxiolytic) drugs (depressants)
_____GABA
- Produce feelings of relaxation and drowsiness
- Low doses = calming or sedative effect
- High doses = sleep inducers or hypnotics
- Barbiturates
- Widely prescribed for the first half of the twentieth century
- Benzodiazepines
- Safer and less likely to lead to intoxication, tolerance effects, and withdrawal reactions
- Increase GABA activity
• Opioids (depressants) different types collectively known as each drug has diff how are they used? cause CNS\_\_\_\_\_\_ drugs attach to
• Include natural (opium, heroin, morphine, codeine) and
synthetic (methadone) compounds • Known collectively as “narcotics”
• By1917, opium-derived drugs were deemed addictive and illegal
• Each drug has a different strength, speed of action, and tolerance level
• Most are smoked, inhaled, snorted, injected (skin-pop or mainline), or swallowed
• Cause CNS depression; drugs attach to endorphin-related brain receptors
Opioid use disorder: an example • Heroin
- After just a few weeks, users may become caught in a pattern of abuse (and often dependence)
- Tolerance for the drug quickly builds and withdrawal occurs when drug ingestion stops
- Early withdrawal symptoms include anxiety and restlessness; later symptoms include twitching, aches, fever, vomiting, diarrhea, and weight loss from dehydration
- Increased doses are required to avoid withdrawal
pattern of abuse-dependence->tolerance->withdrawal- anxiety vominting weight losss->increased doses to avoid withdrawal
• Opioid use disorder
- Affects 2.6 million people in the United States within a given year
- 80 percent are addicted to pain relievers; 20 percent are addicted to heroin
- Mortality rate is 63 percent higher than in a non- addicted person when untreated
Stimulants function and common ones
- Stimulants increase the activity of the central nervous system (CNS)
- Cause increases in blood pressure, heart rate, and alertness
- Cause rapid behavior and thinking
- Most common stimulants
- Cocaine
- Amphetamines
- Caffeine
-increase dopamine
• Cocaine (stimulant)
produces
______the supply of ______
how is it used?
- Most powerful known natural stimulant
- Produces a euphoric rush of well-being
- Increases the supply of dopamine at key neurons throughout the brain as well as norepinephrine and serotonin levels
- Can be snorted, injected, or smoked
- Tried by 39 million people; currently used by 1.9 million people
• Effects of high doses of cocaine -cocain intoxication cocain induced psychotic disorder crashing -more powerful cheaper forms led to
- Cocaine intoxication-poor muscle coordination, bad judgement, anger
- Cocaine-induced psychotic disorder-hallucinations, confusion
- Depression-like letdown (crashing)-headaches, dizziness
- More powerful, cheaper forms have been available since 1984-increase use
- Freebasing -pure cocaine separated from processed cocaine
- Crack-freebase crystalline balls