Chapter 1: Changes with Aging

Question 1

The major impact of the physiological changes that occur with aging is:

Answer 1

All of the above
Reduced physiological reserve
Reduced homeostatic mechanisms
Impaired immunological response

Question 2

The strongest evidence regarding normal physiological aging is available through

Answer 2

Longitudinal studies

Question 3

All of the following statements are true about laboratory values in older adults except

Answer 3

Abnormal findings are often due to physiological aging

Question 4

Biochemical individuality is best described as

Answer 4

Each individual’s variation is often much smaller than that of a larger group

Question 5

Polypharmacy is best described as taking

Answer 5

Even a single medication if there is not a clear indication for its use

Question 6

Pharmacokinetic changes with aging is reflective of

Answer 6

What the body does to the drug

Question 7

All the following statements are false about drug absorption except

Answer 7

Underlying chronic disease has little impact on drug absorption

Question 8

All of the following statements are true about drug distribution in the elderly except

Answer 8

Drugs distributed in water have lower concentration

Question 9

Men have faster and more efficient biotransformation of drugs and this is thought to be due to

Answer 9

Testosterone

Question 10

The cytochrome p system involves enzymes that are generally

Answer 10

Inhibited or induced by drugs

Question 11

A statement not shown to be true about pharmacodynamics changes with aging is

Answer 11

Decreased sensitivity to oral anticoagulants

Question 12

Atypical presentation of disease in the elderly is reflected by all the following except

Answer 12

Myocardial infarction with chest pain and diaphoresis

Question 13

Functional abilities are best assessed by

Answer 13

Observed assessment of function